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Faecal mucoprotein MUC2 is decreased in multiple sclerosis and is associated with mucin degrading bacteria
Publication Year: 2025 Source: EBioMedicine PMID: 40344717 DOI: 10.1016/j.ebiom.2025.105721
BACKGROUND: The gut microbiome is altered in MS and may contribute to disease by disrupting the intestinal barrier. The colonic mucus barrier, which is primarily composed of mucin protein 2 (MUC2), plays a crucial role in providing a barrier between colonic epithelial cells and the microbiome. Disruption of intestinal epithelial …
The potential mechanism of co-administration of Scutellaria baicalensis Georgi and Rubia cordifolia L ameliorating ulcerative colitis: Integration of metabolomics, network pharmacology, and molecular docking
Publication Year: 2025 Source: J Pharm Biomed Anal PMID: 40344969
Scutellaria baicalensis Georgi (HQ) and Rubia cordifolia L. (QC) are clinically effective against ulcerative colitis (UC), but their synergistic mechanisms remain unclear. This study evaluated the therapeutic effects of HQ, QC, and their combination (HQ-QC) in dextran sulfate sodium (DSS)-induced colitis and explored underlying mechanisms. Mice were divided into normal, …
From traditional to artificial intelligence-driven approaches: Revolutionizing personalized and precision nutrition in inflammatory bowel disease
Publication Year: 2025 Source: Clin Nutr ESPEN PMID: 40345659 DOI: 10.1016/j.clnesp.2025.05.012
Inflammatory bowel disease (IBD), comprising ulcerative colitis and Crohn's disease, is a chronic inflammatory condition with global prevalence and varying incidence. The IBD pathogenesis involves intricate interactions among genetic, host and environmental factors, leading to dysregulated immune responses and chronic intestinal inflammation. Alongside elevated levels of inflammatory cytokines and altered …
Glycyrrhiza pallidiflora Polysaccharide Ameliorates DSS-Induced Colitis by Protecting Intestinal Barrier Integrity
Publication Year: 2025 Source: Cell Biochem Biophys PMID: 40346348
Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease. Glycyrrhiza pallidiflora polysaccharide (GPP) is an important constituent of a species of Glycyrrhiza pallidiflora, but its therapeutic mechanism in UC mice is not clear. A dextran sulphate sodium salt (DSS)-induced mouse model of UC was established, and GPP was extracted by …
Care needs profiles of Crohn's disease patients and their associations with symptom clusters, post-traumatic growth, and family function: a latent profile analysis
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40346452 DOI: 10.1186/s12876-025-03953-5
BACKGROUND AND AIMS: The care needs of patients with Crohn's disease (CD) may be heterogeneous. This study aimed to explore the latent class of care needs of patients with CD and differences in their characteristics and to analyze the factors influencing the different latent classes. METHODS: A convenience sampling method …
Prolonged time to treatment of biologics in inflammatory bowel disease: disparities from a retrospective study in a tertiary referral centre in the UK
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40346554 DOI: 10.1186/s12876-025-03909-9
BACKGROUND: Several disparities in healthcare utilisation and delivery are reported in inflammatory bowel disease (IBD). We examined disparities for delays in biologic administration. METHODS: This is a tertiary centre, retrospective, cohort study of consecutive adult IBD outpatients referred to the biologics clinic (BC) for initiation of therapy over 2 years. …
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages
Publication Year: 2025 Source: Stem Cell Res Ther PMID: 40346712 DOI: 10.1186/s13287-025-04365-8
BACKGROUND: Inflammatory bowel disease (IBD), a chronic immune disorder, has increasing global incidence and poor treatment outcome. Abnormal macrophage function is implicated in the pathophysiology of IBD. In this study, we investigated the mechanism by which human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) inhibit inflammation in IBD mouse and …
Second-line strategies after anti-TNF failure in chronically active, moderate-to-severe ulcerative colitis: a retrospective, multicentre cohort study
Publication Year: 2025 Source: Expert Opin Biol Ther PMID: 40346848 DOI: 10.1080/14712598.2025.2500962
BACKGROUND: Many ulcerative colitis (UC) patients require the use of second-line agents after the failure of anti-TNF therapy. RESEARCH DESIGN AND METHODS: We conducted a multicenter, retrospective study including 683 chronically active, moderate-to-severe UC patients who failed first-line anti-TNFs. The rate of treatment persistence and colectomy-free survival was assessed up …
Factors affecting response rates in patient-reported outcome measures in inflammatory bowel disease
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40346869 DOI: 10.1080/00365521.2025.2501070
BACKGROUND: Inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC), are associated with reduced quality of life (QoL). By using questionnaire tools called patient-reported outcome measures (PROM), patients' well-being and health-status can be measured. The aim of this study was to identify subgroups at risk of being missed in …
Downregulation of METTL3 enhances TRADD-mediated apoptosis in inflammatory bowel disease
Publication Year: 2025 Source: Sci China Life Sci PMID: 40347213 DOI: 10.1007/s11427-024-2799-6
Dysregulation of RNA N(6)-methyladenosine (m(6)A) modification in intestinal epithelial cells (IECs) compromises intestinal homeostasis, which is critical for maintaining gastrointestinal functions, immunity, and barrier integrity in inflammatory bowel disease (IBD). Here we explored the role of m(6)A modification, particularly through methyltransferase like 3 (METTL3), in IBD pathology and the apoptosis …
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