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Loss of proton-sensing GPR4 reduces tumor progression in mouse models of colon cancer
Publication Year: 2025 Source: Mol Oncol PMID: 40397803 DOI: 10.1002/1878-0261.70045
We aimed to understand the role of G protein-coupled receptor 4 (GPR4) in tumorigenesis. GPR4 is a pH-sensing receptor that is activated by acidic extracellular pH. GPR4 is expressed primarily in vascular endothelial cells (ECs). Intestinal tissue from patients with inflammatory bowel disease (IBD) shows increased expression of GPR4. Patients …
Multi-omics analysis reveals classic decoction alleviates ulcerative colitis by modulating tryptophan metabolism, gut microbiota homeostasis, and mitochondrial Bax/Bcl-2 pathways
Publication Year: 2025 Source: J Pharm Biomed Anal PMID: 40398245
Gegen Qinlian Decoction (GQD), a classic decoction documented in the Treatise on Febrile Diseases, is clinically used to treat ulcerative colitis (UC). However, the active components and underlying pharmacological mechanisms of GQD in UC remain inadequately explored. Herein, we identify the active components and elucidate the underlying pharmacological mechanisms of …
Fidaxomicin Reduces Collagen Expression in Intestinal Fibroblasts Via Platelet-Derived Growth Factor Receptor Beta and Glycogen Synthase Kinase-3 Beta Inhibition
Publication Year: 2025 Source: Gastroenterology PMID: 40398622
INTRODUCTION: About 30%-50% of patients with Crohn's disease (CD) eventually develop intestinal strictures, with intestinal fibrosis being a major component of them. There is currently no approved medication to treat fibrotic strictures. METHODS: 10X Genomics Visium spatial RNA sequencing and high-throughput screening were used to discover the molecular targets of …
Serum Vitamin D Levels and Long-Term Risk of Elderly-Onset Inflammatory Bowel Disease: A Large-Scale Prospective Cohort Study
Publication Year: 2025 Source: Am J Med PMID: 40398635
BACKGROUND: Vitamin D is considered as a potential immunomodulator in inflammatory bowel disease development; however, emerging evidence remains inconsistent. We aimed to investigate the prospective association between serum vitamin D level and long-term risk of elderly-onset inflammatory bowel disease in a large-scale cohort. METHODS: Participants without inflammatory bowel disease at …
Comparative outcomes of laparoscopic and open surgery in inflammatory bowel disease in pediatric and young adult patients: a systematic review and meta-analysis
Publication Year: 2025 Source: J Gastrointest Surg PMID: 40398665 DOI: 10.1016/j.gassur.2025.102085
BACKGROUND: Pediatric inflammatory bowel disease (IBD), encompassing Crohn's disease, ulcerative colitis, and indeterminate colitis, often necessitates surgical intervention in cases of severe or refractory disease. Although biologic therapies have significantly reduced the need for surgery, operative management remains essential for certain patients. The choice between laparoscopic (laparoscopy group [LG]) and …
Long-term Cardiovascular, Renal, and Safety Outcomes of Teprotumumab versus Systemic Glucocorticoids in Thyroid Eye Disease: A Target Trial Emulation
Publication Year: 2025 Source: Ophthalmology PMID: 40398692
PURPOSE: The insulin-like growth factor-1 receptor inhibitor teprotumumab is effective for thyroid eye disease (TED), but there is limited evidence on its long-term safety. We studied the long-term cardiovascular, renal, infectious, and safety outcomes of teprotumumab compared with intravenous (IV) glucocorticoids (GCs), oral GCs, and conservative treatment in patients with …
PErsistence and safety of subcutaneous infliximab 1 year after switch from intravenous route in IBD patients in REMission
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40398832 DOI: 10.1016/j.cgh.2025.04.028
BACKGROUND AND AIMS: Real-life data regarding inflammatory bowel disease (IBD) evolution after switch from intravenous infliximab (IV-IFX) to subcutaneous infliximab (SC-IFX) is necessary. The aim of this prospective multicenter cohort study was to describe the persistence, effectiveness and tolerance of SC-IFX after switch from IV-IFX. METHODS: IBD patients in steroid-free …
Gut Microbiota and Interorgan Communication among the Gut, Brain, and Beyond
Publication Year: 2025 Source: Intern Med PMID: 40399081
The intestinal tract contains the largest reservoir of lymphoid tissue in the body and it communicates with other organs through metabolites, cytokine activation, and the migration of gut immune cells. In particular, the liver interacts with the gut through the portal vein and bile ducts. Furthermore, the frequent abdominal symptoms …
Hydrogen sulfide preserves intestinal barrier repair function through sulfhydration of RPS20 in experimental colitis
Publication Year: 2025 Source: Sci Rep PMID: 40399407 DOI: 10.1038/s41598-025-02268-5
Patients with ulcerative colitis (UC) have a significantly impaired intestinal barrier. Hydrogen Sulfide (H(2)S) is a gaseous mediator that makes notable contributions in a variety of diseases, such as reducing inflammatory response in colitis. The experimental content includes the establishment of a mouse DSS-induced colitis mouse model, mouse colon epithelial …
Bidirectional mendelian randomization assessment of causality between lactate levels and multiple autoimmune diseases
Publication Year: 2025 Source: Sci Rep PMID: 40399513 DOI: 10.1038/s41598-025-02507-9
Bidirectional two-sample Mendelian randomization (MR) was performed to provide genetic evidence for the causal association between multiple sclerosis (MS), type 1 diabetes(T1D), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), Crohn's disease (CD), systemic lupus erythematosus (SLE), ulcerative colitis (UC) and lactate levels. Inverse variance weighted (IVW), weighted median estimator …
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