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Investigating the Causality and Pathogenesis of Primary Sclerosing Cholangitis in Colorectal Cancer Through Mendelian Randomization and Bioinformatics
Publication Year: 2025 Source: Genet Res (Camb) PMID: 40432804 DOI: 10.1155/genr/5887056
Introduction: The relationship between autoimmune diseases and cancer risk has been increasingly studied. Colorectal cancer, a common malignancy with high morbidity and mortality, has been closely linked to inflammatory bowel disease (IBD) in previous research. However, the association and pathogenesis between primary sclerosing cholangitis (PSC) in autoimmune diseases and colorectal …
Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing
Publication Year: 2025 Source: Front Immunol PMID: 40433374
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by dysregulated immune responses, resulting in sustained inflammation and ulceration of the colonic and rectal mucosa. To elucidate the cellular subtypes and gene expression profiles implicated in the pathogenesis of UC, we utilized single-cell and spatial transcriptomic analyses. METHODS: …
"Remodeling the intestinal immune microenvironment": immune regulation and tissue regeneration by mesenchymal stem/stromal cells in the repair microenvironment of inflammatory bowel disease
Publication Year: 2025 Source: Front Immunol PMID: 40433382 DOI: 10.3389/fimmu.2025.1543702
The global prevalence of inflammatory bowel disease (IBD) has significantly increased in recent decades. IBD is a long-term, recurring, gastrointestinal inflammatory condition that mainly comprises two primary clinical types: ulcerative colitis and Crohn's disease. The current treatment paradigm for IBD primarily focuses on symptom management. However, this approach does not …
[Recurrent thrombosis despite oral anticoagulation? A case report]
Publication Year: 2025 Source: Praxis (Bern 1994) PMID: 40433720
We describe a 34-year-old female patient with recurrent thromboembolic events, most recently with occlusion of the superior mesenteric vein - despite regular intake of oral anticoagulation with Apixaban at the dosage recommended by the manufacturer. The underlying cause was enteral malabsorption with protein loss syndrome due to active Crohn's disease, …
Dihydroartemisinin Alleviates Ulcerative Colitis via Target Identification and Pathway Modulation: A Cyberpharmacology Approach
Publication Year: 2025 Source: Biotechnol Appl Biochem PMID: 40433891
Ulcerative colitis (UC) is a long-term inflammatory condition impacting the bowel with an unclear cause. It is categorized as a refractory condition due to the limited efficacy and adverse effects of existing treatments. Dihydroartemisinin (DHA), a semi-synthetic derivative and primary active metabolite of artemisinin, exhibits anti-inflammatory and antioxidant properties. To …
Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis
Publication Year: 2025 Source: J Exp Med PMID: 40434419
Innate lymphoid cells (ILCs) are long-lived, tissue-resident cell analogs to T helper subsets that lack antigen-specific receptors. Understanding the roles of specific ILCs in chronic inflammation and fibrosis has been limited by inadequate tools for selective targeting. Here, we used Il17rb-CreERT2-eGFP and Rorc-Cre strains to selectively delete RORalpha in ILC2s …
JAK-STAT inhibitors in noninfectious uveitis - A review
Publication Year: 2025 Source: Indian J Ophthalmol PMID: 40434456
The management of noninfectious uveitis (NIU) has involved the use of corticosteroids and immunomodulators (IMT). However, a certain subset of NIU patients does not respond to conventional IMT therapy, such as methotrexate and azathioprine. In these patients, biological IMT with specific targets is employed. One such example is the use …
Mesenchymal stem/stromal cells-derived exosomes: possible therapeutic mechanism in inflammatory bowel disease
Publication Year: 2025 Source: Hum Cell PMID: 40434563 DOI: 10.1007/s13577-025-01243-6
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract caused by dysfunction of the immune system in genetically susceptible individuals. As current pharmacologic and surgical treatments remain suboptimal, increasing attention has been directed toward exosomes derived from mesenchymal stem/stromal cells (MSCs) as alternative therapeutic approaches. MSCs …
Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling
Publication Year: 2025 Source: Proc Natl Acad Sci U S A PMID: 40434646
Interleukin (IL)-23 is a validated therapeutic target in inflammatory bowel disease. While antibodies targeting IL23 demonstrate clinical efficacy, they face challenges such as high costs, safety risks, and the necessity of parenteral administration. Here, we present a workflow to simultaneously enhance the affinity and protease stability of an inhibitory anti-IL23R …
Quantified motility in Crohn's disease to evaluate stricture composition using cine-MRI
Publication Year: 2025 Source: Br J Radiol PMID: 40434919
OBJECTIVES: The histopathological composition of a stricture impacts clinical treatment choice. Therefore, imaging biomarkers that can distinguish a predominantly inflammatory from a chronic (ie non-inflammatory) stricture are highly relevant. The aim of our study was to determine whether it is possible to distinguish inflammatory (ie inflammatory and mixed) from chronic …
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