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A framework for clinical care pathway renewal: an example from inflammatory bowel disease
Publication Year: 2025 Source: BMC Med Res Methodol PMID: 40634845
BACKGROUND: Clinical care pathways (CCPs) contribute to standardized, high-quality care and reduce variation in healthcare delivery. However, CCPs must be regularly reviewed and updated to reflect current evidence-based clinical practice guidelines. In the literature, the development and implementation of CCPs is well described, but there is little to guide the …
Vegetative pyodermatitis-pyostomatitis in a patient with Crohn's disease: a clinical case report
Publication Year: 2025 Source: Diagn Pathol PMID: 40634972
INTRODUCTION: Pyodermatitis-pyostomatitis vegetans (PPV) is a rare inflammatory mucocutaneous dermatosis of unknown etiology. It is characterized by the appearance of vesicles, pustules, vegetating plaques, and erythematous lesions, often associated with underlying inflammatory bowel diseases such as Crohn's disease. OBJECTIVE: To report a case of vegetative pyostomatitis in a patient with …
Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
Publication Year: 2025 Source: Korean J Intern Med PMID: 40635486
BACKGROUND/AIMS: This study aimed to evaluate the feasibility and outcomes of mini-probe endoscopic ultrasound (mEUS) followed by submucosal saline injection (SSI-mEUS) for assessing the endoscopic resectability of colorectal subepithelial lesions (SELs). METHODS: From January 2020 to December 2023, the medical records of 391 SELs (364 patients) were retrospectively reviewed and …
Impact of moderate-to-severe ulcerative colitis and Crohn's disease on sexual activity: United States and European patient perspectives from the communicating needs and features of IBD experiences (CONFIDE) survey
Publication Year: 2025 Source: Curr Med Res Opin PMID: 40635574
BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) negatively affect patients' quality-of-life, and their impact on patients' sexual health is rarely addressed. This study assessed the impact of moderate-to-severe UC and CD on sexual activity using United States (US) and European data from the Communicating Needs and Features of IBD …
Development of a technology-enhanced patient-reported outcome evaluation system for inflammatory bowel disease: A multidimensional approach to assessing survival quality
Publication Year: 2025 Source: Technol Health Care PMID: 40635613
BackgroundInflammatory Bowel Disease (IBD) significantly affects patients' long-term health and survival quality. Accurate and technology-driven assessment tools are essential for monitoring disease impact and optimizing individualized treatment strategies.ObjectiveTo develop a standardized and technology-enhanced evaluation system for IBD based on patient-reported outcomes (IBDPRO), enabling a comprehensive and dynamic assessment of patients' …
Role of the Dietitian in the Inflammatory Bowel Disease Multidisciplinary Team
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 40635627
In recent years, nutrition and dietetics have evolved from playing a supporting role in inflammatory bowel disease care to becoming an integral part of the treatment approach. Nutrition and dietary treatments address malnutrition, which is known to be highly prevalent in inflammatory bowel disease patients, reduce active inflammation, provide symptom …
Pathogenesis guided application of nanozymes in the treatment of inflammatory bowel disease
Publication Year: 2025 Source: Mater Today Bio PMID: 40636030
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut that has caused an escalating burden on the global healthcare system in recent years. Researchers have been actively seeking innovative therapeutic strategies to combat this intractable disease. Recent advances in nanozyme technology have opened up new avenues for …
Multi-omics analysis identified macrophages as key contributors to sex-related differences in ulcerative colitis
Publication Year: 2025 Source: Front Immunol PMID: 40636118
BACKGROUND: Ulcerative colitis (UC) has a complex etiology, and whether there are sex-related differences in its molecular mechanisms remains unclear. This study employed multi-omics analysis to explore sex-based differences in UC, aiming to provide support for personalized treatment. METHODS: The GSE36807 and GSE206171 datasets from the GEO database were grouped …
Constructing inflammatory bowel disease diagnostic models based on k-mer and machine learning
Publication Year: 2025 Source: Front Microbiol PMID: 40636504
BACKGROUND: Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is linked to significant alterations in gut microbiota. Conventional diagnostic approaches frequently rely on invasive procedures, contributing to patient discomfort; hence, non-invasive diagnostic models present a valuable clinical alternative. METHODS: Metagenomic and amplicon sequencing data were collected …
Inflammatory Fibroid Polyp or Vanek Tumor as an Uncommon Cause of Adult Intussusception: Diagnostic and Surgical Considerations
Publication Year: 2025 Source: Cureus PMID: 40636665
Inflammatory fibroid polyps (IFPs) or Vanek tumors are rare benign neoplasms of the gastrointestinal tract, with an unknown pathogenesis, that, despite their harmless nature, can lead to small bowel intussusception - a rare cause of intestinal obstruction in adults. In this article, we present the case of a 69-year-old man …
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