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Intraoperative Autologous Platelet-Rich Stroma Injection as Add-On to Fistula Curettage and Closure of the Internal Orifice Demonstrates a Favorable Outcome in Long-Term in Patients Suffering from Therapy-Refractory Perianal Fistulizing Crohn's Disease

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40411444

BACKGROUND: An injection with autologous platelet-rich stroma (PRS), a combination of stromal vascular fraction and platelet-rich plasma, as an add-on to fistula curretage and closure of the internal orifice proved to be safe and feasible for the treatment of patients with treatment-refractory perianal fistulizing Crohn's disease (pCD). This study aimed …

Incidence and Risk Factors for Development of Acne (JAKne) in Patients with Inflammatory Bowel Disease Treated With Upadacitinib

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40411447

No Abstract

Myeloperoxidase Enzyme Activity in Feces Reflects Endoscopic Severity in Inflammatory Bowel Disease

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40411448 DOI: 10.1093/ibd/izaf109

BACKGROUND: Concentrations of the neutrophil protein myeloperoxidase are elevated in the feces of individuals with endoscopically active inflammatory bowel disease (IBD). Its enzyme activity could give an immediate readout of endoscopic inflammation. We investigated whether fecal myeloperoxidase activity (fMPOa) is associated with IBD endoscopic inflammation. We also investigated whether myeloperoxidase …

Structural Bowel Disease: Not a Barrier to Transmural Healing With IUS

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40411450

No Abstract

Plasma Calprotectin and Myeloperoxidase as Biomarkers in Inflammatory Bowel Disease

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40411452 DOI: 10.1093/ibd/izaf110

BACKGROUND: Inflammatory bowel disease (IBD) is a relapsing-remitting illness requiring proactive monitoring of gut inflammation. We aimed to determine the correlations of plasma myeloperoxidase (pMPO) and calprotectin (pCal), two neutrophil proteins, with existing measures of disease activity. METHODS: Adults with IBD undergoing ileocolonoscopy were recruited prospectively. Baseline assessments included blood …

Rectal and Rectosigmoid Endoscopy to Assess Endoscopic and Histological Remission in Ulcerative Colitis: A Prospective Study

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40411471

BACKGROUND AND AIMS: Despite increasing interest in endoscopic and histological remission as a treatment target in ulcerative colitis (UC), the accuracy of endoscopic and histological findings in the left colon and/or rectum to detect pancolonic remission is poorly known. We aimed to compare the diagnostic accuracy of rectosigmoidoscopy (RS) and …

Therapeutic potential of Janus kinase inhibitors for the management of fibrosis in inflammatory bowel disease

Publication Year: 2025 Source: J Crohns Colitis PMID: 40411492 DOI: 10.1093/ecco-jcc/jjaf087

Intestinal fibrosis in inflammatory bowel disease (IBD) is caused by uncontrolled accumulation of extracellular matrix deposited by fibroblasts. This may result in stricture formation, especially in Crohn's disease. Since there are no anti-fibrotic drugs available, endoscopic or surgical interventions are the only options to treat intestinal strictures. The Janus kinase-signal …

A Narrative Review of Pemphigoid Diseases: Bridging Associations, Comorbidities, and Management

Publication Year: 2025 Source: Dermatol Ther (Heidelb) PMID: 40411679 DOI: 10.1007/s13555-025-01444-9

Pemphigoid diseases are a group of rare, chronic autoimmune blistering disorders (AIBD) characterized by subepidermal blister formation due to autoantibody-mediated targeting of structural components of the basement membrane zone (BMZ). This narrative review provides an updated overview of four key subtypes: bullous pemphigoid (BP), mucous membrane pemphigoid (MMP), linear IgA …

Changdiqing decoction (CDQD) ameliorates colitis via suppressing inflammatory macrophage activation and modulating gut microbiota

Publication Year: 2025 Source: Phytomedicine PMID: 40412060

BACKGROUND: Ulcerative colitis (UC) is a non-specific inflammatory bowel disease. Unlike any single form of cell death reported previously, macrophage PANoptosis, a unique programmed cell death characterized by inflammation and necrosis, plays a crucial role in the pathogenesis of colitis. Changdiqing Decoction (CDQD), an empirical hospital prescription enema, has been …

Psychological well-being is the major determinant of global health in the first year following a diagnosis of inflammatory bowel disease in children

Publication Year: 2025 Source: J Psychosom Res PMID: 40412339 DOI: 10.1016/j.jpsychores.2025.112142

Inflammatory bowel disease (IBD) represents a group of disorders with no known cure. IBD is impacted by biopsychosocial factors. The burden, psychosocial difficulties, and gene-environment interaction involved in the manifestation of IBD necessitate a fuller understanding of factors which worsen or ameliorate IBD. Case complexity (CC) captures current and historical …

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