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Multi-Functional Applications of Hydrogel Delivery Systems in Inflammatory Bowel Disease: Drug Delivery, Anti-Inflammation, and Intestinal Repair
Publication Year: 2025 Source: Polymers (Basel) PMID: 40508675 DOI: 10.3390/polym17111430
Inflammatory bowel disease (IBD) represents a chronic inflammatory disorder of the gastrointestinal tract with a multifactorial etiology that remains incompletely elucidated. Accumulating evidence implicates dysregulation of the intestinal micro-ecosystem, aberrant neuroimmune interactions, and compromised epithelial barrier integrity as key contributors to IBD pathogenesis. While oral administration remains the predominant therapeutic …
Serum proteomic and metabolomic analyses from patients with IBD identify biological pathways associated with treatment success with anti-integrin therapy
Publication Year: 2025 Source: Immunol Cell Biol PMID: 40509637 DOI: 10.1111/imcb.70039
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract believed to arise from an imbalance between its epithelial, immune and microbial components. It has been shown that biological differences (e.g. genetic, epigenetic, microbial, environmental) exist between patients with IBD. It is also known that …
Protective Properties of the White Button Mushroom, Agaricus bisporus, in a Mouse Model of Colitis
Publication Year: 2025 Source: Mol Nutr Food Res PMID: 40509652
Previous work demonstrated the promising immunomodulatory potential of a naturally derived whole mushroom powder (WMP) from the white button mushroom, Agaricus bisporus. Here, we further investigate the protective properties of WMP in a mouse model of colitis. An in vitro digested WMP (IVD-WMP) reduced permeability of intestinal epithelial Caco-2 and …
Colon Enzyme-Activated Prebiotic Nanomedicine for Targeted Therapy of Inflammatory Bowel Disease
Publication Year: 2025 Source: Small Methods PMID: 40509675 DOI: 10.1002/smtd.202401408
Inflammatory bowel disease is commonly treated with conventional therapies that suffer from poor drug bioavailability and significant side effects. This work develops a nanoparticle system using inulin, a naturally occurring polysaccharide, to address these challenges. This colon-targeted oral drug delivery system enables precise and efficient treatment of IBD by leveraging …
Gut microbiome signatures predict 5-ASA efficacy in ulcerative colitis
Publication Year: 2025 Source: iScience PMID: 40510115
Ulcerative colitis (UC) prevalence is rising globally, yet fewer than 50% of patients achieve mucosal healing (MH) with first-line 5-aminosalicylic acid (5-ASA) therapy. We aimed to identify microbial signatures that could predict the treatment efficacy of 5-ASA. Active UC patients on standardized 5-ASA treatment were prospectively enrolled. Shotgun metagenomic sequencing …
A review of thalidomide and digestive system related diseases
Publication Year: 2025 Source: Front Oncol PMID: 40510146
Thalidomide, once discovered and used to treat pregnancy sickness, fell out of favor with teratogenicity scandals, and then re-entered the public eye with its amazing efficacy against leprosy and multiple myeloma, and its anti-tumor and anti-inflammatory effects were gradually discovered. In recent years, thalidomide has also begun to gain prominence …
Perioperative factors and outcomes associated with antimicrobial therapy duration in horses undergoing exploratory celiotomy
Publication Year: 2025 Source: Can Vet J PMID: 40510283
OBJECTIVE: The objective was to compare perioperative factors that may influence clinician decisions regarding antimicrobial therapy duration and outcomes in horses undergoing exploratory celiotomy. ANIMALS: Horses > 1 mo of age undergoing exploratory celiotomy for colic that survived without repeat celiotomy for >/= 5 d. PROCEDURE: Retrospective cohort study. Cases …
Identification of miRNAs associated with eosinophilic esophagitis shown by esophageal mucosal biopsy results of Japanese patients
Publication Year: 2025 Source: J Clin Biochem Nutr PMID: 40510385
No Abstract
The early-life gut microbiome in common pediatric diseases: roles and therapeutic implications
Publication Year: 2025 Source: Front Nutr PMID: 40510495
The early-life gut microbiome has been increasingly recognized as a contributing factor for pediatric health and diseases. Studies have reported that the human gut microbiota colonization commences at birth and progresses over the course of the first three years of life, until it reaches a mature and stable diversity and …
Exploring the multidimensional impact of caregiver burden in patients with inflammatory bowel disease
Publication Year: 2025 Source: Front Public Health PMID: 40510583 DOI: 10.3389/fpubh.2025.1528778
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory condition characterized by periods of relapse and remission, often requiring frequent medical visits. Family members, who are central to the patient's social support network, often serve as primary caregivers, facing significant physiological, psychological, and financial strain. However, research on caregiver …
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