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Frequent Dietetic Involvement Enhances Adherence and Clinical Outcomes of Exclusive Enteral Nutrition in Adults With Crohn's Disease
Publication Year: 2025 Source: JGH Open PMID: 40625826
BACKGROUND AND AIM: Use of Exclusive Enteral Nutrition (EEN) in adults has been limited by lack of defined protocols, poor adherence and perceived lack of efficacy. This study evaluated EEN therapy in adults with Crohn's disease (CD) to identify determinants of clinical efficacy, adherence, and therapy completion. METHODS: This retrospective, …
Construct Validity of the Toronto IBD Global Endoscopic Reporting Score Compared to Inflammatory Biomarkers After 12-Month Follow-Up
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40626945
BACKGROUND AND AIMS: The Toronto IBD Global Endoscopic Reporting (TIGER) score is a single endoscopic scoring index for both patients with Crohn's disease (CD) and ulcerative colitis (UC). The goal of this study was to assess the direct relationship between TIGER scores and fecal calprotectin (FC) and C-reactive protein (CRP) …
Increasing age at diagnosis raises malignancy risk and aminosalicylate intolerance influences therapeutic strategies in ulcerative colitis: a multicenter I‑BRITE cohort study
Publication Year: 2025 Source: J Gastroenterol PMID: 40627077
BACKGROUND: The management and characteristics of ulcerative colitis (UC) have evolved over time. We aimed to clarify how changing clinical profiles and treatment options affect patient outcomes. METHODS: This retrospective multicenter study of 13 hospitals divided diagnostic era into six periods: Era 1 (before June 30, 1998) and five subsequent …
Interleukin-37 polymorphism (rs3811047) in Egyptian patients with ulcerative colitis
Publication Year: 2025 Source: Mol Biol Rep PMID: 40627226
BACKGROUND: Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), is characterized by dysregulated mucosal immune responses. Although the precise cause of ulcerative colitis is yet unknown, immune system disruptions, environmental factors, and genetic predispositions all play a role in its pathogenesis. In an Egyptian patient population, this study is …
Assessment of duodenal villous morphology in canine IBD using magnification endoscopy with water immersion technique (WIT) and image skeletonization
Publication Year: 2025 Source: Vet Res Commun PMID: 40627228
Inflammatory Bowel Disease (IBD) is an idiopathic disorder characterized by chronic, nonspecific gastrointestinal signs. Gastrointestinal endoscopy with histopathology is the gold standard for confirming inflammation and assessing severity. Although endoscopic criteria for IBD in dogs exist, detailed evaluation of duodenal villi morphology remains limited. In human medicine, magnification endoscopy with …
Health Maintenance and Unique Health Needs of the Perimenopausal and Postmenopausal Woman with Inflammatory Bowel Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40627279
No Abstract
The Significance of STAT3 in Colonic Diseases: A Comprehensive Study of Pathological Roles and Therapeutic Implications
Publication Year: 2025 Source: Cell Biochem Biophys PMID: 40627320
The transcriptional regulator signal transducer and activator of transcription 3 (STAT3) plays pivotal roles in vertebrate development and the functionality of mature tissues, particularly in modulating inflammation and immune responses. Mutations in STAT3 in humans are associated with various diseases, including immunodeficiencies, autoimmune disorders, and multiple cancers. Notably, both aberrant …
Pyoderma Gangrenosum in Pregnancy: A Systematic Review of Clinical Characteristics, Treatment Outcomes, and Maternofetal Implications
Publication Year: 2025 Source: J Drugs Dermatol PMID: 40627582
BACKGROUND: Although cases of pyoderma gangrenosum (PG) during pregnancy have been reported, comprehensive data are limited. This review aims to (1) analyze the demographic and clinical characteristics of PG in pregnant and postpartum patients, (2) assess the frequency and effectiveness of treatments, and (3) explore the maternal and fetal implications …
Epigenomic Control of Immunity: From Mechanisms to Therapeutic Targets in Inflammatory Bowel Diseases
Publication Year: 2025 Source: Int Immunol PMID: 40627746
This review presents an overview of the emerging roles of epigenomic regulation in immune cell function, with a particular focus on its relevance in inflammatory bowel disease (IBD). Epigenetic mechanisms, including DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs, are essential in directing immune cell development, activation, and lineage …
Cirsiliol alleviates experimental inflammatory bowel disease via restoration of intestinal barrier integrity and inhibition of NF-κB and MAPK pathways
Publication Year: 2025 Source: Sci Rep PMID: 40629068
Inflammatory bowel disease (IBD) involves chronic gut inflammation and barrier damage. While natural flavonoids show promise for IBD treatment, cirsiliol's effects were unknown. This study examined cirsiliol's therapeutic potential in mice with DNBS-induced colitis and its mechanisms in vitro and in vivo. Mice received either ethanol (vehicle), DNBS, or cirsiliol …
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