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Fecal Arachidonic Acid: A Potential Biomarker for Inflammatory Bowel Disease Severity
Publication Year: 2025 Source: Int J Mol Sci PMID: 40362272 DOI: 10.3390/ijms26094034
Arachidonic acid levels are elevated in the colonic mucosa of patients with inflammatory bowel disease (IBD). Fecal metabolites are emerging as valuable diagnostic tools for IBD. This study aimed to investigate associations between 31 fecal fatty acids, including arachidonic acid, to identify potential correlations with disease severity. Among the 31 …
Autoantibody Profiling in Ulcerative Colitis: Identification of Early Immune Signatures and Disease-Associated Antigens for Improved Diagnosis and Monitoring
Publication Year: 2025 Source: Int J Mol Sci PMID: 40362323 DOI: 10.3390/ijms26094086
Ulcerative colitis (UC) is a major form of inflammatory bowel disease (IBD) characterised by chronic immune-mediated inflammation. While serological biomarkers for IBD diagnosis and differentiation have been explored, autoantibody-based profiling remains underdeveloped. This study aimed to elucidate antibody signatures in manifested and pre-diagnostic UC patients compared to controls using a …
Crosstalk Between Bile Acids and Intestinal Epithelium: Multidimensional Roles of Farnesoid X Receptor and Takeda G Protein Receptor 5
Publication Year: 2025 Source: Int J Mol Sci PMID: 40362481 DOI: 10.3390/ijms26094240
Bile acids and their corresponding intestinal epithelial receptors, the farnesoid X receptor (FXR), the G protein-coupled bile acid receptor (TGR5), play crucial roles in the physiological and pathological processes of intestinal epithelial cells. These acids and receptors are involved in the regulation of intestinal absorption, signal transduction, cellular proliferation and …
miR-369-3p Ameliorates Inflammation and Apoptosis in Intestinal Epithelial Cells via the MEK/ERK Signaling Pathway
Publication Year: 2025 Source: Int J Mol Sci PMID: 40362525 DOI: 10.3390/ijms26094288
Inflammatory Bowel Disease (IBD) is a group of chronic and recurrent inflammatory diseases characterized by prolonged inflammation of the intestinal tract. Although it has been proven that the immune system plays a crucial role in the pathogenesis of IBD, a defective intestinal epithelium is also responsible for chronic inflammation, hence …
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Publication Year: 2025 Source: Nutrients PMID: 40362741 DOI: 10.3390/nu17091425
Inflammatory bowel disease (IBDs), including Crohn's disease (CD), and ulcerative colitis (UC) are complex diseases with a multifactorial etiology, associated with genetic, dietetic, and other environmental risk factors. Children with IBD are at increased risk for nutritional inadequacies, resulting from decreased oral intake, restrictive dietary patterns, malabsorption, enhanced nutrient loss, …
Enteral Nutrition in Crohn's Disease: A Comprehensive Review of Its Role in Induction and Maintenance of Remission and Perioperative Management in Adult Patients
Publication Year: 2025 Source: Nutrients PMID: 40362790
Crohn's disease (CD) is a chronic inflammatory bowel disorder frequently associated with significant nutritional deficiencies. Enteral nutrition (EN), particularly exclusive enteral nutrition (EEN), has gained recognition not only for its nutritional support but also for its therapeutic potential in reducing intestinal inflammation. While EEN is well established in pediatric populations, …
NSAIDs, Ileal Inflammation, and Glucose Metabolism: Insights from a Large Retrospective Cohort
Publication Year: 2025 Source: Nutrients PMID: 40362822 DOI: 10.3390/nu17091514
BACKGROUND/OBJECTIVES: Ileitis, or inflammation of the terminal ileum, is often linked to inflammatory bowel disease (IBD), especially Crohn's disease, but may also arise from non-steroidal anti-inflammatory drug (NSAID) use. While NSAIDs are known to cause gastrointestinal injury, their role in ileitis and downstream metabolic consequences remains unclear. This study evaluated …
Practical Application of Evidence-Based Dietary Therapy in Inflammatory Bowel Disease: The DELECTABLE Program
Publication Year: 2025 Source: Nutrients PMID: 40362901 DOI: 10.3390/nu17091592
BACKGROUND/OBJECTIVES: Exclusive Enteral Nutrition (EEN) and the Crohn's Disease Exclusion Diet (CDED) have been shown to induce remission in Crohn's disease. Low-sulphur, plant-based diets are being explored for ulcerative colitis, and wholefood, low-additive approaches are emerging as significant. Although Inflammatory Bowel Disease (IBD) patients modify their diet, evidence for tolerability …
Colon-Targeted Mucoadhesive PLGA Microspheres Loaded with Ramulus Mori Alkaloids for Enhanced Water-Soluble Drug Delivery in Ulcerative Colitis Treatment
Publication Year: 2025 Source: Molecules PMID: 40363686
Ulcerative colitis (UC) is a chronic inflammation disease with severe impact on quality of life, with limited treatment options. Ramulus Mori alkaloids (SZ-A) from Morus alba show promise for UC treatment due to their safety and pharmacological effects, including anti-inflammation and barrier repair. However, their clinical use has been limited …
Drug Repurposing to Inhibit Oncostatin M in Crohn's Disease
Publication Year: 2025 Source: Molecules PMID: 40363705 DOI: 10.3390/molecules30091897
Crohn's disease is an inflammatory bowel disease (IBD) that currently lacks satisfactory treatment options. Therefore, new targets for new drugs are urgently needed to combat this disease. In the present study, we investigated the transcriptomics-based mRNA expression of intestinal biopsies from patients with Crohn's disease. We compared the mRNA expression …
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