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Ethanolic extract of Momordica charantia L. fruits ameloriates TNBS and AA induced colitis in rats: a histological and electron microscopic study
Publication Year: 2025 Source: Biotech Histochem PMID: 40260731 DOI: 10.1080/10520295.2025.2486455
The anti-inflammatory effect of the ethanol extract of Momordica charantia in two different chemically induced inflammatory bowel disease models, which are frequently used in experimental studies, was investigated. For this purpose, IBD models were created with acetic acid (AA) and 2,4,6 trinitrobenzene sulphonic acid (TNBS) in rats and 300 mg/kg …
Human Leukocyte Antigen Haplotypes Predisposing to Celiac Disease in Patients With Endometriosis
Publication Year: 2025 Source: Am J Reprod Immunol PMID: 40260879 DOI: 10.1111/aji.70079
PROBLEM: Immunological abnormalities are well recognized in the pathogenesis of endometriosis and the co-existence of endometriosis with inflammatory bowel disease (IBD) and celiac disease (CD), along with other systemic immune disorders, is clinically relevant. Recent genetic studies revealed some shared genetic traits associated with the co-occurrence of endometriosis with different …
Development and Validation of Crohn's Perianal Fistula Educational Videos and Website for Increasing Patient Knowledge and Engagement
Publication Year: 2025 Source: J Clin Gastroenterol PMID: 40261667
INTRODUCTION: There are few online resources that provide authoritative and comprehensive information on Crohn's perianal fistula (CPF). In this study, we aimed to use a human-centered design thinking approach to develop and validate 2 educational CPF videos and an accompanying website to support patients with CPF. METHODS: We used a …
CNPY2 drives DSS-induced colitis via the macrophage-ROS axis
Publication Year: 2025 Source: Biomed Pharmacother PMID: 40262233 DOI: 10.1016/j.biopha.2025.118078
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, driven by genetic, environmental, and immune system factors. However, its exact mechanisms remain unclear. Here, we demonstrate that CNPY2 plays a critical role in colitis by modulating macrophage activity. Mice with whole-body Cnpy2 knockout (KO) exhibited significantly …
Marine polysaccharides hydrogel with encapsulated mesalazine for the treatment of ulcerative colitis: Integrative effects on inflammation, microbiota, and mucosal repair
Publication Year: 2025 Source: Colloids Surf B Biointerfaces PMID: 40262307
Ulcerative colitis is a chronic non-specific inflammatory disease of the intestine that significantly impacts patient quality of life. This study introduces a OF/CC/SM hydrogel containing oxidized fucoidan (OF), carboxymethyl chitosan (CC), and silk sericin-stabilized mesalazine (SM), designed for rectal administration to target mesalazine delivery specifically to the colon. The OF/CC/SM …
Is the Risk of Developing a Crohn's Disease Increased after Appendectomy? A Systematic Review of the Literature and Meta-Analysis
Publication Year: 2025 Source: Dig Surg PMID: 40262544
INTRODUCTION: The effect of appendectomy on the development of Crohn's disease (CD) is a matter of debate. The aim of this systematic review and meta-analysis was to gather the latest published data to determine whether patients with a history of appendectomy have an increased risk of developing CD or not. …
Psoraleae Fructus affects the livers of normal and ulcerative colitis rats differently by altering bile acid metabolism
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40262682
ETHNOPHARMACOLOGICAL RELEVANCE: Psoraleae Fructus (PF), the dried mature fruit of the leguminous plant Psoralea corylifolia L., is often used as a nutraceutical and to treat ulcerative colitis (UC). However, recently there have been reports of PF-induced liver injury. AIM OF THE STUDY: To investigate the difference and mechanism of hepatotoxicity …
Potential and pitfalls of using identity-by-descent for malaria genomic surveillance
Publication Year: 2025 Source: Trends Parasitol PMID: 40263027 DOI: 10.1016/j.pt.2025.03.012
No Abstract
A smart capsule with a bacteria- and pH-triggered enteric polymer coating for targeted colonic microbiome sampling
Publication Year: 2025 Source: Acta Biomater PMID: 40263059
The gut microbiome is recognized as a critical factor in advancing precision nutrition and medicine for health and in developing dietary recommendations and targeted therapies for gastrointestinal (GI) health and diseases. However, conventional sampling methods, such as fecal analysis and colonoscopy, often fail to capture microbial information from specific regions …
Safety and feasibility of the KONO-S anastomosis technique with biodegradable stent in Crohn's disease: a pilot study
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 40263180
BACKGROUND AND AIMS: The KONO-S (antimesenteric functional end-to-end handsewn) anastomosis has been used for Crohn's disease (CD) recently, with its efficacy in reducing the risk of anastomotic surgical recurrence. However, the anastomotic leakage is also found in CD with this technique. This study aims to evaluate the safety and feasibility …
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