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Baicalein alleviates chronic acute stress-induced irritable bowel syndrome-like symptoms in rats via modulating the ODC1/NF-κB pathway and oxidative stress
Publication Year: 2025 Source: Biochem Biophys Res Commun PMID: 40409117
BACKGROUND: As a persistent gastrointestinal disorder, irritable bowel syndrome (IBS) influences the gut-brain connection, leading to abdominal pain and altered bowel irregularities. Baicalein, a flavonoid extracted from Scutellaria baicalensis, is frequently utilized in anti-inflammatory treatments. This study aimed to explore baicalein's effectiveness in mitigating IBS symptoms triggered by both chronic …
Colitis induced ventricular alternans increases the risk for ventricular arrhythmia
Publication Year: 2025 Source: J Mol Cell Cardiol PMID: 40409406
Inflammatory bowel disease was linked to an increased risk for conduction defects and ventricular arrhythmia. It coincides with dysregulation of gut microbiota, increased inflammation, and deregulation of the renin-angiotensin system. In this study, we aimed to determine the mechanism of colitis-induced electrophysiological remodeling that increases the risk for ventricular arrhythmia. …
Camptothecin-loaded chondroitin sulfate-celecoxib reduction-sensitive micelles for enhanced colon cancer treatment
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40409631 DOI: 10.1016/j.ijbiomac.2025.144489
Studies have shown that inflammation is closely linked to the cancer development, and the patients with inflammatory bowel disease (IBD) have a higher risk of colon cancer. Celecoxib (CXB) and camptothecin (CPT) showed potential treatment for IBD and colon cancers, respectively. However, their applications are limited by synchronous delivery, water …
Cutaneous malignancy after biologic therapy for inflammatory disease: An active comparator, retrospective cohort study
Publication Year: 2025 Source: J Am Acad Dermatol PMID: 40409718
BACKGROUND: The role biologics play in skin cancer among patients with inflammatory disease (ID) is uncertain. Skin cancer risk in patients with ID is elevated regardless of therapy, and there is a paucity of longitudinal data evaluating biologics that accounts for these ID-related confounders. OBJECTIVE: To assess the risk of …
Reply to "Comment on "Exacerbated gastrointestinal symptoms and long COVID in IBD patients with SARS-CoV-2 infection: A multi-center study from Taiwan""
Publication Year: 2025 Source: J Formos Med Assoc PMID: 40410115 DOI: 10.1016/j.jfma.2025.05.023
No Abstract
Delivery of bone marrow mesenchymal stem cell-derived exosomes into fibroblasts attenuates intestinal fibrosis by weakening its transdifferentiation via the CCN2-TGF-β axis
Publication Year: 2025 Source: Sci Rep PMID: 40410354
Intestinal fibrosis represents a clinically intractable complication in colitis management. This study elucidates the regulatory mechanisms by which bone mesenchymal stem cell-derived exosomes (BMSC-Exo) modulate the myofibroblastic transdifferentiation of intestinal fibroblast. BMSC-Exo was isolated and characterized. RNA sequencing was performed on TGF-beta-activated CCD-18Co fibroblasts following BMSC-Exo intervention. Histopathology, immunoblotting, migration …
Fast simulation of identity-by-descent segments
Publication Year: 2025 Source: Bull Math Biol PMID: 40410602 DOI: 10.1007/s11538-025-01464-8
The worst-case runtime complexity to simulate haplotype segments identical by descent (IBD) is quadratic in sample size. We propose two main techniques to reduce the compute time, both of which are motivated by coalescent and recombination processes. We provide mathematical results that explain why our algorithm should outperform a naive …
Association of Vascular Cell Adhesion Molecule-1 Expression in Colonic Mucosa With Mucosal Inflammation and Subsequent Relapse in Patients With Ulcerative Colitis
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 40411296
BACKGROUND AND AIM: The association between vascular cell adhesion molecule-1 (VCAM-1) expression and intestinal mucosal inflammation and between VCAM-1 expression and the clinical course in patients with ulcerative colitis (UC) remains unclear. Therefore, we investigated not only the association between mucosal VCAM-1 expression and mucosal inflammation but also its association …
Increased mucosal and T-cell expression of 4-1BB and PD-1 are modulated by anti-TNFα treatment in Crohn's disease
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40411404
OBJECTIVE: Pro-inflammatory T-cell responses dominate in Crohn's disease (CD). This may result from a dysbalanced expression of co-stimulatory and inhibitory T-cell receptors. The present study investigated if a dysbalanced co-stimulatory and inhibitory T-cell receptor expression are present in CD and can be rebalanced by anti-TNFalpha treatment. METHODS: Mucosal biopsies from …
First Documented Case of Successful Dual Therapy With Upadacitinib and Mirikizumab for Multi-Refractory Ulcerative Proctitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40411442 DOI: 10.1093/ibd/izaf113
No Abstract
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