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Primary Gastrointestinal EBV-Associated Classical Hodgkin Lymphoma in Crohn Disease on Anti-TNF-α Therapy: A Rare Association
Publication Year: 2025 Source: JGH Open PMID: 40255389
BACKGROUND: Lymphomas present a significant challenge in the field of gastrointestinal diseases, often being mistaken for other gastrointestinal tumors or inflammatory bowel disease conditions, causing clinical confusion. Early diagnosis plays a pivotal role in effective treatment. This case highlights the importance of recognizing lymphoproliferative disorders as a rare association of …
Collagen Peptides and Saccharomyces boulardiiCNCM I-745 Attenuate Acetic Acid-Induced Colitis in Rats by Modulating Inflammation and Barrier Permeability
Publication Year: 2025 Source: Food Sci Nutr PMID: 40255550
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent episodes of inflammation and tissue damage, with limited treatment options. This study aimed to investigate the effects of collagen peptides and Saccharomyces boulardii on acetic acid (AA)-induced colitis. Thirty-six male Sprague-Dawley rats were randomly divided into the following four …
Mitochondrial Dysfunction and Reduced TCA Cycle Metabolite Levels in Inflammatory Bowel Disease Patients
Publication Year: 2025 Source: J Inflamm Res PMID: 40255656 DOI: 10.2147/JIR.S487349
INTRODUCTION: Inflammatory bowel disease (IBD) mainly includes ulcerative colitis (UC) and Crohn's disease (CD). These diseases are classified as chronic and recurrent inflammatory diseases affecting the digestive tract. An energy deficiency in intestinal cells is believed to be associated with IBD pathology. METHODS: Our study investigated the bioenergetic functionality of …
Development and Validation of Predictive Models for Inflammatory Bowel Disease Diagnosis: A Machine Learning and Nomogram-Based Approach
Publication Year: 2025 Source: J Inflamm Res PMID: 40255659 DOI: 10.2147/JIR.S378069
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic, incurable gastrointestinal disease without a gold standard for diagnosis. This study aimed to develop predictive models for diagnosing IBD, Crohn's disease (CD), and Ulcerative colitis (UC) by combining two approaches: machine learning (ML) and traditional nomogram models. METHODS: Cohorts 1 and 2 …
Harnessing computational immunology to design targeted subunit vaccines for infectious bursal disease in poultry
Publication Year: 2025 Source: Front Bioinform PMID: 40255694 DOI: 10.3389/fbinf.2025.1562997
INTRODUCTION: Infectious bursal disease (IBD), caused by the infectious bursal disease Q8 virus (IBDV), is a highly contagious disease in young chickens, leading to immunosuppression with great economic importance. IBDV, a non-enveloped virus with a bipartite dsRNA genome, infects the bursa of Fabricius, causing severe gastrointestinal disease. Effective vaccines are …
Factors Influencing Decision-Making Preferences Among Patients with Inflammatory Bowel Disease: A Cross-Sectional Study in China
Publication Year: 2025 Source: Patient Prefer Adherence PMID: 40255863
PURPOSE: This study aimed to evaluate the current status and the discrepancies between anticipated and actual involvement in decision-making roles among patients with inflammatory bowel disease, as well as to explore the factors that influenced actual decision-making participation. PATIENTS AND METHODS: From December 2023 to June 2024, a convenience sampling …
Anti-Inflammatory Effects of Huberantha luensis and Ancistrocladus tectorius Extracts Through Inhibition of Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathways
Publication Year: 2025 Source: J Med Food PMID: 40256789
Inflammation is a crucial response to harmful stimuli, but its chronic activation contributes to various diseases, including inflammatory bowel disease, osteoarthritis, and neurological disorders. While nonsteroidal anti-inflammatory drugs are widely used as anti-inflammation drugs, their extended usage often results in severe side effects, emphasizing the need for safer alternatives. Therefore, …
Perianal Crohn's disease: the experience of taking a multiprofessional approach in a tertiary centre setting
Publication Year: 2025 Source: Br J Nurs PMID: 40257093 DOI: 10.12968/bjon.2025.0167
Perianal fistulising Crohn's disease (PFCD) is a debilitating phenotype of Crohn's disease, with a lifetime incidence of 20-30% in people living with the dieases. Symptoms include perianal pain, perianal discharge and faecal incontinence, with repercussions for a patient's physical and mental health, psychosocial wellbeing and productivity. PFCD is challenging to …
Integrated Analysis of Intersecting Neutrophil Signatures in Behçet's Disease and Inflammatory Bowel Disease
Publication Year: 2025 Source: Int J Rheum Dis PMID: 40257285 DOI: 10.1111/1756-185X.70229
INTRODUCTION: Behcet's disease (BD) and inflammatory bowel disease (IBD) are chronic inflammatory diseases characterized by immune system dysregulation. The critical role of neutrophils in these conditions is increasingly recognized. This study aimed to identify a shared set of neutrophils differentially expressed genes (NDEGs) to aid in the differential diagnosis of …
Indole-3-propionic acid protects medium-diversity colitic mice via barrier enhancement preferentially over anti-inflammatory effects
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 40257386 DOI: 10.1152/ajpgi.00256.2024
Metabolites generated from the intestinal microbiota regulate local and distant tissues. One important metabolite generated from l-tryptophan is indole-3-propionic acid (IPA), which has been shown previously to regulate intestinal mucosal homeostasis in specific pathogen-free (SPF)-colonized animals through distinct receptor-mediated events. Interestingly, IPA levels are reduced in patients with inflammatory bowel …
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