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Anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease
Publication Year: 2025 Source: Cochrane Database Syst Rev PMID: 40357993
BACKGROUND: Crohn's disease (CD) is a chronic inflammatory bowel disease leading to symptoms such as abdominal pain, diarrhea, weight loss, fatigue, and complications such as strictures and fistulas. Ustekinumab (CNTO 1275) and briakinumab (ABT-874) are monoclonal antibodies that target the standard p40 subunit of the cytokines interleukin-12 and interleukin-23 (IL-12/23p40), …
Chlorogenic acid and intestinal health: mechanistic insights and therapeutic applications
Publication Year: 2025 Source: Food Funct PMID: 40357998
Chlorogenic acid (CGA), a polyphenolic compound found in various plant species, has shown considerable potential in the treatment and management of several diseases due to its potent bioactive properties. Increasing evidence indicates that CGA exerts significant antioxidant, anti-inflammatory, and immunomodulatory effects by modulating key signaling pathways, including MAPK, PTEN/Akt, STAT3, …
Increased morbidities in pyoderma gangrenosum with extensive surgical debridement in Taiwan: a case series
Publication Year: 2025 Source: J Wound Care PMID: 40358224
OBJECTIVE: Delayed diagnosis and consequent extensive debridement in cases of pyoderma gangrenosum (PG) may lead to poor wound healing and unfavourable prognosis. We aimed to evaluate the epidemiological and clinical features of PG in Taiwan and investigate the clinical courses of patients who underwent extensive surgical debridement. METHOD: In this …
Methodological Considerations in the Increasing Rate of Hospitalization for IBD
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40358459 DOI: 10.14309/ajg.0000000000003470
No Abstract
[Transition in gastroenterology and hepatology]
Publication Year: 2025 Source: Inn Med (Heidelb) PMID: 40358755
Chronic diseases of the gastrointestinal tract or the liver manifest themselves in a significant number of patients as early as childhood or adolescence. The majority of these diseases require complex drug therapy and continuous care. This makes the transition to adult medicine all the more critical, as it is a …
Development of a Transcriptional Biosensor for Hydrogen Sulfide That Functions under Aerobic and Anaerobic Conditions
Publication Year: 2025 Source: ACS Synth Biol PMID: 40358934 DOI: 10.1021/acssynbio.5c00124
Hydrogen sulfide (H(2)S) is a gaseous gut metabolite with disputed effects on gastrointestinal health. Monitoring H(2)S concentration in the gut would provide insight into its role in disease but is complicated by sulfide's reactivity and volatility. Here we develop a transcriptional sulfide biosensor in Escherichiacoli. The sensor relies on enzymatic …
In vitro fermentation of yeast cell walls (mannan-oligosaccharide) and purified β-glucans modulates the colonic microbiota of dogs with inflammatory bowel disease and demonstrates protective effects on barrier integrity and anti-inflammatory properties
Publication Year: 2025 Source: PLoS One PMID: 40359204 DOI: 10.1371/journal.pone.0322877
Inflammatory bowel disease (IBD) is characterized by a disruption of intestinal homeostasis, chronic inflammation, and dysbiosis. Prebiotic supplementation may be useful for managing IBD in dogs. The aim of the study is to investigate the effects of two prebiotics, Biolex MB40 or Leiber Beta-S, on the gut microbiota isolated from …
Therapeutic application of nano-encapsulated pomegranate peel extract attenuated DSS-induced colitis: Antioxidant and anti-inflammatory role and reduction of exaggerated response of endoplasmic reticulum stress
Publication Year: 2025 Source: PLoS One PMID: 40359212 DOI: 10.1371/journal.pone.0323605
The medicinal application of pomegranate peel extract enriched with polyphenols (PPE) as a therapeutic strategy for managing inflammatory bowel diseases (IBD) is still limited. Integrating pomegranate peel extract (PPE) into an effective nanocarrier system could enhance its mechanistic actions, potentially aiding in the remission of colitis. Therefore, this approach aimed …
The impact of ethnicity on delays in initiating advanced therapy for inflammatory bowel disease
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 40359268 DOI: 10.1097/MEG.0000000000002995
OBJECTIVES: Prompt initiation of advanced therapy medications, encompassing biologics and small-molecule treatments, is crucial for the effective management of inflammatory bowel disease (IBD). The time taken from the decision to start an advanced therapy to the first administration, or time to advanced therapy (TAT), can vary significantly between individuals and …
Psychological symptoms and alexithymia in adolescents with inflammatory bowel diseases: a case-control study
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 40359271
INTRODUCTION: Little is known about thepsychological correlates of inflammatory bowel diseases (IBDs) in the pediatric population. We, therefore, conducted a case-control study systematically exploring psychopathological profiles and alexithymia in adolescents with IBDs. METHODS: We recruited 52 patients with IBDs (of whom 43 in clinical remission) and 52 age- and gender-matched …
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