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Design strategies, advances and future perspectives of colon-targeted delivery systems for the treatment of inflammatory bowel disease
Publication Year: 2024 Source: Asian J Pharm Sci PMID: 39246510 DOI: 10.1016/j.ajps.2024.100943
Inflammatory bowel diseases (IBD) significantly contribute to high mortality globally and negatively affect patients' qualifications of life. The gastrointestinal tract has unique anatomical characteristics and physiological environment limitations. Moreover, certain natural or synthetic anti-inflammatory drugs are associated with poor targeting, low drug accumulation at the lesion site, and other side …
Enhanced anti-inflammatory activity of chlorogenic acid via folic acid-TPGS-modified liposomes encapsulation: characterization and In vivo evaluation on colitis mice
Publication Year: 2024 Source: Front Pharmacol PMID: 39246657
No Abstract
β-arrestin1 protects intestinal tight junction through promoting mitofusin 2 transcription to drive parkin-dependent mitophagy in colitis
Publication Year: 2024 Source: Gastroenterol Rep (Oxf) PMID: 39246845 DOI: 10.1093/gastro/goae084
BACKGROUND: Intestinal barrier defect is an essential inflammatory bowel disease (IBD) pathogenesis. Mitochondrial dysfunction results in energy deficiency and oxidative stress, which contribute to the pathogenesis of IBD. beta-arrestin1 (ARRB1) is a negative regulator that promotes G protein-coupled receptors desensitization, endocytosis, and degradation. However, its role in maintaining the intestinal …
Laparoscopic Management of an Early Postoperative Pelvic Abscess Caused by Prevotella bivia Following a Deep Infiltrating Endometriosis Surgery
Publication Year: 2024 Source: Cureus PMID: 39246919
No Abstract
An Intimate Relationship Lies Between the Appendix and the Colon: A Case Report of Colitis Cystica Profunda Post-Laparoscopic Appendectomy
Publication Year: 2024 Source: Eur J Case Rep Intern Med PMID: 39247242
No Abstract
ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
Publication Year: 2024 Source: Open Med (Wars) PMID: 39247444 DOI: 10.1515/med-2024-0993
BACKGROUND: The pathogenesis of inflammatory bowel disease (IBD) is closely associated with the dysfunction of the intestinal epithelial barrier, leading to increased bacterial translocation, leukocyte infiltration, and mucosal injury, which may act as a pivotal or incipient event in the pathophysiology of the disorder. The primary objective of this study …
The PI3K/Akt-Nrf2 Signaling Pathway and Mitophagy Synergistically Mediate Hydroxytyrosol to Alleviate Intestinal Oxidative Damage
Publication Year: 2024 Source: Int J Biol Sci PMID: 39247828 DOI: 10.7150/ijbs.97263
Oxidative stress is a major pathogenic factor in many intestinal diseases, such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). The Nrf2 signaling pathway and mitophagy can reduce reactive oxygen species (ROS) and alleviate oxidative stress, but their relationship is unclear. Hydroxytyrosol (HT), a polyphenolic compound abundant in olive …
Protective Effect of Rosavin Against Intestinal Epithelial Injury in Colitis Mice and Intestinal Organoids
Publication Year: 2024 Source: J Inflamm Res PMID: 39247835 DOI: 10.2147/JIR.S474368
INTRODUCTION: Rhodiola species have been utilized as functional foods in Asia and Europe for promoting health. Research has demonstrated that Rhodiola has the potential to alleviate inflammatory bowel disease (IBD) in animal models. However, the specific active components and the underlying mechanism for ameliorating intestinal damage remain unclear. This study …
A novel computed tomography enterography radiomics combining intestinal and creeping fat features could predict surgery risk in patients with Crohn's disease
Publication Year: 2024 Source: Eur J Gastroenterol Hepatol PMID: 39248087
No Abstract
The association between erythema nodosum and pyoderma gangrenosum and pediatric inflammatory bowel disease
Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 39248246 DOI: 10.1002/jpn3.12370
OBJECTIVES: The objectives of this study is to estimate rates and identify factors associated with erythema nodosum (EN) and pyoderma gangrenosum (PG) in pediatric patients with inflammatory bowel disease (IBD). METHODS: This cohort study examined longitudinal visits of patients aged </= 21 years from the ImproveCareNow (ICN) registry. We evaluated …
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