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Transient colonization with Blastocystis spp. after transmission via fecal microbiota transplantation
Publication Year: 2025 Source: Eur J Clin Microbiol Infect Dis PMID: 40257672
BACKGROUND: The pathogenicity of Blastocystis spp. is still debated. Guidelines for feces donor screening differ in their advice to screen for Blastocystis spp., but when tested, its presence is a common reason for exclusion. Blastocystis spp. are correlated to increased bacterial alpha-diversity and distinct bacterial groups and therefore its presence …
Mechanism of LncRNA CBR3-AS1 in regulating pyroptosis of intestinal epithelial cells in ulcerative colitis
Publication Year: 2025 Source: J Bioenerg Biomembr PMID: 40257734
Ulcerative colitis (UC) is a common chronic relapsing inflammatory disease that threatens human life. This study aims to explore the mechanism of LncRNA CBR3-AS1 in pyroptosis of intestinal epithelial cells in UC. The levels of CBR3-AS1, KLF2, and SUGT1 in UC cells were detected. After downregulating CBR3-AS1 expression, cell viability …
Rethinking the Use of Biologics in Inflammatory Bowel Disease Patients With Malignancy: Insights From the Treatment of Immune Checkpoint Inhibitor-Induced Colitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40257988
No Abstract
FGF1(ΔHBS) ameliorates DSS-induced ulcerative colitis by reducing neutrophil recruitment through the MAPK pathway
Publication Year: 2025 Source: Br J Pharmacol PMID: 40258390
BACKGROUND AND PURPOSE: Inflammatory bowel diseases (IBDs) constitute chronic inflammatory disease of the gastrointestinal tract, with escalating global prevalence. There is a pressing demand for safe and effective treatments for IBDs. Fibroblast growth factor 1 (FGF1) variant FGF1(DeltaHBS), characterised by reduced mitogenic capacity, has shown promising therapeutic potential in various …
Precisely edited gut microbiota by tungsten-doped Prussian blue nanoparticles for the treatment of inflammatory bowel disease
Publication Year: 2025 Source: J Control Release PMID: 40258476 DOI: 10.1016/j.jconrel.2025.113755
Inflammatory bowel disease (IBD) is characterized by recurring gastrointestinal inflammation, accompanied by a significant rise in global prevalence and disease severity. The overaccumulation of reactive oxygen and nitrogen species (RONS) in the intestinal environment disrupts redox homeostasis and drives pathological overgrowth of Escherichia coli, which are central to IBD pathogenesis. …
SATB2 Loss Is a Sensitive Biomarker for Dysplasia in Inflammatory Bowel Disease
Publication Year: 2025 Source: Lab Invest PMID: 40258492 DOI: 10.1016/j.labinv.2025.104179
Loss of SATB2 expression has emerged as a promising biomarker for dysplasia in inflammatory bowel disease (IBD), but its sensitivity and specificity remain unclear. We retrospectively evaluated immunohistochemical (IHC) staining of SATB2 and p53 in colorectal biopsies from 37 IBD patients (25 men and 12 women; median age: 48 years) …
Gellan gum-based microbeads for Colon-targeted drug delivery: A promising polysaccharide for controlled and site-specific release
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40258547
Targeting drug delivery to the colon presents significant challenges due to unfavorable pH conditions and enzymatic activity in the upper gastrointestinal tract. This obstacle can be overcome with colon-targeted microbeads, which have led to significant advancements in treating colonic diseases such as inflammatory bowel disease and colorectal cancer, as well …
Pediatric Case of Crohn Disease, Immunoglobulin A Nephropathy, and Atopic Dermatitis
Publication Year: 2025 Source: Pediatrics PMID: 40258603
A few studies have reported immunoglobulin A nephropathy (IgAN) complications in pediatric patients with Crohn disease (CD). Additionally, reports of severe atopic dermatitis (AD) complicating CD with IgAN are rare. In this case report, we review the case of a 10-year-old boy with CD later complicated by IgAN and severe …
Comment on "Italian validation of the IBD-disk tool for the assessment of disability in inflammatory bowel diseases"
Publication Year: 2025 Source: Dig Liver Dis PMID: 40258705 DOI: 10.1016/j.dld.2025.04.007
No Abstract
Antioxidant and anti-inflammatory effects of Equisetum arvense L. on acid-induced ulcerative colitis in rats
Publication Year: 2025 Source: Sci Rep PMID: 40258911
Equisetum arvense L. (EAL) has a long history in traditional medicine for its ability to address various digestive and inflammatory conditions. Here, we aimed to evaluate the therapeutic potential of the EAL hydroalcoholic extract (HAEA) compared with the standard medications in a rat model of ulcerative colitis (UC) caused by …
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