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High Ultra-Processed Food Consumption Is Associated with Clinical Exacerbation in Patients with Crohn's Disease in Remission: A Prospective Cohort Study
Publication Year: 2025 Source: Dig Dis PMID: 40393424 DOI: 10.1159/000546486
INTRODUCTION: Diet can impact the clinical course of Crohn's disease (CD). However, the importance of food processing level is uncertain. We aimed to evaluate whether ultra-processed foods (UPFs) are associated with an increased risk of relapse among patients with CD in clinical remission. METHODS: In this prospective cohort study, adult …
Oral administration of nanoemulsion of supercritical fluid extract of Angelica with quaternized chitosan alleviates ulcerative colitis in mice
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40393582
Supercritical Fluid Extract of Angelica (ASFE) shows potential for treating ulcerative colitis (UC) and colorectal cancer. This study prepared ASFE-quaternized chitosan nanoemulsion (ASFE-QCSNE) using low-energy emulsification with quaternized chitosan as the carrier. The formulation was optimized via pseudo-ternary phase diagrams combined with D-optimal mixture design. The physicochemical properties of ASFE-QCSNE …
[Intervention effect analysis of TPMT and NUDT15 genotyping on the tolerability of azathioprine or 6-mercaptopurine therapy in pediatric inflammatory bowel disease]
Publication Year: 2025 Source: Zhonghua Er Ke Za Zhi PMID: 40393756 DOI: 10.3760/cma.j.cn112140-20250415-00338
Objective: To investigate the impact of pre-treatment TPMT and NUDT15 genotyping on medication selection, tolerability and discontinuation rates of azathioprine or 6-mercaptopurine therapy in children with inflammatory bowel disease (IBD). Methods: A retrospective cohort study was conducted on 181 children with IBD who were scheduled for azathioprine or 6-mercaptopurine therapy …
Probiotics may not adhere to gut and provide benefits in inflammatory bowel disease patients based on an AOM/DSS murine model
Publication Year: 2025 Source: J Formos Med Assoc PMID: 40393834 DOI: 10.1016/j.jfma.2025.05.010
BACKGROUND: Dysbiosis, characterized by imbalanced gut microbiota, is common in patients with inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). While probiotics theoretically offer promise for IBD treatment, their actual efficacy remains uncertain, leading to non-recommendation in current guidelines. Akkermansia muciniphila (AKK) is a potential next-generation probiotic strain with …
SPH3127 (Sitokiren), a Novel Renin Inhibitor, Suppresses Colitis Development in Mouse Models of Experimental Colitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40393940
BACKGROUND: Emerging evidence suggests that the renin-angiotensin system plays an important role in the pathogenesis of inflammatory bowel disease, but few studies have directly assessed the therapeutic effect of renin inhibitors on colitis development. METHOD: Experimental colitis was induced in wild-type C57BL/6 mice and renin transgenic (RenTg) mice by 2,4,6-trinitrobenzene …
Inflammation and IL-4 regulate Parkinson's and Crohn's disease associated kinase LRRK2
Publication Year: 2025 Source: EMBO Rep PMID: 40394349
Mutations in Leucine-Rich Repeat protein Kinase 2 (LRRK2) are associated with Parkinson's disease (PD) and Crohn's disease (CD), but the regulation of LRRK2 during inflammation remains relatively unexplored. Here we describe the development of a flow cytometry-based assay to assess LRRK2 activity in individual cells and the generation of an …
Marked mucosal lipid shifts in treatment refractory inflammatory bowel disease: a lipidomic study
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40394475 DOI: 10.1186/s12876-025-03944-6
No Abstract
The signature of the small intestinal epithelial and immune cells in health and diseases
Publication Year: 2025 Source: Chin Med J (Engl) PMID: 40394804
The small intestine is essential for digestion, nutrient absorption, immune regulation, and microbial balance. Its epithelial lining, containing specialized cells like Paneth cells and tuft cells, is crucial for maintaining intestinal homeostasis. Paneth cells produce antimicrobial peptides and growth factors that support microbial regulation and intestinal stem cells, while tuft …
With guselkumab, does the dual mechanisms to inhibit IL-23, help in ulcerative colitis?
Publication Year: 2025 Source: Expert Opin Biol Ther PMID: 40394835
INTRODUCTION: Ulcerative colitis (UC) includes a dysregulated immune response. The conventional therapy includes immunosuppressants, and biologics targeting inflammatory mediators, but these are often inadequate, or subjects become unable to tolerate them. AREAS COVERED: QUASAR: the induction and maintenance components of the phase 3 trial of guselkumab, which inhibits IL-23 by …
Smart Silk-Based In Situ Sol-Gel Modulates Rectal Microenvironment for Effective Ulcerative Colitis Alleviation
Publication Year: 2025 Source: Adv Healthc Mater PMID: 40394946
Ulcerative colitis (UC) is a chronic inflammatory bowel disease, with untreated cases often progressing to colorectal cancer. Current treatments aim to induce inflammatory remission but often neglect the surrounding microenvironment, which significantly impairs mucosal healing and contributes to treatment failures. This study presents a novel silk fibroin-based fucoidan (SFU) in …
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