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Lizhong decoction alleviates experimental ulcerative colitis via regulating gut microbiota-SCFAs-Th17/Treg axis
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40350047
ETHNOPHARMACOLOGICAL RELEVANCE: Lizhong decoction (LZD), a Traditional Chinese Medicine formula, is widely utilized to treat gastrointestinal diseases, including ulcerative colitis in China for thousands of years. AIM OF THE STUDY: To investigate whether the protective effect of LZD on ulcerative colitis is dependent on gut microbiota and T-cell immune homeostasis. …
Clinician management of patients with Crohn's-related perianal fistulas: results of a multispecialty case-based survey
Publication Year: 2025 Source: BMJ Open Gastroenterol PMID: 40350167
OBJECTIVE: A case-based survey was conducted to identify practice patterns and knowledge gaps in the management of Crohn's perianal fistulas (CPF) and to further understand approaches to CPF management within the USA by healthcare professionals (HCPs) from different specialties. METHODS: The web-based survey, comprising two hypothetical patient case vignettes (case …
[What disease presents with abdominal pain and bloody stools coupled with significant eosinophilia?]
Publication Year: 2025 Source: Nihon Shokakibyo Gakkai Zasshi PMID: 40350317
No Abstract
Safety and efficacy of elafibranor in primary sclerosing cholangitis: The ELMWOOD phase II randomized-controlled trial
Publication Year: 2025 Source: J Hepatol PMID: 40350321
BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is a rare, chronic liver disease. Elafibranor, a dual peroxisome proliferator-activated receptor-alpha/delta agonist, was investigated in the phase II ELMWOOD trial (NCT05627362). METHODS: This 12-week, double-blind trial enrolled adults with PSC and alkaline phosphatase (ALP) >/=1.5x the upper limit of normal. The primary …
A case report of mesalazine alleviating diarrhea in a patient with nasopharyngeal cancer after tislelizumab treatment
Publication Year: 2025 Source: Immunotherapy PMID: 40350385
Immunotherapy has become a significant research focus for cancer treatment in recent years because it can generate enduring immunological responses and has promising therapeutic potential. Nevertheless, excessive stimulation of the immune system may adversely affect healthy organs, which can lead to immune-related toxicities, including gastrointestinal, pulmonary, hepatic, and dermatological toxicities. …
Bifidobacterium longum BL300 alleviates DSS-induced Colitis by promoting IgA-mediated Gut Microbiota homeostasis
Publication Year: 2025 Source: Food Funct PMID: 40350789 DOI: 10.1039/d5fo00992h
Inflammatory bowel disease (IBD) is a chronic disease that is related to excessive inflammation and an imbalance in the gut microbiota. In this study, the effect of five Bifidobacterium longum subsp. longum strains on alleviating the colitis induced by dextran sulfate sodium (DSS) was investigated. Disease activity index (DAI) scores …
[Research progress in treatment of ulcerative colitis with traditional Chinese medicine]
Publication Year: 2025 Source: Zhongguo Zhong Yao Za Zhi PMID: 40350806
Ulcerative colitis(UC) is a chronic, non-specific inflammatory disease with a complex etiology and a tendency for recurrence. So far, the clinical efficacy of western medicine in treating UC has been poor and is often accompanied by adverse reactions. Therefore, the multi-target, multi-level, synergistic, and heterogeneous characteristics of traditional Chinese medicine(TCM) …
[Effect and mechanism of alkaloids from Portulacae Herba on ulcerative colitis in mice based on TLR4/MyD88/NF-κB signaling pathway]
Publication Year: 2025 Source: Zhongguo Zhong Yao Za Zhi PMID: 40350807
This study investigated the functions and regulatory mechanism of Portulacae Herba and its chemical components on the Toll-like receptor 4(TLR4)/myeloid differentiation primary response 88(MyD88)/nuclear factor kappa B(NF-kappaB) inflammatory signaling pathway in the colon tissue of mice with dextran sodium sulfate(DSS)-induced ulcerative colitis(UC). A total of 35 mice were randomly divided …
[Mechanism of Xiangmei Pills in treating ulcerative colitis based on UHPLC-Q-Orbitrap HRMS and 16S rDNA sequencing of intestinal flora]
Publication Year: 2025 Source: Zhongguo Zhong Yao Za Zhi PMID: 40350808
The efficacy of Xiangmei Pills on rats with ulcerative colitis(UC) was investigated by characterizing the spectrum of the active chemical components of Xiangmei Pills. Rapid identification and classification of the main chemical components were performed,and the therapeutic effects of Xiangmei Pills on the proteins and intestinal flora of UC rats …
[Angelicae Dahuricae Radix polysaccharides treat ulcerative colitis in mice by regulating gut microbiota and metabolism]
Publication Year: 2025 Source: Zhongguo Zhong Yao Za Zhi PMID: 40350809
This study employed 16S r RNA gene high-throughput sequencing and metabolomics to explore the mechanism of Angelicae Dahuricae Radix polysaccharides(RP) in the treatment of ulcerative colitis(UC). A mouse model of UC was induced with 2. 5% dextran sulfate sodium. The therapeutic effects of RP on UC in mice were evaluated …
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