Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Can Diet Quality Be Associated with Disease Activity in a Prospective Dutch Inflammatory Bowel Disease Cohort?
Publication Year: 2025 Source: Nutrients PMID: 40284163 DOI: 10.3390/nu17081298
Background/Objectives: Inflammatory bowel disease (IBD) is characterized by a relapsing-remitting disease course, influenced by dietary factors. This study aims to examine diet quality in IBD patients and investigate its association with disease activity. Methods: In total, 477 participants from a prospective IBD cohort study at two Dutch hospitals were approached …
Lactobacillus plantarum 17-1 Ameliorates DSS-Induced Colitis by Modulating the Colonic Microbiota Composition and Metabolome in Mice
Publication Year: 2025 Source: Nutrients PMID: 40284212 DOI: 10.3390/nu17081348
Background/Objectives: Lactobacillus strains are widely used as probiotics in the functional food industry and show potential for treating inflammatory bowel disease (IBD). However, the strain specificity and limited stress resistance of Lactobacillus restricts its therapeutic effectiveness. The aim of this study was to investigate the effects of dietary supplementation with …
An Assessment of the Nutritional Status in Patients with Inflammatory Bowel Disease-A Matched-Pair Case-Control Study
Publication Year: 2025 Source: Nutrients PMID: 40284232 DOI: 10.3390/nu17081369
Methods used in daily clinical practice for the assessment of the nutritional status in patients with inflammatory bowel disease (IBD) are often based on simple indices and may not be sufficient in the case of minor or early changes. The purpose of this study was to analyze the nutritional status …
The Clinical Utility of Precision-Guided Dosing for Adalimumab Therapy Optimization in Inflammatory Bowel Disease: A Clinical Experience Program
Publication Year: 2025 Source: Pharmaceutics PMID: 40284422 DOI: 10.3390/pharmaceutics17040428
Background/Objectives: This study aimed to establish the clinical utility of a therapeutic drug monitoring (TDM)-supported, model-informed precision dosing (MIPD) approach (precision-guided dosing [PGD]) by assessing the impact of pharmacokinetic (clearance [CL]) and clinical laboratory parameters on adalimumab (ADA) dosage adjustments during maintenance therapy for inflammatory bowel disease (IBD). Methods: In …
Role of Gut Microbiota and Metabolomics in Predicting Response to Vedolizumab in Inflammatory Bowel Disease: A Systematic Review
Publication Year: 2025 Source: Pharmaceutics PMID: 40284471 DOI: 10.3390/pharmaceutics17040476
Background: This review explores the impact of gut microbiota profiles in predicting the response to anti-integrin biologic therapy, particularly vedolizumab, in inflammatory bowel disease (IBD) patients. IBD, encompassing Crohn's disease and ulcerative colitis, is a chronic inflammatory condition with a growing prevalence linked to industrialization and lifestyle changes. Disruption in …
Amphiphilic Celecoxib-Polysaccharide Delivery System for Enhanced Colon-Targeted Colitis Therapy
Publication Year: 2025 Source: Pharmaceutics PMID: 40284506 DOI: 10.3390/pharmaceutics17040511
Background: Ulcerative colitis (UC), a subtype of chronic inflammatory bowel disease (IBD), is primarily treated with oral medications to reduce inflammation and alleviate symptoms. Celecoxib (CXB) is an attractive candidate for UC; however, its limited solubility and low bioavailability pose significant challenges to its clinical application. Methods: We reported a …
Optimizing Precision Probiotics for Mitigating Graft-Versus-Host Disease
Publication Year: 2025 Source: Microorganisms PMID: 40284543
Precision probiotics have shown great promise as novel therapies but have not been fully realized. One major obstacle is that different strains of the same gut microbiota species can induce markedly variable phenotypic outcomes. Here, we aimed to optimize and validate in a preclinical model, a six-species precision probiotic therapy …
Impact of Microbiota Diversity on Inflammatory Bowel Disease
Publication Year: 2025 Source: Microorganisms PMID: 40284547 DOI: 10.3390/microorganisms13040710
Inflammatory bowel disease (IBD) is a chronic condition that includes two main types, Crohn's disease (CD) and ulcerative colitis (UC), involving inflammation of the gastrointestinal (GI) tract. The exact cause of IBD is unknown but could be a combination of genetic, environmental, and immune system factors. This study investigated the …
Development and Evaluation of a MinION Full-Length 16S rDNA Sequencing Analysis Pipeline for Rapid Diagnosis of Animal Gastrointestinal Diseases
Publication Year: 2025 Source: Microorganisms PMID: 40284613 DOI: 10.3390/microorganisms13040777
Rapid and accurate detection of the causes of gastrointestinal diseases in farmed and companion animals is crucial for advancing livestock farming and safeguarding public health safety. Diseases caused by pathogenic bacteria infections often result in the overrepresentation of pathogens in the gut microbiota; however, gut microbiota dysbiosis without obvious pathogen …
The Role of Intestinal Fungi in the Pathogenesis and Treatment of Ulcerative Colitis
Publication Year: 2025 Source: Microorganisms PMID: 40284630
Ulcerative colitis (UC) is a chronic inflammatory bowel disease closely associated with dysbiosis of the gut microbiome, encompassing not only bacterial communities but also fungal populations. Despite the growing recognition of the gut microbiome's role in UC pathogenesis, the contribution of intestinal fungi has only recently garnered significant attention. In …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide