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Network Meta-Analysis: Efficacy of Biological Therapies and Small Molecules as Maintenance Therapy in Ulcerative Colitis
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40407729
BACKGROUND: Numerous biologics and small molecules are licensed as maintenance therapy for ulcerative colitis (UC). Differences in the design of randomised controlled trials (RCTs) have not been considered when comparing efficacy between them. AIMS: To examine the relative efficacy of biologics and small molecules by network meta-analysis according to trial …
Risk of colectomy is decreasing among newly diagnosed Finnish ulcerative colitis patients
Publication Year: 2025 Source: J Crohns Colitis PMID: 40355369
BACKGROUND AND AIMS: The risk of colectomy in patients with ulcerative colitis (UC) has decreased since the 20th century. Our aim was to determine the colectomy risk of newly diagnosed Finnish UC patients and compare the risk of the prebiological and biological era. METHODS: We used the registry of the …
Prediction of endoscopic restenosis after endoscopic balloon dilation in patients with Crohn's disease: a machine learning approach
Publication Year: 2025 Source: Surg Endosc PMID: 40355737
BACKGROUND: Endoscopic balloon dilation (EBD) is recognized as a minimally invasive and effective procedure for managing intestinal stenosis in patients with Crohn's disease (CD). It offers an alternative to surgery and has been shown to improve the quality of life for these patients by reducing the need for more aggressive …
Surgical trend including minimally invasive surgeries for ulcerative colitis in the COSUC study: the largest multicenter cohort study in Japan
Publication Year: 2025 Source: Surg Endosc PMID: 40355738
BACKGROUND: The number of patients with ulcerative colitis (UC) is increasing rapidly in Asia. No large study has evaluated the clinical outcomes of hand-sewn ileal pouch-anal anastomosis (IPAA). This study aimed to create a large database of the surgical outcomes of UC, present the trends of surgical procedures, and evaluate …
ERMAP attenuates DSS-induced colitis in mice by regulating macrophage and T cell functions
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40355813 DOI: 10.1186/s12876-025-03840-z
BACKGROUND & AIMS: Both macrophages and T cells play a critical role in inflammatory bowel disease (IBD) development. Since our previous studies have shown that a novel immune checkpoint molecule erythrocyte membrane-associated protein (ERMAP) affects macrophage polarization and negatively regulates T cell responses, we investigated the effects of ERMAP on …
Efficient diagnosis for endoscopic remission in Crohn's diseases by the combination of three non-invasive markers
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40355822
BACKGROUND: Serum C-reactive protein (CRP), leucine-rich alpha-2 glycoprotein (LRG), and fecal calprotectin (Fcal) are non-invasive markers used to assess Crohn's disease (CD) severity. However, the accuracy of these markers alone is often limited, and most previous reports have evaluated the efficacy of each marker individually. We aimed to improve the …
Milk peptides alleviate irritable bowel syndrome by suppressing colonic mast cell activation and prostaglandin E2 production in mice
Publication Year: 2025 Source: Food Res Int PMID: 40356133
This study aimed to investigate the effect of milk peptides on irritable bowel syndrome (IBS). The mice were intragastrally administered with casein or whey protein hydrolysates at a dose of 1 g/kg body weight/day for 24 days and were subjected to Citrobacter rodentium infection and water avoidance stress from day …
Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous Formulations
Publication Year: 2025 Source: Gut Liver PMID: 40356324
No Abstract
Weissella confusa alleviates experimental colitis in mice by regulating inflammatory pathways and gut microbiota
Publication Year: 2025 Source: Front Microbiol PMID: 40356657 DOI: 10.3389/fmicb.2025.1574548
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic condition with no cure. Probiotics may offer a new strategy for the treatment of IBD. Weissella confusa has been shown to have antibacterial, anti-inflammatory, and antioxidant beneficial effects in animal models. However, the anti-inflammatory effect of W. confusa at host cellular level …
Clinical relevance of inflammatory markers in the evaluation of severity of ulcerative colitis: A retrospective study
Publication Year: 2025 Source: Open Life Sci PMID: 40356724
This study aimed to investigate the clinical relevance of inflammatory markers in the severity assessment of ulcerative colitis (UC). The inflammatory markers included the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and calcium ion (Ca(2+)) levels. A retrospective analysis was on 110 patients with …
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