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The fitness effects of outcrossing distance depend on parental flowering phenology in fragmented populations of a tallgrass prairie forb
Publication Year: 2025 Source: New Phytol PMID: 40400232 DOI: 10.1111/nph.70240
The phenomena of isolation-by-distance and isolation-by-time shapecontra mating patterns and population genetic processes, such as inbreeding and outbreeding depression, which influence progeny fitness. However, the effects of parental isolation in time on offspring fitness remain understudied, especially in combination with isolation-by-distance. We planted offspring from a common garden experiment involving …
β-Sitosterol Ameliorates Ulcerative Colitis Through Modulation of the AMPK/MLCK Anti-Inflammatory Pathway
Publication Year: 2025 Source: J Biochem Mol Toxicol PMID: 40400313
Ulcerative colitis (UC), a common inflammatory bowel disease, has become increasingly prevalent worldwide, posing significant health challenges. This study explored the anti-inflammatory effects of beta-sitosterol on UC and its underlying molecular mechanisms. Using a dextran sulfate sodium (DSS)-induced colitis model in male C57BL/6 mice, the therapeutic potential of beta-sitosterol at …
Effectiveness and Safety of a Second JAK Inhibitor in Ulcerative Colitis: The J2J Multicentre Study
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40400411 DOI: 10.1111/apt.70199
BACKGROUND: While three Janus kinase inhibitors (JAKi) have demonstrated efficacy in ulcerative colitis (UC), scarce data exist regarding JAKi intraclass switching. AIM: To evaluate the effectiveness and safety of a second JAK inhibitor in UC. METHODS: This was a multicentre, retrospective, observational cohort including patients with moderate to severe UC …
Per- and polyfluoroalkyl substances (PFAS): immunotoxicity at the primary sites of exposure
Publication Year: 2025 Source: Crit Rev Toxicol PMID: 40400477
Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals widely used in industrial and consumer products, leading to environmental contamination and human exposure. This review focuses on perfluoroalkyl acids, a subset of PFAS, which are primarily encountered through diet, including drinking water, and other pathways such as dust ingestion, and …
Systemic Lupus Erythematosus as a Risk Factor for Encapsulating Peritoneal Sclerosis: A Case Report
Publication Year: 2025 Source: Cureus PMID: 40400866
Encapsulating peritoneal sclerosis (EPS) refers to the insidious formation of a thick fibrous cocoon encasing the intra-abdominal organs and may lead to bowel obstruction. EPS is a known but rare complication of chronic peritoneal dialysis (PD) due to the long-term exposure of glucose degradation products and recurrent peritonitis, promoting inflammatory …
History of Previous Medication Self-Discontinuation Predicts the Current Adherence to 5-Aminosalicylates in Patients With Ulcerative Colitis
Publication Year: 2025 Source: JGH Open PMID: 40401184
AIM: Medication adherence is critical in 5-aminosalicylate therapy for patients with ulcerative colitis. Patients with a history of previous medication self-discontinuation may continue to have low adherence due to the influence of inappropriate disease awareness. This study aimed to determine the association between the history of previous medication self-discontinuation and …
Pregnant Pause? Not for IBD Care-A Single Tertiary Care Center Prospective Cohort Study Affirming IBD Management in Pregnancy
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40401215 DOI: 10.1093/crocol/otaf029
BACKGROUND: This study examined Inflammatory Bowel Disease (IBD) management and outcomes during pregnancy in a tertiary care setting, focusing on disease activity, medication use, and maternal and neonatal outcomes. METHODS: A prospective cohort study followed 287 women with IBD through 291 pregnancies from 2017 to 2023 at a single tertiary …
Patient-reported real-world experience of risankizumab on-body device (OBD) for the treatment of Crohn's disease in the UK (COMMODUS)
Publication Year: 2025 Source: Curr Med Res Opin PMID: 40401545
OBJECTIVE: To evaluate real-world patient-reported experience with subcutaneous (SC) risankizumab administered by on-body device (OBD) in patients with Crohn's disease (CD). METHODS: Uncontrolled observational cross-sectional study in five UK units between October 2023 and May 2024. Patients who had received maintenance risankizumab via SC injection of four pre-filled syringes (PFS) …
Genomic insights into novel predatory myxobacteria isolated from human feces
Publication Year: 2025 Source: Microbiol Spectr PMID: 40401933 DOI: 10.1128/spectrum.02147-24
Myxobacteria are Gram-negative, spore-forming predatory bacteria isolated from diverse environmental samples that feed on other microbes for their survival and growth. However, no reports of cultured representatives from the human gut have been published to date, although previous investigations have revealed the presence of myxobacterial operational taxonomic units (OTUs) in …
The 2024 top 10 list of endoscopy topics in medical publishing: an annual review by the American Society for Gastrointestinal Endoscopy Editorial Board
Publication Year: 2025 Source: Gastrointest Endosc PMID: 40402124
Using a systematic literature search of original articles published during 2024 in Gastrointestinal Endoscopy (GIE) and other high-impact medical and gastroenterology journals, the GIE Editorial Board of the American Society for Gastrointestinal Endoscopy compiled a list of the top 10 most significant topic areas in general and advanced GI endoscopy …
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