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Impact of age at diagnosis on college adjustment in students with inflammatory bowel disease
Publication Year: 2025 Source: JPGN Rep PMID: 40386316 DOI: 10.1002/jpr3.12162
OBJECTIVES: Little is known about the experience of college students with inflammatory bowel disease (IBD) and the factors associated with transition readiness, academic adjustment, and alternatively, those associated with academic hardship and attrition. METHODS: Survey-based cross-sectional studies, including those addressing disease-specific quality of life (Short Inflammatory Bowel Disease Questionnaire), IBD …
Inflammatory bowel disease and hereditary hemochromatosis: A case series
Publication Year: 2025 Source: JPGN Rep PMID: 40386318 DOI: 10.1002/jpr3.12167
We report a case series of three pediatric patients with inflammatory bowel disease (IBD) and variants in HFE which causes hereditary hemochromatosis (HH) type 1. Mice models suggest that these patients may be at increased risk for colitis and colon cancer. We detail the clinical course of these patients regarding …
A case of Crohn's disease in a patient with megacystis microcolon intestinal hypoperistalsis syndrome
Publication Year: 2025 Source: JPGN Rep PMID: 40386332
Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a rare congenital condition resulting in symptoms of bowel and bladder pseudo-obstruction. It carries severe morbidity and mortality; a minority of patients survive to adulthood. Recurrent bowel surgeries, small intestinal bacterial overgrowth, and slowed intestinal transit in MMIHS could serve as potential risk …
National perspectives of barriers by insurance and pharmacy benefit managers in pediatric inflammatory bowel disease
Publication Year: 2025 Source: JPGN Rep PMID: 40386337 DOI: 10.1002/jpr3.70004
OBJECTIVES: Early biologic initiation, dose optimization, and therapy modification based on disease phenotype are key to improving outcomes in pediatric inflammatory bowel disease (IBD). Enacting optimized therapy is often impeded by the lack of United States Food and Drug Administration (FDA) approval for pediatric use of newer advanced therapies or …
Self-assessment with pediatric inflammatory bowel disease endoscopy scoring tools: A quality improvement pilot study
Publication Year: 2025 Source: JPGN Rep PMID: 40386340 DOI: 10.1002/jpr3.70002
Endoscopy is a fundamental component pediatric gastroenterology (GI), with one of its primary applications being the evaluation and management of patients with inflammatory bowel disease (IBD). However, there is variation in education and experience of gastroenterologists with pediatric IBD endoscopy, which can affect the quality of patient care. This quality …
Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitis
Publication Year: 2025 Source: Res Sq PMID: 40386410
In the progression from Inflammatory Bowel Disease to associated cancer, the clonal mutational landscape shifts from selection of mutations in inflammatory genes to selection of cancer-driver mutations(1-4). How prevalence and expansion of either type of mutated clones could be impacted by the cellular environment in which they arise, and how …
IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases
Publication Year: 2025 Source: Res Sq PMID: 40386420 DOI: 10.21203/rs.3.rs-6443303/v1
Multi-omic and multimodal datasets with detailed clinical annotations offer significant potential to advance our understanding of inflammatory bowel diseases (IBD), refine diagnostics, and enable personalized therapeutic strategies. In this multi-cohort study, we performed an extensive multi-omic and multimodal analysis of 1,002 clinically annotated patients with IBD and non-IBD controls, incorporating …
Lacticaseibacillus casei 393 modulates KRAS and APC expression and cytokine levels in colitis-associated colon cancer
Publication Year: 2025 Source: J Gastrointest Oncol PMID: 40386603
BACKGROUND: Colitis-associated colon cancer (CAC) is a specific subset of colorectal cancer (CRC) affecting patients with inflammatory bowel diseases (IBDs). Chronic colon inflammation orchestrates immune surveillance or escape and may drive neoplastic initiation and progression. Lacticaseibacillus casei 393 (L. casei 393) is a lactic acid microorganism that, beyond its nutritional …
Bacillus velezensis inhibits azoxymethane/dextran sulphate sodium induced colitis associated colorectal cancer via the small molecule HeLM
Publication Year: 2025 Source: J Gastrointest Oncol PMID: 40386616 DOI: 10.21037/jgo-24-610
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory condition of the colon. There is a direct correlation between the severity and chronicity of colitis and subsequent risk of colitis associated colorectal cancer (CAC). We have recently shown that a strain of Bacillus velezensis (EHv5) can ameliorate colonic inflammation in the …
Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that bacterial uptake, rather than global dysbiosis, is the initiating factor
Publication Year: 2025 Source: Immunol Cell Biol PMID: 40386941
Crohn's disease is a chronic, transmural inflammatory disease of the human gut. Changes in the fecal microbial composition and dysbiosis are consistent features in studies of Crohn's disease patients, but whether dysbiosis is a cause or consequence of inflammation remains unresolved. Genetic susceptibility plays a role in the development of …
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