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Probiotic Potential of Pediococcus pentosaceus M6 Isolated from Equines and Its Alleviating Effect on DSS-Induced Colitis in Mice
Publication Year: 2025 Source: Microorganisms PMID: 40431130
Colitis in equines has high morbidity and mortality rates, which severely affects the development of the equine-breeding industry. With the issuance of antibiotic bans, there is an urgent need for healthier and more effective alternatives. In recent years, probiotics have been widely used as microbial feed additives in animal husbandry, …
Personalized Microbiome Modulation to Improve Clinical Outcomes in Pediatric Inflammatory Bowel Disease: A Multi-Omics and Interventional Approach
Publication Year: 2025 Source: Microorganisms PMID: 40431220 DOI: 10.3390/microorganisms13051047
Inflammatory bowel disease (IBD) is a complex disorder influenced by genetic, environmental, and microbial factors, with emerging evidence highlighting the gut microbiome's role in disease pathogenesis. This study investigates the impact of microbiome-targeted interventions in pediatric IBD by integrating multi-omics analysis, including metagenomics, metabolomics, transcriptomics, and clinical biomarkers, to identify …
Moderate Wine Consumption and Gastrointestinal Diseases
Publication Year: 2025 Source: Nutrients PMID: 40431349 DOI: 10.3390/nu17101608
By conducting a narrative review of the scientific literature, the authors of this study sought to verify whether there were sufficient data to answer the following question: "Can wine positively or negatively influence the incidence and severity of disorders associated with gastrointestinal (GI) diseases?". In this review, most of the …
Crohn's Disease Patients Referred for Home Parenteral Nutrition-A Comprehensive Analysis of 18 Years' Experience at a National Reference Centre
Publication Year: 2025 Source: Nutrients PMID: 40431437
Background: Within 10 years of diagnosis, about 50% of patients with Crohn's disease (CD) require surgery. Repeated small bowel resections can lead to the development of short bowel syndrome (SBS). It is estimated that 65-75% of CD patients are malnourished. This retrospective observational study was conducted in a Polish reference …
"Inside the Gut-Brain Axis": Psychological Profiles of Adolescents with Inflammatory Bowel Diseases and with Restrictive Eating Disorders
Publication Year: 2025 Source: Nutrients PMID: 40431446
Background: Individuals with inflammatory bowel diseases (IBDs) have an increased risk of developing psychiatric co-morbidities, including restrictive eating disorders (REDs), with which they share common pathogenic mechanisms, including gut-brain axis dysregulation. We conducted a case-control study systematically exploring the psychopathological profiles and alexithymia in adolescents with IBDs compared with a …
Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial
Publication Year: 2025 Source: Nutrients PMID: 40431448
BACKGROUND: The disruption of the intestinal barrier and the imbalance of the gut microbiota (GM) seem to play a major role in the complex pathogenesis of irritable bowel syndrome (IBS). Specific microbial strains could improve the gut microenvironment, promoting anti-inflammatory pathways; similarly, vitamin D supplementation could play a role in …
Protective effects of dill fruit against acute acetic acid-induced ulcerative colitis by reducing inflammation and oxidative stress in rats
Publication Year: 2025 Source: Physiol Rep PMID: 40432400
Nutritherapy is the art of using nutrients as a means of preventing or correcting dysfunction in the body. We aimed to evaluate the protective effect of dill fruit aqueous extract (DFAE) against acetic acid-induced ulcerative colitis. Healthy male rats (N = 42) were divided into seven groups of six animals …
Podophyllotoxin Alleviates DSS-Induced Ulcerative Colitis via PI3K/AKT Pathway Activation
Publication Year: 2025 Source: Physiol Res PMID: 40432443
This study systematically evaluated the therapeutic effects of podophyllotoxin in a DSS-induced mouse model of ulcerative colitis. A total of 374 podophyllotoxin-related targets were identified through database screening, and by intersecting them with 1,741 UC-related targets, 120 potential therapeutic targets were obtained. Subsequent GO and KEGG enrichment analyses revealed that …
Access to Diverse Activatable Heptamethine Cyanine Probes with Low Intrinsic Fluorescence via 5-exo-trig Cyclization Strategy for High-Contrast Bioimaging In Vivo
Publication Year: 2025 Source: Angew Chem Int Ed Engl PMID: 40432579 DOI: 10.1002/anie.202423059
The conversion of conventional "always-on" cyanine dyes into activatable NIR probes with low inherent fluorescence remains challenging, resulting in poor imaging contrast and nonspecific response in vivo. We herein report a 5-exo-trig cyclization strategy to create diverse activatable heptamethine cyanine probes with "zero" intrinsic background fluorescence for high-contrast bioimaging. This …
Tracking Oral Nanoparticle Uptake in Mouse Gastrointestinal Tract by Fluorescent Labeling and t-SNE Flow Cytometry
Publication Year: 2025 Source: Bio Protoc PMID: 40432753 DOI: 10.21769/BioProtoc.5309
The growing demand for advanced analytical techniques to explore complex cellular targets of nanotherapeutics has driven the development of innovative methodologies. This protocol presents a refined approach for fluorescent labeling and flow cytometric analysis of colonic cells following oral lipid nanoparticle (LNP) treatment, focusing on LNP uptake in colonic cell …
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