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Epidemiologic sequential analysis of pure red blood cell aplasia and T-cell large granular lymphocyte leukemia in Korea
Publication Year: 2025 Source: Ann Hematol PMID: 40399532
Pure red cell aplasia (PRCA) is a rare hematologic syndrome characterized by anemia with marked reticulocytopenia and, in Asia, is often accompanied by T-cell large granular lymphocyte leukemia (T-LGL). Minimal research has been done on the epidemiology and sequential events of PRCA combined with T-LGL. This study identified 2801 PRCA …
Spontaneous restoration of premature ovarian insufficiency and conception in a patient with glycogen storage disease type 1b managed with empagliflozin
Publication Year: 2025 Source: Hormones (Athens) PMID: 40399615
Glycogen storage disease type 1b (GSD-1b) is a rare genetic disorder characterized by deficiencies in glucose metabolism, leading to severe hypoglycemia, neutropenia, inflammatory bowel disease, and other metabolic abnormalities. We report the case of a 32-year-old woman with genetically confirmed GSD-1b who experienced premature ovarian failure and spontaneous restoration of …
Anti-inflammatory effects and gut microbiota modulation of synbiotic mulberry in DSS-induced colitis rats
Publication Year: 2025 Source: Mol Cell Biochem PMID: 40399636 DOI: 10.1007/s11010-025-05309-9
The global incident shows that the number of inflammatory bowel disease (IBD) cases increased by 88.30% in 2021 and significantly influenced patients' quality of life. Synbiotics are recommended as an alternative or supplement for IBD. We formulated synbiotic mulberry (SM) by mixing mulberry powder, probiotic biomass, and inulin. However, the …
Genetic Mutations and Small Bowel Ulcerating Disease: Role in Diagnosis?
Publication Year: 2025 Source: Curr Gastroenterol Rep PMID: 40399663
PURPOSE OF REVIEW: This review examines the role of genetic variations in the pathogenesis of small bowel (SB) ulcers associated with Crohn's disease (CD), NSAID enteropathy, and Cryptogenic Multifocal Ulcerous Stenosing Enteritis (CMUSE)/Chronic Non-Specific Ulcers of the Small Intestine (CNSU), aiming to address current diagnostic challenges. RECENT FINDINGS: Advances in …
Initial development and validation of a disease-specific resilience measure for inflammatory bowel disease: the RISE-IBD instrument
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40399791 DOI: 10.1186/s12876-025-03971-3
BACKGROUND: Inflammatory bowel diseases (IBDs) have a substantial effect on the well-being and quality of life of patients. While resilience may help alleviate psychological and physical burdens in individuals with IBD, there is no disease-specific measure that currently exists to accurately quantify this construct in the context of IBD. This …
Unveiling the hidden dance: SPP1 + macrophages identified in ulcerative colitis reveal crosstalk with CHI3L1 + fibroblasts
Publication Year: 2025 Source: J Transl Med PMID: 40399882
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon. The specific cause of UC is still not fully understood, but this condition is believed to arise from a combination of environmental, genetic, microbial, and immune factors. This study aimed to explore the …
The Incidence and Management of TNF-α Inhibitor Induced Paradoxical Psoriasis in Children With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Australas J Dermatol PMID: 40400050 DOI: 10.1111/ajd.14526
Paradoxical psoriasis is a well-described phenomenon following treatment with Tumour Necrosis Factor alpha (TNF-alpha) inhibitors in adult patients with Inflammatory Bowel Disease (IBD). The incidence and optimal treatment strategies are not well described in children with IBD. This subgroup of patients is disproportionately impacted by TNF-alpha inhibitor-induced psoriatic eruptions. Our …
Effects of infliximab infusion on clinical symptom scores and serum cytokines in patients with inflammatory bowel disease
Publication Year: 2025 Source: Immunopharmacol Immunotoxicol PMID: 40400059 DOI: 10.1080/08923973.2025.2504908
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder. Infliximab (INF) has shown good efficacy in IBD treatment, but its specific impact requires further exploration. This study aimed to assess the effects of intravenous INF on clinical symptom scores and serum cytokine levels in IBD patients. METHODS: A …
Serum C-Reactive Protein as a Potential Indicator for Screening Fecal Calprotectin in Patients With Moderate-to-Severe Hidradenitis Suppurativa: A Cross-Sectional Cohort Study
Publication Year: 2025 Source: Int J Dermatol PMID: 40400092 DOI: 10.1111/ijd.17868
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder frequently associated with immune-mediated comorbidities, including inflammatory bowel disease (IBD). Given the potential risk of IBD, particularly before initiating therapies such as interleukin (IL)-17 inhibitors, screening through a fecal calprotectin (FC) test may be warranted. While FC is a reliable, …
Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota
Publication Year: 2025 Source: Clin Transl Med PMID: 40400119 DOI: 10.1002/ctm2.70329
BACKGROUND: The multidimensional regulatory mechanism of the gut-brain-immune axis in the context of inflammatory bowel disease (IBD) has garnered significant attention, particularly regarding how intestinal microbiota finely regulates immune responses through immune cells and sensory neurons. MAIN BODY: Metabolites produced by intestinal microbiota influence the phenotype switching of immune cells …
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