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Cytomegalovirus infection in patients with active ulcerative colitis: a prospective observational study
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 40359279
OBJECTIVES: The role of cytomegalovirus (CMV) infection in the course of inflammatory bowel disease is still controversial. We aimed to prospectively evaluate the course of ulcerative colitis in patients with exacerbation, in whom CMV status was examined using immunohistochemistry of bowel biopsies. METHODS: In a single centre, we followed-up consecutive …
The role of chest X-ray in detecting latent tuberculosis among patients with low-risk inflammatory bowel disease before advanced therapy
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 40359281 DOI: 10.1097/MEG.0000000000002975
BACKGROUND: Patients treated with biologics or Janus kinase (JAK) inhibitors have an increased risk of reactivating latent tuberculosis infection (LTBI). ECCO guidance recommends screening for LTBI by using clinical data, epidemiological factors, chest X-ray (CXR), and either a tuberculin skin test or interferon-gamma release assay (IGRA). The evidence supporting CXR …
Verapamil inhibits TXNIP-dependent NLRP3 Inflammasome activation in an ulcerative colitis rat model: A new evolving role of the calcium channel blocker
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40359884 DOI: 10.1016/j.intimp.2025.114751
Ulcerative colitis (UC) is a long-term inflammatory bowel disease (IBD) associated with significant morbidity. It is marked by inflammation and damage to the colon's mucosal lining. Studies have shown that NLRP3 inflammasome activation, apoptosis, and impaired autophagy are critical in its pathogenesis. Verapamil, a calcium channel blocker, has been found …
The prevalence of myasthenia gravis is increased in inflammatory bowel disease
Publication Year: 2025 Source: Arq Neuropsiquiatr PMID: 40360002 DOI: 10.1055/s-0045-1807717
Comorbid autoimmune disorders affect approximately 0.2% of the population. A second autoimmune disease occurs in up to 15% of myasthenia gravis (MG) patients.To evaluate the association between MG and inflammatory bowel disease (IBD).We conducted a cross-sectional study involving a Brazilian cohort of IBD patients and a literature review.In 2022, we …
NFE2L3 regulates inflammation and oxidative stress-related genes in the colon
Publication Year: 2025 Source: Biochim Biophys Acta Mol Cell Res PMID: 40360021 DOI: 10.1016/j.bbamcr.2025.119987
The molecular mechanisms leading to inflammatory bowel disease (IBD) are only partially understood. We investigated the role of the transcription factor NFE2L3 in a mouse model of colitis by inducing inflammation using dextran sodium sulfate (DSS). We confirmed the presence of inflammation by histological analysis and elevated levels of the …
Fecal metaproteomics enables functional characterization of remission in patients with inflammatory bowel disease
Publication Year: 2025 Source: J Proteomics PMID: 40360052 DOI: 10.1016/j.jprot.2025.105455
The gut microbiome is an important contributor to the development and the course of inflammatory bowel disease (IBD). While changes in the gut microbiome composition were observed in response to IBD therapy using biologics, studies elucidating human and microbial proteins and pathways in dependence on therapy success are sparse. Fecal …
Chinese yam (Dioscorea) polysaccharide ameliorates ulcerative colitis in mice via modulating disorders of intestinal microecology and metabolism
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40360104
Clinical research has demonstrated that non-starch polysaccharides from natural sources exhibit protective and therapeutic effects on ulcerative colitis (UC). In this study, a non-starch polysaccharide (CYP-A) with a molecular weight of 1.54 x 10(3) kDa was isolated from a speciality Chinese yam (Dioscorea) variety, the Ma yam, consisting mainly of …
Food-related Quality of Life in patients with Inflammatory Bowel Disease: Translation and Validation of the German version of FR-QoL-29
Publication Year: 2025 Source: Z Gastroenterol PMID: 40360140 DOI: 10.1055/a-2542-6781
The psychosocial effects of eating and drinking - summarized as food-related quality of life (FR-QoL) - are underexplored in inflammatory bowel disease (IBD). Currently, there is no German instrument to assess FR-QoL in IBD patients. This study aimed to translate the validated English FR-QoL-29 questionnaire into German and evaluate its …
Herpes zoster infection in patients with inflammatory bowel disease
Publication Year: 2025 Source: Korean J Intern Med PMID: 40360218 DOI: 10.3904/kjim.2024.342
No Abstract
Withdrawal of antitumour necrosis factor in patients with inflammatory bowel disease in remission: a randomised placebo-controlled clinical trial of GETECCU
Publication Year: 2025 Source: Gut PMID: 40360234 DOI: 10.1136/gutjnl-2025-334946
No Abstract
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