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Neutrophils at the Crossroads of Inflammatory Bowel Disease and Atherosclerosis: A State-of-the-Art Review
Publication Year: 2025 Source: Cells PMID: 40422241 DOI: 10.3390/cells14100738
Inflammatory bowel disease (IBD) is a growing global problem, particularly in regions with low sociodemographic indices and growing populations. IBD incidence is increasing among children and adolescents, leading to a growing economic burden. The prevalence of atherosclerotic cardiovascular diseases among patients with IBD is also higher than in the general …
Nutrition in Inflammatory Bowel Disease: Strategies to Improve Prognosis and New Therapeutic Approaches
Publication Year: 2025 Source: Diseases PMID: 40422571 DOI: 10.3390/diseases13050139
Inflammatory Bowel Disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory condition of the gastrointestinal tract that significantly impacts nutritional status. Malnutrition is a frequent complication, resulting from reduced nutrient intake, malabsorption, and increased metabolic demands due to chronic inflammation. A comprehensive nutritional assessment encompassing …
Gut Mycobiome: Latest Findings and Current Knowledge Regarding Its Significance in Human Health and Disease
Publication Year: 2025 Source: J Fungi (Basel) PMID: 40422666 DOI: 10.3390/jof11050333
The gut mycobiome, the fungal component of the gut microbiota, plays a crucial role in health and disease. Although fungi represent a small fraction of the gut ecosystem, they influence immune responses, gut homeostasis, and disease progression. The mycobiome's composition varies with age, diet, and host factors, and its imbalance …
Listening Beyond the Symptoms: Existential Needs and Identity in Older Adults With Inflammatory Bowel Disease
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40423522
No Abstract
Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia
Publication Year: 2025 Source: Elife PMID: 40424190 DOI: 10.7554/eLife.103047
Understanding the genetic diversity and transmission dynamics of Plasmodium falciparum, the causative agent of malaria, is crucial for effective control and elimination efforts. In some endemic regions, malaria is highly seasonal with no or little transmission during up to 8 mo, yet little is known about how seasonality affects the …
Improved detection of microbiome-disease associations via population structure-aware generalized linear mixed effects models (microSLAM)
Publication Year: 2025 Source: PLoS Comput Biol PMID: 40424276 DOI: 10.1371/journal.pcbi.1012277
Microbiome association studies typically link host disease or other traits to summary statistics measured in metagenomics data, such as diversity or taxonomic composition. But identifying disease-associated species based on their relative abundance does not provide insight into why these microbes act as disease markers, and it overlooks cases where disease …
Flos lonicerae polysaccharide alleviates inflammatory bowel disease by improving intestinal microbiota and inhibiting oxidative stress and the NF-κB pathway
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40424651 DOI: 10.1016/j.intimp.2025.114956
Inflammatory bowel disease (IBD) is a chronic disease that is increasingly being recognized globally. IBD is difficult to cure and is in urgent need of more treatment options. Flos lonicerae polysaccharide (FLP) is an effective component extracted from traditional Chinese medicine flos lonicerae, and previous studies have demonstrated its therapeutic …
Using novel approaches to conjugate peptides of Macrotermes bellicosus and Curcuma longa for targeted intervention of irritable bowl diseases caused by tumor necrosis factor superfamily member 15 (TNFSF15)
Publication Year: 2025 Source: Mol Immunol PMID: 40424787 DOI: 10.1016/j.molimm.2025.05.018
This study presents an in-silico approach to develop targeted therapies for Irritable Bowel Disease (IBD) by focusing on TNFSF15. Peptides derived from Macrotermes bellicosus and Curcuma longa were selected, conjugated with the 50S ribosomal protein L7/L12 adjuvant, and analyzed for immunogenic potential. Gene expression analysis showed differential TNFSF15 expression in …
Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
Publication Year: 2025 Source: Transl Oncol PMID: 40424934 DOI: 10.1016/j.tranon.2025.102431
Colitis-associated colorectal cancer (CAC), which stems from inflammatory bowel disease (IBD), exhibits a high mortality rate. Chronic inflammation can drive the development of colorectal cancer via diverse mechanisms; however, proteomic-level studies in this regard are currently scarce. The chemical drugs conventionally employed for treating IBD carry significant side effects, accentuating …
Thetis cells: regulators of intestinal immune tolerance
Publication Year: 2025 Source: Curr Opin Immunol PMID: 40424976
Our body's mucosal surfaces interface with the external environment and are potential sites of entry for pathogens as well as noxious substances. Yet, these barrier sites are also colonized with symbiotic microbes and are in contact with harmless environmental antigens. Different barrier epithelia harbor distinct microbial communities that shape both …
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