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Commensal resilience: ancient ecological lessons for the modern microbiota
Publication Year: 2025 Source: Infect Immun PMID: 40387449
The gut microbiota constitutes a complex ecosystem essential for host health, offering metabolic support, modulating the immune system, and protecting against pathogens. However, this community faces constant destabilizing challenges, including dietary changes, antibiotics, and enteric infection. Prolonged microbiota imbalance or dysbiosis can exacerbate intestinal disease states, including inflammatory bowel disease …
Colo-Protective Effects of Pentoxifylline Alone or in Combination With Mesalamine in Colitis Through Sphingosine Kinase 1/Sphingosine 1 Phosphate, and Zonula Occuldin 1 Pathways: New Molecular Approach
Publication Year: 2025 Source: Pharmacol Res Perspect PMID: 40387460
No Abstract
Gut-heart axis: cardiac remodeling and heart failure in the context of inflammatory bowel disease and dysbiosis
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 40387516 DOI: 10.1152/ajpgi.00016.2025
Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are debilitating and complex chronic gastrointestinal disorders that affect not only the gut but also extraintestinal organs, including the heart. The gut-heart cross talk has garnered increasing attention in recent years; however, the molecular mechanisms underlying this complex interplay remain …
Correction to: Autoimmune Pancreatitis in Patients with Inflammatory Bowel Disease: A Real-World Multicentre Collaborative ECCO CONFER Study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40387533
No Abstract
How "Sure" Are We About Precision Medicine in IBD?
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40387714 DOI: 10.1002/ueg2.70048
No Abstract
Autonomic nervous system abnormalities in children with inflammatory bowel disease and irritable bowel syndrome: a comparative study
Publication Year: 2025 Source: Clin Auton Res PMID: 40387976 DOI: 10.1007/s10286-025-01134-8
OBJECTIVES: This study aimed to investigate the subjective and objective autonomic nervous system (ANS) abnormalities in children with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) compared with healthy children (HC). METHODS: In total, 69 children were enrolled: 23 in the IBD, 28 in the IBS, and 18 HC …
Correction: Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial
Publication Year: 2025 Source: Dig Dis Sci PMID: 40387989
No Abstract
Causal Relationship Between Polycystic Ovary Syndrome and Autoimmune Diseases: A Two-Sample Mendelian Randomization Study
Publication Year: 2025 Source: Am J Reprod Immunol PMID: 40388209 DOI: 10.1111/aji.70083
PROBLEM: Polycystic ovary syndrome (PCOS) is known to be associated with immune response dysregulation, resembling autoimmune diseases. However, the causal relationship between PCOS and autoimmune diseases remains unclear. METHODS: A two-sample bidirectional Mendelian randomization (MR) analysis was conducted using publicly available genome-wide association study (GWAS) data. The primary causal effects …
Soluble Dietary Fiber from Fermentation of Tea Residues by Eurotium cristatum and the Effects on DSS-Induced Ulcerative Colitis
Publication Year: 2025 Source: J Agric Food Chem PMID: 40388219
Tea residues are rich in dietary fiber, most of which are insoluble dietary fiber (IDF). However, soluble dietary fiber (SDF) is reported to show a better health-promoting effect. In this paper, the Eurotium cristatum (E. cristatum) fermentation method was employed to prepare SDF from tea residues. The results showed that …
Exploring the dual role of Mangifera indica L. in regulating immune response and pain persistence in inflammatory bowel disease
Publication Year: 2025 Source: Pharmacol Res PMID: 40389041 DOI: 10.1016/j.phrs.2025.107773
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is characterized by chronic intestinal inflammation and immune dysregulation, driven mainly by Th1 and Th17 cells and sustained by pro-inflammatory cyto-chemokines. This inflammatory milieu is associated with visceral pain, a key symptom affecting patient quality of life. Addressing both gut …
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