Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Etrasimod: Modulating Sphingosine-1-Phosphate Receptors to Treat Ulcerative Colitis
Publication Year: 2025 Source: J Clin Med PMID: 40507651
This review aimed to provide a comprehensive overview of the current landscape of etrasimod. Etrasimod is an oral, once-daily selective modulator of sphingosine 1-phosphate receptors (S1PR), developed for the treatment of moderately to severely active ulcerative colitis and currently being explored for its potential in other immune-mediated inflammatory diseases. It …
Assessment of Bone Health in Adult Patients with Inflammatory Bowel Disease: A Single-Center Cohort Study
Publication Year: 2025 Source: J Clin Med PMID: 40507698 DOI: 10.3390/jcm14113933
Background: Most of the studies that have investigated bone quality in inflammatory bowel disease (IBD) have utilized dual-energy X-ray absorptiometry (DXA). We assessed the bone status of IBD adult patients using a comprehensive array of non-invasive techniques. Methods: Fifty IBD patients (30 women) and 50 healthy volunteers-matched for age, gender, …
Information Needs of Patients with Inflammatory Bowel Disease in the Digital Era: A 20-Year Longitudinal Study
Publication Year: 2025 Source: J Clin Med PMID: 40507700 DOI: 10.3390/jcm14113939
Background: Chronic inflammatory bowel disease significantly impacts patients' everyday lives. Despite receiving regular medical care in gastroenterological or family medicine consultations, patients with inflammatory bowel disease (IBD) still experience a lack of information. To evaluate these deficits, we analyzed the main points of interest raised in an online consultation forum …
Endometriosis and Nutrition: Therapeutic Perspectives
Publication Year: 2025 Source: J Clin Med PMID: 40507748
Endometriosis is a chronic, hormone-dependent disorder characterized by an inflammatory response. The disease affects approximately 10% of the general female population, with prevalence rates reaching 30-40% in women with dysmenorrhea and 50-60% in those experiencing infertility. In addition to pelvic pain and reproductive issues, gastrointestinal symptoms, such as acute abdominal …
Corporal Composition and Gut Microbiome Modification Through Exclusion Dietary Intervention in Adult Patients with Crohn's Disease: Protocol for a Prospective, Interventional, Controlled, Randomized Clinical Trial
Publication Year: 2025 Source: J Clin Med PMID: 40507757
Background: Crohn's disease (CD) is an inflammatory bowel disease in which there is an alteration in the homeostasis and functionality of the intestinal mucosa accompanied by a dysbiosis of the commensal microbiota. The analysis of different dietary strategies to achieve CD remission and reduce gastrointestinal symptoms concludes that it is …
Elastographic Histogram Analysis as a Non-Invasive Tool for Detecting Early Intestinal Remodeling in Experimental IBD
Publication Year: 2025 Source: J Clin Med PMID: 40507760 DOI: 10.3390/jcm14113992
Background/Objectives: Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is characterized by cycles of inflammation and tissue remodeling that can culminate in fibrosis. Differentiating between early inflammatory and fibrotic bowel wall changes remains a diagnostic challenge due to overlapping imaging features. This study aimed to assess the potential …
Inflammatory Bowel Disease (IBD)-Associated Colorectal Cancer (CRC): Is cGAS-STING Pathway Targeting the Key to Chemoprevention?
Publication Year: 2025 Source: Int J Mol Sci PMID: 40507791 DOI: 10.3390/ijms26114979
Inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) remains a significant clinical challenge due to its link with chronic inflammation and the inherent limitations of current prevention and surveillance strategies. The cGAS-STING pathway has emerged as a key player in the immune regulation of inflammation-driven carcinogenesis, demonstrating both protective and pathogenic …
Integrating Proteomics into Personalized Medicine for Inflammatory Bowel Disease-Reality or Challenge?
Publication Year: 2025 Source: Int J Mol Sci PMID: 40507799 DOI: 10.3390/ijms26114993
Inflammatory bowel diseases (IBD) represent chronic conditions with etiopathogenic mechanisms incompletely elucidated despite extensive research efforts. Therefore, it is essential for clinical monitoring of the implementation of personalized medicine, enabling risk stratification and the selection of therapies with the highest likelihood of a favorable response. Multi-omics approaches have emerged as …
TL1A as a Target in Inflammatory Bowel Disease: Exploring Mechanisms and Therapeutic Potential
Publication Year: 2025 Source: Int J Mol Sci PMID: 40507829 DOI: 10.3390/ijms26115017
Inflammatory bowel diseases (IBD) are chronic disorders characterized by persistent inflammation of the gastrointestinal tract. Despite advances in treatment, a significant proportion of patients remain refractory to current therapies and develop complications, particularly fibrosis, leading to strictures and fistulae. Tumor necrosis factor-like ligand 1A (TL1A) has emerged as a promising …
Glucosinolates from Broccoli By-Products Obtained by Pressurized Liquid Extraction Exert Anti-Inflammatory Activity on Non-Malignant Colonic Myofibroblasts
Publication Year: 2025 Source: Plants (Basel) PMID: 40508374
Broccoli agro-industries generate a significant amount of waste, which leads to both environmental and economic problems. These by-products are typically discarded, despite being a valuable source of bioactive compounds, including glucosinolates (GSLs), which can modulate oxidant and inflammatory mediators, exerting anti-inflammatory properties. A crucial challenge in the exploitation of broccoli …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide