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Skin Microbiome Overview: How Physical Activity Influences Bacteria
Publication Year: 2025 Source: Microorganisms PMID: 40284707 DOI: 10.3390/microorganisms13040868
The skin cannot be considered as just a barrier that protects against physical, chemical, and biological damage; it is a complex and dynamic ecosystem that varies across lifespans. Interest in the relationship between physical activity and skin microbiota has grown significantly in recent years. The skin microbiota has a crucial …
The Pathogenic Effects of Moroccan Very Virulent Infectious Bursal Disease Virus on Lymphoid Organs: A Comparative Study in Conventional Broiler and Specific-Pathogen-Free Chickens
Publication Year: 2025 Source: Vet Sci PMID: 40284821 DOI: 10.3390/vetsci12040319
Infectious bursal disease (IBD) is a major immunosuppressive disease affecting young chickens, and causes significant economic losses to the poultry industry. This work represents the first pathogenicity assessment of Moroccan very virulent IBD virus. Molecular characterization and sequence analysis of this isolate previously identified specific substitutions, including seven amino acid …
Lactobacillus paracasei Expressing Porcine Trefoil Factor 3 and Epidermal Growth Factor: A Novel Approach for Superior Mucosal Repair
Publication Year: 2025 Source: Vet Sci PMID: 40284867 DOI: 10.3390/vetsci12040365
Trefoil factor 3 (TFF3) and epidermal growth factor (EGF) exert a promotive effect on the functions of intestinal epithelial cells and offer protection to the intestinal mucosa. Lactobacillus paracasei can ameliorate intestinal mucosal damage. In this study, pPG-pTFF3/27-2, pPG-pEGF/27-2, and pPG-pTE/27-2 were constructed to express porcine TFF3, EGF, and a …
Predictive Factors of Cytomegalovirus Colonic Reactivation in Patients with Active Ulcerative Colitis
Publication Year: 2025 Source: Viruses PMID: 40284998
Cytomegalovirus (CMV)-associated colitis reflects the adverse impact of CMV reactivation on ulcerative colitis (UC). Its diagnosis requires the detection of viral markers in intestinal biopsies sampled during endoscopy, which may constitute invasive and expensive analyses. Moreover, less than 30% of acute flare-ups in steroid refractory UC are associated with CMV …
Transmural Healing Assessed by Combination of Fecal Calprotectin and Intestinal Ultrasonography Is Associated With Reduced Risk of Bowel Damage Progression in Patients With Crohn's Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40285476
BACKGROUND: Fecal calprotectin (Fcal) and intestinal ultrasonography (IUS) could be used as noninvasive tools to monitor mucosal and transmural healing, respectively, in Crohn's disease (CD). We assessed the agreement between Fcal and IUS to detect active CD and investigated their complementary to predict long-term CD outcomes. METHODS: In this prospective …
Fecal Microbiome Reflects Disease State and Prognosis in Inflammatory Bowel Disease in an Adult Population-Based Inception Cohort
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40285477 DOI: 10.1093/ibd/izaf060
INTRODUCTION: We aimed to determine the diagnostic and prognostic potential of baseline microbiome profiling in inflammatory bowel disease (IBD). METHODS: Participants with ulcerative colitis (UC), Crohn's disease (CD), suspected IBD, and non-IBD symptomatic controls were included in the prospective population-based cohort Inflammatory Bowel Disease in South-Eastern Norway III (third iteration) …
Risk Factors for Chronic Kidney Disease in Patients With Crohn's Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40285478 DOI: 10.1093/ibd/izaf039
BACKGROUND: Patients with inflammatory bowel diseases (IBD), including Crohn's disease (CD), are at risk of complications, including kidney disease. It is important to identify IBD patients at higher risk of chronic kidney disease (CKD) to improve prevention and treatment. Here, we investigated the clinical and metabolomic characteristics of CD patients …
Synergistic healing: harnessing snail mucus enriched with carob extract for anti-inflammatory and antioxidant therapy in ulcerative colitis
Publication Year: 2025 Source: J Sci Food Agric PMID: 40285482 DOI: 10.1002/jsfa.14305
BACKGROUND: Inflammatory bowel diseases (IBD), including ulcerative colitis, are characterized by chronic inflammation and oxidative stress, necessitating novel therapeutic approaches. This study explores the therapeutic potential of snail mucus derived from snails fed different concentrations of carob (SSCS) and compares its efficacy to aqueous carob extracts (AECS). Both SSCS and …
Adult-onset inflammatory bowel disease and the risk of venous thromboembolism - a Swedish nationwide cohort study 2007-2021
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40285594 DOI: 10.1080/00365521.2025.2488053
BACKGROUND: Earlier studies, mainly prior to the widespread use of advanced therapy and implementation of guidelines for thromboprophylaxis indicate a doubled risk of venous thromboembolism (VTE) in patients with inflammatory bowel disease (IBD). METHODS: Using Swedish healthcare registers, we identified a population-based cohort of patients with incident IBD 2007-2021. Patients …
Young Adult Patients With Pediatric-Onset Inflammatory Bowel Disease Have a Higher Educational Level and a Higher Employment Rate Than the General Population
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40285695
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