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Editorial: JAK to JAK-Navigating Intraclass JAK Inhibitor Switching in Inflammatory Bowel Disease

Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40631869

No Abstract

Genomic and functional characterization of a Butyricicoccus porcorum strain isolated from human gut microbiota

Publication Year: 2025 Source: mSystems PMID: 40631899

The gut is the most complex microbial ecosystem in the body that greatly influences human immune and metabolic health. However, the functional understanding of gut microbiome is hampered by our limited ability to obtain bacterial cultures for experimental validation, particularly low-abundant species that may carry specific functions but are often …

Global Inflammatory Bowel Disease: Opportunities and Challenges for a New Era

Publication Year: 2025 Source: United European Gastroenterol J PMID: 40632013

Inflammatory Bowel Disease (IBD) has become a global disease. The increasing incidence of inflammatory bowel disease across the world is challenging the traditional view of IBD as a western disease and represents a unique opportunity to gain an understanding of the disease in diverse ethnic groups and in different socio-economical …

Correlation between intestinal ultrasound and fecal calprotectin with endoscopic severity scores for determining the activity in patients with Crohn's disease

Publication Year: 2025 Source: Abdom Radiol (NY) PMID: 40632165

BACKGROUND: Crohn's disease (CD) is a chronic inflammatory bowel disease characterized by relapsing and remitting inflammation of the gastrointestinal tract. Reliable and non-invasive methods to assess disease activity are crucial for guiding treatment and improving patient outcomes. This study investigates how intestinal ultrasound (IUS) parameters and fecal calprotectin (FC) levels …

Targeting macrophage glucose metabolism: Polysaccharide-iron nanozyme-mediated reactive oxygen species/iron homeostasis restoration ameliorates inflammatory bowel disease with anemia comorbidity

Publication Year: 2025 Source: J Colloid Interface Sci PMID: 40633358

Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by intestinal inflammation, with frequent progression to complications including intestinal stenosis, obstruction, and perforation. The sustained inflammatory burden and gastrointestinal bleeding in IBD culminate in systemic iron depletion, predisposing patients to iron deficiency anemia (IDA). Here, we report a rationally …

An International Multicenter Study of Native and Immigrant South Asian Crohn's Disease

Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40633890

BACKGROUND AND AIMS: Crohn's disease (CD) has emerged as a global disease, with the fastest rise in incidence in Asia. The impact of immigration (reflecting early life exposure to one environment, and later life to another) on disease phenotype, behavior, and seropositivity has not been examined previously. METHODS: We phenotyped …

One-Year Comparative Effectiveness and Safety of Upadacitinib Versus Risankizumab for Crohn's Disease

Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40633894

No Abstract

[Recent advance of clinical management of inflammatory bowel disease]

Publication Year: 2025 Source: Nihon Shokakibyo Gakkai Zasshi PMID: 40634073

No Abstract

[Treatment of ulcerative colitis in the era of multiple option:optimization of conventional therapy now once again]

Publication Year: 2025 Source: Nihon Shokakibyo Gakkai Zasshi PMID: 40634075

No Abstract

Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models

Publication Year: 2025 Source: Nat Commun PMID: 40634309

Intestinal fibrosis is a common complication in inflammatory bowel diseases with no specific therapy. Because mineralocorticoid receptor antagonism prevented inflammation and fibrosis in extra-intestinal organs, we aimed to evaluate mineralocorticoid receptor antagonism in intestinal fibrosis. Here we show that pharmacological or smooth cell specific deletion mineralocorticoid receptor antagonism prevented colon …

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