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Surgery combined endoscopic stricturotomy for deep small bowel strictures from Crohn' disease: a prospective, single-center cohort study of a novel approach
Publication Year: 2025 Source: Surg Endosc PMID: 40425860
BACKGROUND AND AIMS: A common complication which can influence the prognosis of Crohn's disease (CD) is multi-segmental strictures, and there are limitations to using either surgical or endoscopic treatment alone. We aimed to treat multi-segmental strictures in CD using combination of surgery and endoscopic therapy and to evaluate the efficacy …
A rare case of bronchial stenosis in ulcerative colitis
Publication Year: 2025 Source: BMC Pulm Med PMID: 40426091 DOI: 10.1186/s12890-025-03639-4
BACKGROUND: Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract with increasing incidence worldwide. Though primarily affecting the digestive system, IBD can lead to extraintestinal manifestations, including rare respiratory complications. CASE PRESENTATION: In our case report, we present the case of a 56-year-old …
Genetic Variants in Early-Onset Inflammatory Bowel Disease: Monogenic Causes and Clinical Implications
Publication Year: 2025 Source: Children (Basel) PMID: 40426715 DOI: 10.3390/children12050536
Background/Objectives: This study aims to identify genetic variants associated with early-onset inflammatory bowel disease (IBD) and to improve diagnostic and therapeutic approaches. In selected monogenic IBD cases, treatment included colchicine, interleukin-1 inhibitors, and hematopoietic stem cell transplantation. Methods: This study included patients with early-onset IBD, defined as IBD diagnosed before …
Family Factors and the Psychological Well-Being of Children and Adolescents with Inflammatory Bowel Disease-An Exploratory Study
Publication Year: 2025 Source: Children (Basel) PMID: 40426755 DOI: 10.3390/children12050575
Background/Objectives: The aim of our study was to examine the influence of family structure and the number of siblings on psychological problems and illness-related emotions in children and adolescents with inflammatory bowel disease (IBD) and the relationship between emotional coping in children and parents. Methods: CEDNA is a nationwide German …
Patient Empowerment Among Children and Adolescents with Inflammatory Bowel Disease (IBD) and Parents of IBD Patients-Use of Counseling Services and Lack of Knowledge About Transition
Publication Year: 2025 Source: Children (Basel) PMID: 40426799 DOI: 10.3390/children12050620
Background: Children and adolescents with pediatric inflammatory bowel diseases (PIBD) face significant challenges, including emotional stress, social isolation, and interrupted education due to symptoms. Effective counseling and education empower these young patients and their families to actively participate in healthcare. This paper investigates the IBD needs analysis (CEDNA), focusing on …
Infliximab Biosimilar Utilization in a Large Pediatric Learning Health System
Publication Year: 2025 Source: Children (Basel) PMID: 40426835 DOI: 10.3390/children12050656
Background/Objectives: Infliximab biosimilars entered the United States (US) market in November 2016. Uptake of infliximab biosimilars has been slow in adult studies. We aimed to assess variation in the initiation of infliximab biosimilars in a large pediatric cohort. Methods: We performed a retrospective cohort study using data from 2016 to …
GLP-1R Agonists and Their Therapeutic Potential in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases, a Systematic Review of the Literature
Publication Year: 2025 Source: Biomedicines PMID: 40426955 DOI: 10.3390/biomedicines13051128
Background/Objectives: GLP-1 receptor agonists (GLP-1RAs) have revolutionized weight loss and shown anti-inflammatory actions in several experimental models of colitis. There has been a wealth of recent data suggesting that GLP-1RA treatment may modify disease outcomes in inflammatory bowel disease (IBD). The aim of this systematic review is to determine if …
Angiogenic Factors and Inflammatory Bowel Diseases
Publication Year: 2025 Source: Biomedicines PMID: 40426981 DOI: 10.3390/biomedicines13051154
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is characterized by chronic intestinal inflammation and impaired epithelial barrier function. Emerging evidence highlights the critical role of vascular remodeling and angiogenesis in IBD pathogenesis. This review explores the intricate relationship between blood vessels and the intestinal epithelial barrier, emphasizing …
Accuracy of Imaging Scoring Indexes in Pediatric Crohn's Disease Patients
Publication Year: 2025 Source: Biomedicines PMID: 40426984
Background: Crohn's disease (CD) is a chronic inflammatory condition that can affect the gastrointestinal tract and cause significant extraintestinal manifestations. Diagnosing and monitoring disease activity, especially in pediatric patients, remains a challenge due to the variable clinical presentations and limitations of traditional imaging methods. Objective: This study aimed to evaluate …
Advanced Therapies for Inflammatory Bowel Disease and Risk of Skin Cancer: What's New?
Publication Year: 2025 Source: Cancers (Basel) PMID: 40427207 DOI: 10.3390/cancers17101710
Introduction: The introduction of biologic therapies and small molecule drugs has revolutionized the management of inflammatory bowel disease (IBD), providing targeted control of inflammation. However, concerns remain regarding their long-term safety profiles, particularly in relation to cancer risk. Chronic inflammation and immunosuppressive therapies contribute to malignancy risk, including skin cancers, …
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