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AQP9 and IFITM1 as drivers of immune infiltration and tumor progression in IBD-associated colorectal cancer: from computational insights to experimental validation
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 40622593
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract associated with an increased risk of colorectal cancer. Despite extensive research, high treatment failure rates have intensified the search for new therapeutic and diagnostic biomarkers. This study used an integrative approach, combining gene expression analysis with machine …
Recombinant Herpes Zoster Vaccine Lowers Shingles Complication Risk in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 40623013
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at increased risk of herpes zoster (HZ) due to innate immune abnormalities in patients with IBD and use of immunosuppressive therapy. The recombinant zoster vaccine (RZV) is recommended, but its efficacy in preventing recurrent HZ among patients with IBD is not well …
Correction: Withdrawal of antitumour necrosis factor in inflammatory bowel disease patients in remission: a randomised placebo-controlled clinical trial of GETECCU
Publication Year: 2025 Source: Gut PMID: 40623728
No Abstract
Histological differentiation of inflammatory bowel disease from "diverticular colitis": an actual possibility or the fog is still thick?
Publication Year: 2025 Source: Virchows Arch PMID: 40624173
No Abstract
Bowel function and quality of life after robotic and laparoscopic IPAA: a patient-reported outcomes study
Publication Year: 2025 Source: J Robot Surg PMID: 40624405
BACKGROUND: Minimally invasive ileal pouch-anal anastomosis (IPAA) has become the standard of care for patients with ulcerative colitis or familial adenomatous polyposis, offering numerous benefits over open surgery. However, the impact of robotic surgery on long-term quality of life (QoL) remains poorly defined. OBJECTIVE: To analyze QoL after robotic and …
Exposure to advanced therapies and risk of surgery in Crohn's disease
Publication Year: 2025 Source: Surg Endosc PMID: 40624415
BACKGROUND & AIMS: While advancements in therapeutic options for inflammatory bowel disease reduced rates of surgical resection, some patients still require surgery despite multiple lines of medical therapies. This study investigates the relationship between the number, class, and progression rate of different advanced therapies (AT) and risk of surgical resection …
Impact of restorative proctocolectomy for ulcerative colitis on service retention in the US military
Publication Year: 2025 Source: Surg Endosc PMID: 40624419
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that affects military service members with potential for involuntary medical separation. This study investigates functional return to duty after restorative proctocolectomy in active-duty service members. METHODS: This retrospective study utilized data from the Medical Assessment and Readiness System at Womack …
The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis
Publication Year: 2025 Source: Gut Microbes PMID: 40624731
Inflammatory bowel disease (IBD) patients often exhibit expansion of the gut pathobiont, adherent-invasive E. coli (AIEC). Loss of activity of the IBD susceptibility gene, protein tyrosine phosphatase type 2 (PTPN2), causes gut microbiota dysbiosis in IBD patients, while Ptpn2 knock-out (Ptpn2-KO) mice display AIEC expansion. CEACAM6, a host cell surface …
Management of comorbid Crohn's disease and alopecia universalis with upadacitinib and oral minoxidil
Publication Year: 2025 Source: J Dermatolog Treat PMID: 40625127
PURPOSE: This study describes the use of upadacitinib, a JAK1 inhibitor, in combination with oral minoxidil for treatment of alopecia universalis (AU) with comorbid Crohn's disease (CD) and atopic dermatitis (AD). AU is the most extensive form of alopecia areata (AA), a chronic autoimmune condition that often requires systemic therapy …
Evaluation of Patients With Iron Deficiency Anaemia Referred via the Colorectal Cancer Two-Week Pathway in a District General Hospital: A Retrospective Cohort Study
Publication Year: 2025 Source: Cureus PMID: 40625469
Background Iron deficiency anaemia (IDA) is a frequent clinical presentation in both primary and secondary care and is a recognised red-flag symptom for underlying gastrointestinal malignancy, particularly colorectal cancer. Prompt and efficient investigation is essential to identify significant pathology while minimising unnecessary procedures. Objectives To evaluate the clinical outcomes of …
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