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Monogenic SLCO2A1 gene mutation presenting as early onset inflammatory bowel disease-A report of rare case with review of literature
Publication Year: 2025 Source: Indian J Pathol Microbiol PMID: 40405524
Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a rare, autosomal recessive disorder characterized by multiple chronic ulcerative and structuring lesions in the small intestine, primarily affecting the ileum. It often presents with symptoms of chronic blood loss and protein loss, including iron deficiency anemia and abdominal pain, similar …
Intestinal spirochetosis -A mystical entity- A tale of two pediatric cases
Publication Year: 2025 Source: Indian J Pathol Microbiol PMID: 40405559 DOI: 10.4103/ijpm.ijpm_685_24
Intestinal spirochetosis (IS) is an uncommon infection in pediatric population. It is often found in immunocompromised or homosexual adult individuals. It can mimic inflammatory bowel disease (IBD) in immunocompetent pediatric population with similar presentation of abdominal pain, rectal bleeding and bloody diarrhea. The diagnosis of IS requires careful histopathological examination …
Endoscopic Scoring in Ulcerative Colitis: Evaluating Practice Patterns and Role of Educational Interventions
Publication Year: 2025 Source: Br J Hosp Med (Lond) PMID: 40405852
Aims/Background Endoscopic scoring systems are recommended internationally for assessing disease activity, response to therapy and mucosal healing. However, their real-world application remains inconsistent. This study aimed to evaluate the impact of an educational intervention on endoscopic scoring documentation and identify factors influencing its use. Methods A retrospective observational study was …
Identification and validation of shared biomarkers and drug repurposing in psoriasis and Crohn's disease: integrating bioinformatics, machine learning, and experimental approaches
Publication Year: 2025 Source: Front Immunol PMID: 40406126
BACKGROUND: Psoriasis and Crohn's disease (CD) are chronic inflammatory diseases that involve complex immune-mediated mechanisms. Despite clinical overlap and shared genetic predispositions, the molecular pathways connecting these diseases remain incompletely understood. The present study seeks to identify shared biomarkers and therapeutic targets for psoriasis and CD. METHODS: Differentially expressed genes …
Impact of a Maternal Medicine Hub on post-partum haemorrhage in women with inherited bleeding disorders: A retrospective service evaluation
Publication Year: 2025 Source: Obstet Med PMID: 40406190 DOI: 10.1177/1753495X251338642
BACKGROUND: We investigated the impact of the Maternal Medicine Network Hub, established at our centre in 2019, on post-partum haemorrhage (PPH) management in women with inherited bleeding disorders (IBDs). METHODS: Data from 63 patients with IBDs between 2020 and 2023 were compared to a general obstetric cohort. Specific data collected …
A Rare Manifestation of Abdominal Pain in Systemic Lupus Erythematosus: A Case Report on Lupus Enterocolitis
Publication Year: 2025 Source: Cureus PMID: 40406783
Systemic lupus erythematosus (SLE) is an autoimmune disease that commonly affects the skin, kidneys, and musculoskeletal system. We present a case of lupus enterocolitis, a rare manifestation of SLE that affects the small and large bowel. The case involves a 17-year-old woman with SLE, presenting with a seven-day history of …
Elucidation of Molecular Mechanisms of Sulfated Oligoguluronic Acid on Mitigating Intestinal Inflammation and Enhancing Epithelial Barrier Function
Publication Year: 2025 Source: J Agric Food Chem PMID: 40406814
This study investigates the protective role of sulfated oligoguluronic acid (SOGA), synthesized from polyguluronic acid (PG)-derived oligoguluronic acid (OGA), against intestinal inflammation and barrier dysfunction. In vitro, SOGA significantly reduced LPS-induced proinflammatory cytokine secretion in THP-1 cells, whereas PG and OGA were ineffective. Mechanistic investigations revealed that SOGA effectively inhibited …
Inflammatory Bowel Disease in the Post-STRIDE II Era: Epidemiology and Long-Term Clinical Outcomes from a Population-Based Study
Publication Year: 2025 Source: Med Sci (Basel) PMID: 40407550 DOI: 10.3390/medsci13020055
Background/Objectives: Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC). The availability of an increasing number of new molecules approved for IBD treatment has increased our ability and aspirations to change the trajectory of the disease. The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) II consensus …
Systemic Inflammation and Disruption of the Local Microenvironment Compromise Muscle Regeneration: Critical Pathogenesis of Autoimmune-Associated Sarcopenia
Publication Year: 2025 Source: Interact J Med Res PMID: 40407708
Sarcopenia is defined by age-related reductions in muscle mass, strength, and physiological function, and it is especially prevalent among individuals with autoimmune diseases. Autoimmune disorders, characterized by immune dysregulation, cause systemic inflammation and damage to multiple tissues through unregulated immune activity. Research indicates that autoimmune diseases negatively impact skeletal muscle …
Reshaping the gut microbiota to ameliorate DSS-induced colitis using a novel synbiotic consisting of jujube powder and Faecalibacterium prausnitzii
Publication Year: 2025 Source: Food Funct PMID: 40407723
Ulcerative colitis (UC) remains challenging to existing therapeutic approaches, which may have variable efficacy, side effects, and high relapse rates. Increasing evidence indicates the critical role of the gut microbiota in UC pathogenesis, making microbiota-targeted therapies promising for treatment. Here, we propose a novel synbiotic consisting of jujube powder and …
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