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Combination of probiotics enhancing butyrogenesis in colonic microbiota model of patients with ulcerative colitis
Publication Year: 2025 Source: Appl Microbiol Biotechnol PMID: 40347262
Administering beneficial bacteria as probiotics to restore the intestinal microbiota and its metabolic functions, such as butyrogenesis, is a promising treatment strategy in ulcerative colitis (UC). This study aimed to investigate the effect of a combination of probiotics, consisting of the lactic acid bacterium Weizmannia coagulans SANK70258 and the lactate-utilizing …
Radiomics prediction of surgery in ulcerative colitis refractory to medical treatment
Publication Year: 2025 Source: Tech Coloproctol PMID: 40347388
BACKGROUND: The surgeries in drug-resistant ulcerative colitis are determined by complex factors. This study evaluated the predictive performance of radiomics analysis on the basis of whether patients with ulcerative colitis in hospital were in the surgical or medical treatment group by discharge from hospital. METHODS: This single-center retrospective cohort study …
A literature review on the role of artificial intelligence-based chatbots in patient education in colorectal surgery
Publication Year: 2025 Source: Surgery PMID: 40347684
INTRODUCTION: Artificial intelligence-based chatbots are becoming increasingly used in patient education, in the realm of colorectal diseases. Perhaps, not surprisingly, concerns about the appropriateness of chatbot answers have been raised by healthcare professionals. Numerous studies have explored the utility and accuracy of chatbots in providing information in several clinical disciplines. …
The pitfalls and promises of scoping reviews in gastroenterology literature - Authors' reply
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 40347956
No Abstract
Long-term efficacy and safety of upadacitinib in patients with moderately to severely active ulcerative colitis: an interim analysis of the phase 3 U-ACTIVATE long-term extension study
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 40347957
BACKGROUND: The U-ACTIVATE long-term extension study aims to evaluate the long-term efficacy and safety of upadacitinib in patients with moderately to severely active ulcerative colitis. Here, we report interim results after 3 years of total treatment. METHODS: U-ACTIVATE is an ongoing, 288-week, phase 3, long-term extension study done at 307 …
Pro-inflammatory macrophages contribute to developing comorbid anxiety-like behaviors through gastrointestinal vagal afferent signaling in experimental colitis mice
Publication Year: 2025 Source: Brain Behav Immun PMID: 40348137 DOI: 10.1016/j.bbi.2025.05.007
No Abstract
A bigel co-delivering highly hydrophilic and hydrophobic natural compounds for enhanced ulcerative colitis therapy
Publication Year: 2025 Source: Int J Pharm PMID: 40348303
Bigel, formed by high-speed shearing of hydrogel and oleogel, is suited to deliver both lipophilic and hydrophilic active compounds. Patchouli oil and paeoniflorin, despite their potential in treating ulcerative colitis, face challenges due to patchouli oil's poor aqueous solubility and paeoniflorin's high solubility but low permeability. In this study, we …
Optimizing Therapeutic Potential of Fecal Transplant in Inflammatory Bowel Disease
Publication Year: 2025 Source: Gastroenterol Clin North Am PMID: 40348488 DOI: 10.1016/j.gtc.2024.12.002
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract influenced by genetic, environmental, immune, and microbial factors. Reduced gut microbial diversity and elevated proinflammatory bacteria levels in IBD disrupt mucosal immunity, barrier function, and inflammatory pathways. Fecal microbiota transplantation (FMT) is a potential therapy to restore …
Beyond Random Fecal Microbial Transplants: Next Generation Personalized Approaches to Normalize Dysbiotic Microbiota for Treating IBD
Publication Year: 2025 Source: Gastroenterol Clin North Am PMID: 40348491 DOI: 10.1016/j.gtc.2024.11.002
This review and commentary outline the strong rationale for normalizing the abnormal microbiota of patients with ulcerative colitis, Crohn's disease, and pouchitis and focus on strategies to improve current variable outcomes of fecal microbial transplant (FMT) in ulcerative colitis. Applying lessons from successful FMT therapy of recurrent Clostridioides difficile and …
Understanding Microbial Mediation of the Brain-Gut Axis
Publication Year: 2025 Source: Gastroenterol Clin North Am PMID: 40348493
Bidirectional communications between the gut and the brain play an important role in the regulation of food intake, pain perception, mood, and cognitive function. The involved communication pathways are modulated by signals generated by the gut microbiome. Alterations in these communications have been implicated in several chronic brain and gut …
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