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Exploring the efficacy of Benincasa hispida extract on obesity linked inflammatory bowel disease by integrating computational analysis and experimental validations
Publication Year: 2025 Source: Sci Rep PMID: 40281051 DOI: 10.1038/s41598-025-99256-6
The association of obesity with inflammatory bowel disease (IBD) can be understood by the intricate role of pro- and anti-inflammatory cytokines, especially adipokines, which are secreted by adipose tissue and are responsible for IBD because of their structural similarity with tumor necrosis factor-alpha (TNF-alpha), an important cytokine involved in IBD …
Factors driving persistence to first-line advanced therapies in inflammatory bowel disease: a real-world study from a tertiary referral centre
Publication Year: 2025 Source: Intern Emerg Med PMID: 40281202 DOI: 10.1007/s11739-025-03943-1
Factors driving the persistence of advanced therapies-defined as the duration from therapy initiation to discontinuation-in inflammatory bowel disease (IBD) remain unclear. This study aimed to evaluate the persistence of biologics and oral small molecules in a real-word IBD cohort and to identify influencing factors. Data from IBD patients starting advanced …
Comparative Analysis of Deep Neural Networks for Automated Ulcerative Colitis Severity Assessment
Publication Year: 2025 Source: Bioengineering (Basel) PMID: 40281773
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by continuous inflammation of the colon and rectum. Accurate disease assessment is essential for effective treatment, with endoscopic evaluation, particularly the Mayo Endoscopic Score (MES), serving as a key diagnostic tool. However, MES measurement can be subjective and inconsistent, …
New Therapeutic Challenges in Pediatric Gastroenterology: A Narrative Review
Publication Year: 2025 Source: Healthcare (Basel) PMID: 40281872 DOI: 10.3390/healthcare13080923
Pediatric gastroenterology is entering a pivotal phase marked by significant challenges and emerging opportunities in treating conditions like celiac disease (CeD), eosinophilic esophagitis (EoE), inflammatory bowel disease (IBD), and autoimmune hepatitis (AIH) pose significant clinical hurdles, but new therapeutic avenues are emerging. Advances in precision medicine, particularly proteomics, are reshaping …
IL-1β Induced Intestinal Inflammation Pathogenesis in East Friesian Sheep: Insights from Organoid Modeling
Publication Year: 2025 Source: Animals (Basel) PMID: 40281931 DOI: 10.3390/ani15081097
Establishing an appropriate model of intestinal inflammation in vitro is crucial for studying the pathogenesis of inflammatory bowel disease (IBD). While immortalized cell lines have long been employed to investigate intestinal cell functions and host-pathogen interactions in sheep, they inadequately mimic the physiological characteristics of ovine intestinal inflammation and may …
Mesenchymal Stem Cells in Veterinary Medicine-Still Untapped Potential
Publication Year: 2025 Source: Animals (Basel) PMID: 40282009
Mesenchymal stem cells (MSCs) hold significant therapeutic potential in veterinary medicine due to their regenerative and immunomodulatory properties. This review examines the clinical applications of MSCs across multiple animal species, including equine, canine, feline, and bovine medicine. MSC therapies have demonstrated promising outcomes in treating musculoskeletal disorders, osteoarthritis, inflammatory diseases, …
The Role of IL-23 in the Development of Inflammatory Diseases
Publication Year: 2025 Source: Biology (Basel) PMID: 40282212
Interleukin-23 is crucial in the initiation and progression of certain inflammatory disorders. As a key cytokine, IL-23 is involved in the differentiation and activation of Th17 cells, which play a role in a broad spectrum of inflammatory diseases. This review examines the molecular mechanisms through which IL-23 contributes to the …
Osteopontin in Chronic Inflammatory Diseases: Mechanisms, Biomarker Potential, and Therapeutic Strategies
Publication Year: 2025 Source: Biology (Basel) PMID: 40282293 DOI: 10.3390/biology14040428
Chronic inflammatory diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), atherosclerosis, and inflammatory bowel disease (IBD), pose major global health concerns. These disorders are marked by persistent inflammation, immune system dysfunction, tissue injury, and fibrosis, ultimately leading to severe organ dysfunction and diminished quality of …
MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications-A Review
Publication Year: 2025 Source: Genes (Basel) PMID: 40282401
The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a process essential for the methylation of homocysteine to methionine. Polymorphisms in the MTHFR gene can reduce enzyme activity, disrupting the folate cycle and leading to hyperhomocysteinemia. The two most common polymorphisms associated with this gene are 667C>T …
Protective Effect of Probiotics on Cardiac Damage in Experimental Sepsis Model Induced by Lipopolysaccharide in Rats
Publication Year: 2025 Source: Medicina (Kaunas) PMID: 40282880
Background and Objective: Probiotics have been shown to be effective in controlling various adverse health conditions such as antibiotic-associated diarrhea, inflammatory bowel disease, obesity, and neurological diseases. However, to our knowledge, there is no research on the preventive effect of probiotics on heart damage caused by infections. This study examined …
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