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Use of Metabolic Scores and Lipid Ratios to Predict Metabolic Dysfunction-Associated Steatotic Liver Disease Onset in Patients with Inflammatory Bowel Diseases
Publication Year: 2025 Source: J Clin Med PMID: 40364004 DOI: 10.3390/jcm14092973
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized in inflammatory bowel disease (IBD) patients due to chronic inflammation and metabolic disturbances. However, reliable non-invasive biomarkers for MASLD prediction in this population are lacking. This study evaluated the predictive value of metabolic scores and lipid ratios for MASLD onset …
Repurposing Atorvastatin, HMGCO-A Reductase Inhibitor, in Patients with Ulcerative Colitis: A Randomized Controlled Study
Publication Year: 2025 Source: J Clin Med PMID: 40364108
Background/Objective: Among the inflammatory bowel illnesses, ulcerative colitis (UC) affects 5 million people worldwide. UC manifests as weight loss, rectal bleeding, persistent diarrhea, and abdominal pain. Experimental research focused into the potential benefits of atorvastatin for colitis, although the literature only has a small amount of clinical evidence. To examine …
Use of Intraoperative Ultrasonography of the Small Bowel to Reduce Histologically Positive Margins in Crohn's Disease Surgery: A Pilot Study
Publication Year: 2025 Source: J Clin Med PMID: 40364165 DOI: 10.3390/jcm14093135
Background/Objectives: The histological involvement of surgical resection margins in Crohn's disease (CD) is an important risk factor for postoperative recurrence. The aim of this study was to evaluate the usefulness of intraoperative ultrasonography (IOUS) of the small bowel to best identify the surgical site of resection and reduce the rate …
Nutritional Deficiencies and Reduced Bone Mineralization in Ulcerative Colitis
Publication Year: 2025 Source: J Clin Med PMID: 40364233 DOI: 10.3390/jcm14093202
Background: Inadequate dietary intake of vitamin D, vitamin K, and calcium, as well as sub-optimal sunlight exposure, can lead to bone loss in the general population, and more so in patients with ulcerative colitis, who are burdened by additional predisposing factors for osteoporosis, such as chronic inflammation and cortisone use. …
Engineering the microbiome: A novel frontier in inflammatory bowel disease treatment
Publication Year: 2025 Source: Chin Med J (Engl) PMID: 40364490
No Abstract
Inflammatory bowel disease is a conundrum
Publication Year: 2025 Source: Chin Med J (Engl) PMID: 40364512
No Abstract
Reliability of patient-reported pain and discharge for predicting perianal lesions in pediatric Crohn's disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40364578
Over 40% of children with Crohn's disease (CD) develop perianal lesions (skin tags and/or fissures), which are associated with the risk of perianal fistula. It is unknown how reliably perianal symptoms predict perianal lesions. We recruited pediatric patients with CD who were undergoing colonoscopy for clinical indications. Patients self-reported recent …
Atractylenolide-1 Alleviates Ulcerative Colitis via Restraining RhoA/ROCK/MLC Pathway-Mediated Intestinal Barrier Dysfunction
Publication Year: 2025 Source: J Agric Food Chem PMID: 40364748
Using Atractylenolide-1 (AT-1) is a confident strategy for the treatment of ulcerative colitis (UC) due to its natural origin and notable pharmacological activity. The study investigated the therapeutic effect of AT-1 in dextran sodium sulfate (DSS)-induced mice and Caco-2 cells while also exploring the underlying molecular mechanisms. In this study, …
Oral Extraintestinal Manifestations of Inflammatory Bowel Disease: The Temporal Relationship Between Oral and Intestinal Symptoms
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40364799 DOI: 10.1093/crocol/otaf027
OBJECTIVES: Oral extraintestinal manifestations (OEIMs) of inflammatory bowel disease (IBD) may impact IBD treatment. The aims of this study were to: (1) determine which OEIMs are most prevalent among patients with IBD, (2) investigate the presence of a temporal association between GI luminal disease activity and OEIMs, and (3) determine …
US and European Patient and Health Care Professional Perspectives on Fatigue in Ulcerative Colitis and Crohn's Disease: Results From the Communicating Needs and Features of Inflammatory Bowel Disease Experiences Survey
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40364800
BACKGROUND: Fatigue is a burdensome symptom of Crohn's disease (CD) and ulcerative colitis (UC). The Communicating Needs and Features of Inflammatory Bowel Disease Experiences (CONFIDE) study investigated how patients and health care professionals (HCPs) in the United States (US) and Europe (France, Germany, Italy, Spain, and the United Kingdom) perceived …
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