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Gaps between European Crohn's Colitis Organisation quality standards of care and the real world on structure of IBD units across Europe: results from E-QUALITY survey
Publication Year: 2025 Source: J Crohns Colitis PMID: 40512137 DOI: 10.1093/ecco-jcc/jjaf094
BACKGROUND AND AIMS: Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, require an interdisciplinary approach for diagnosis, monitoring, and management. The European Crohn's and Colitis Organisation (ECCO) has developed evidence-based recommendations and quality care standards for IBD management, but gaps between these standards and real-world practice persist.The E-QUALITY …
Effectiveness and safety of intravenous iron in ulcerative colitis: A real-world study of impact of disease activity and iron preparations
Publication Year: 2025 Source: Indian J Gastroenterol PMID: 40512340
BACKGROUND: There is lack of evidence on how disease activity in inflammatory bowel disease influences response to intravenous iron. METHODS: A single-centre prospective study was conducted to study responses to intravenous iron in ulcerative colitis. Patients with iron deficiency anemia (hemoglobin < 8 g/dL OR < 12 g/dL with intolerance …
Maternal vitamin D regulates the metabolic rearrangement of offspring CD4(+) T cells in response to intestinal inflammation
Publication Year: 2025 Source: Cell Rep PMID: 40512616
Children with autism spectrum disorders often have increased susceptibility to intestinal inflammation. However, the mechanisms and prevention of gastrointestinal immune dysfunction remain unclear. We demonstrate that maternal high vitamin D (VitD) level can rescue abnormal intestinal immune phenotypes in offspring that exhibit autism-like phenotypes due to exposure to maternal inflammation. …
A randomized controlled trial of antibiotics targeting adherent and invasive Escherichia coli versus placebo in Crohn's disease: the TEOREM trial
Publication Year: 2025 Source: J Crohns Colitis PMID: 40512677
BACKGROUND: A subset of patients with ileal Crohn's disease (CD) are colonized with adherent-invasive Escherichia coli (AIEC). OBJECTIVE: This prospective trial tested the efficacy of antibiotics for endoscopic response in CD patients colonized with AIEC. DESIGN: Patients with endoscopically active, ileal CD, colonized with AIEC, were randomized to receive oral …
Oral delivery of tunable oxidation-responsive budesonide-loaded nanoparticles enhances inflammation modulation in intestinal colitis
Publication Year: 2025 Source: J Control Release PMID: 40513667 DOI: 10.1016/j.jconrel.2025.113948
The rising global prevalence and socio-economic impact of Inflammatory Bowel Disease (IBD) highlight the pressing demand of innovative solutions. Drug-targeting technologies are urgently needed to effectively deliver drugs directly to the affected areas of the gastrointestinal tract (GIT). In this work, a surface-tunable nanosystem responsive to reactive oxygen species (ROS) …
Local recurrence rates of horizontal margin-positive en bloc endoscopic submucosal dissection of colorectal neoplasia: a meta-analysis
Publication Year: 2025 Source: Gastrointest Endosc PMID: 40513803 DOI: 10.1016/j.gie.2025.05.035
BACKGROUND AND AIMS: Endoscopic Submucosal Dissection (ESD) enables en bloc resection of large colorectal neoplasms, but the recurrence risk with positive or indeterminate horizontal margins (HM1/x) remains debated. This meta-analysis evaluated the local recurrence rate following en bloc ESD with HM1/x margins. METHODS: A systematic search of PubMed, EMBASE, Web …
Usefulness of the Screening Tool for AdheRence to medicineS (15-STARS) in clinical practice: Subset-analysis of a multicentric study with inflammatory bowel disease (IBD) patients
Publication Year: 2025 Source: Res Social Adm Pharm PMID: 40514277 DOI: 10.1016/j.sapharm.2025.06.001
INTRODUCTION: The 15-STARS questionnaire (Screening Tool for AdheRence to medicineS) is a validated self-report screening tool that assesses modifiable determinants of medication non-adherence. It was applied in the 5C-study with chronic inflammatory bowel diseases (IBD) patients in Basel, Switzerland during the winters 2022/23 and 2023/24. Its usefulness, defined as data …
Cerebral Crohn's Disease-Not Your Typical Brain-Gut Connection
Publication Year: 2025 Source: Dig Dis Sci PMID: 40514635
No Abstract
Unmet health-related needs in patients with Crohn's disease in Belgium: a mixed-methods study
Publication Year: 2025 Source: Arch Public Health PMID: 40514703 DOI: 10.1186/s13690-025-01632-1
BACKGROUND: Measuring health-related unmet needs is crucial for identifying innovation gaps and developing targeted strategies to address them. This study focused on measuring the unmet needs of patients with Crohn's disease in Belgium using a standardised methodology that can facilitate comparisons across different diseases. Crohn's disease is a chronic condition …
Primary Gastrointestinal Iatrogenic Kaposi Sarcoma: A Rare Pediatric Case Report
Publication Year: 2025 Source: Pediatr Dev Pathol PMID: 40515487
Kaposi sarcoma (KS) is a rare, human herpesvirus-8 (HHV-8)-associated vascular tumor that primarily affects the skin but can involve visceral organs, particularly in immunosuppressed patients. While iatrogenic KS is well-documented in adults, isolated gastrointestinal involvement in pediatric cases remains unreported. We describe a 16-year-old HIV-negative male with chronic granulomatous disease …
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