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Two Birds with One Stone: Empowering Probiotic with Nanoenzyme for the Treatment of Inflammatory and Anemia through Oral Administration
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 40395049
In the context of ulcerative colitis (UC), iron deficiency anemia (IDA) is often presented as a prevalent systemic manifestation. However, there is an absence of an effective strategy for the specific case of UC with IDA. Herein, mendelian randomization (MR) analysis is applied to confirm the causal association between UC …
Protective effects of Arbutus unedo extract on acetic acid-induced colitis in rats: histological, biochemical, and antioxidant assessments
Publication Year: 2025 Source: J Sci Food Agric PMID: 40395169
BACKGROUND: This study aimed to analyze the advantageous effects of the decoction aqueous extract of Arbutus unedo fruits (AUFDE) against ulcerative colitis (UC) caused by acetic acid (AA) in rats, along with the processes involved in this protective effect. Adult male Wistar rats were divided into six groups: control (H(2)O), …
Acquired Immunodeficiency Syndrome With Suspected Early Inflammatory Bowel Disease Diagnosed Following Gastrointestinal Symptoms
Publication Year: 2025 Source: Cureus PMID: 40395250 DOI: 10.7759/cureus.82600
A 35-year-old man who has sex with men (MSM) visited another hospital for soft stools, lower abdominal pain, and nausea. Gastroscopy (GS) and colonoscopy (CS) revealed esophageal candidiasis and rectal ulcers, for which fluconazole (FLCZ) and metronidazole (MNZ) were prescribed. Four days later, the patient was referred to our hospital. …
First Description of Simultaneous Sweet Syndrome and Tracheal Stenosis as Extraintestinal Manifestations in a Patient With Highly Active Ulcerative Colitis
Publication Year: 2025 Source: ACG Case Rep J PMID: 40395659 DOI: 10.14309/crj.0000000000001712
Sweet syndrome and tracheal stenosis are very rare extraintestinal manifestations of inflammatory bowel diseases. In this study, we present a patient with ulcerative colitis, who developed Sweet syndrome in combination with an acute tracheal stenosis causing a life-threatening situation requiring admission to the intensive care unit. The patient had an …
Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis
Publication Year: 2025 Source: Front Pharmacol PMID: 40395731 DOI: 10.3389/fphar.2025.1539469
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic, potentially carcinogenic condition with limited treatment options. Rutin may represent a novel approach to treating IBD. Our aim is to conduct a systematic review of rutin, summarize its preclinical effects, demonstrate its efficacy, and provide guidance for future research. METHODS: To systematically …
Effect of Tissue Eosinophilia on the Disease Outcome of Pediatric With Inflammatory Bowel Disease (IBD)
Publication Year: 2025 Source: JGH Open PMID: 40395749 DOI: 10.1002/jgh3.70187
BACKGROUND: It seems that the presence of tissue eosinophils in IBD patients can provide more information to predict the prognosis and outcome of the disease, especially in children. However, there is very limited evidence in this regard. Here, we designed a retrospective study to investigate the effect of tissue eosinophils …
The alleviating effects and mechanisms of Enterococcus faecium Kimate-X and Lactobacillus plantarum Kimate-F combination on canine inflammatory bowel disease
Publication Year: 2025 Source: Front Vet Sci PMID: 40395807 DOI: 10.3389/fvets.2025.1534665
INTRODUCTION: Canine inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation and dysbiosis. Conventional treatments often result in adverse effects and contribute to antibiotic resistance, highlighting the need for safe, effective alternatives. Probiotics have gained attention for their potential in modulating gut microbiota and immune responses. This study investigates …
HS-GC-MS Method for the Diagnosis of IBD Dynamics in a Model of DSS-Induced Colitis
Publication Year: 2025 Source: Bio Protoc PMID: 40395844 DOI: 10.21769/BioProtoc.5246
Inflammatory bowel disease (IBD) is highly prevalent globally and, in the majority of cases, remains asymptomatic during its initial stages. The gastrointestinal microbiota secretes volatile organic compounds (VOCs), and their composition alters in IBD. The examination of VOCs could prove beneficial in complementing diagnostic techniques to facilitate the early identification …
BECLIN-1 is essential for the maintenance of gastrointestinal epithelial integrity by regulating endocytic trafficking, F-actin organization, and lysosomal function
Publication Year: 2025 Source: Autophagy Rep PMID: 40395982 DOI: 10.1080/27694127.2025.2484494
Disrupted intestinal homeostasis and barrier function contribute to the development of diseases such as inflammatory bowel disease. BECLIN-1, a core component of two class III phosphatidylinositol 3 kinase complexes, has a dual role in autophagy and endocytic trafficking. Emerging evidence suggests that its endocytic trafficking function is essential for intestinal …
Identifying the e-health prevalence and influence pattern: A cross-sectional study
Publication Year: 2025 Source: J Family Med Prim Care PMID: 40396077 DOI: 10.4103/jfmpc.jfmpc_1231_24
BACKGROUND: Internet has transformed healthcare by providing unparalleled access to medical information, resources and support. OBJECTIVE: This study explores the prevalence, reasons why people turn to the Internet for their healthcare information needs, and highlighting potential benefits, limitation of their assessments experiences. METHODS: This study was conducted amongst OPD visiting …
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