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Acid-resistant chemotactic DNA micromotors for probiotic delivery in inflammatory bowel disease
Publication Year: 2025 Source: Nat Commun PMID: 40263286
Microcapsules composed of synthetic polymeric matrices have attracted considerable attention in delivering oral probiotics. However, existing polymeric microcapsules demonstrate inadequate acid resistance and adaptability, as well as deficiency in the inflamed colon-specificity and uncontrolled release of probiotics therein. Herein, a DNA microcapsule is prepared as a probiotic-transporting micromotor through photo-crosslinking …
Shaping the future of inflammatory bowel disease: a global research agenda for better management and public health response
Publication Year: 2025 Source: Nat Rev Gastroenterol Hepatol PMID: 40263433 DOI: 10.1038/s41575-025-01063-x
Inflammatory bowel disease (IBD) is a growing global health challenge affecting more than 7 million people worldwide. With increasing prevalence across all age groups, including children and adolescents, IBD places substantial strain on health-care systems and society, resulting in high direct medical costs, lost productivity and reduced quality of life. …
Urological Complications of Hirschsprung-Related Crohn's Disease: A Case Report
Publication Year: 2025 Source: Acta Med Indones PMID: 40263677
Hirschsprung disease (HSCR) is a rare congenital intestinal disease characterized by the absence of ganglion cells in the myenteric and submucosal plexuses of the intestine. Individuals with HSCR demonstrate a higher risk for inflammatory bowel disease (IBD), with Chron's disease (CD) commonly observed. Renal and urinary involvement is reported by …
Comprehensive Management of Ulcerative Colitis and its Associated Intra-Extra Intestinal Complications with a Multifunctional Inulin Hydrogel Complex
Publication Year: 2025 Source: Small PMID: 40263912
Excessive accumulation of reactive oxygen species (ROS) and dysbiosis of gut microbiota are pivotal etiological factors in the pathogenesis of ulcerative colitis (UC) and its associated intestinal and extraintestinal manifestations (e.g., intestinal microthrombosis, anxiety, and depression symptoms). This investigation presents a multifunctional inulin complex (PB/NKase@Inulin gel) incorporating Prussian blue nanozymes …
Broad-Spectrum ROS/RNS Scavenging Catalase-Loaded Microreactors for Effective Oral Treatment of Inflammatory Bowel Diseases
Publication Year: 2025 Source: Small PMID: 40263925 DOI: 10.1002/smll.202501341
Inflammatory bowel disease (IBD) such as ulcerative colitis (UC) is an autoimmune disease characterized by persistent inflammation along the gastrointestinal tract with excessive generation of reactive oxygen species (ROS)/reactive nitrogen species (RNS) generation. Here, catalase (CAT)-containing microreactor capsules with long-lasting broad-spectrum ROS/RNS-scavenging capability are developed for the treatment of IBD. …
Chestnut Nonstarch Polysaccharides Enhance Intestinal Barrier Integrity and Modulate Gut Microbiota to Ameliorate DSS-Induced Colitis in Mice
Publication Year: 2025 Source: J Agric Food Chem PMID: 40263970
This study investigated the biological activity of chestnut nonstarch polysaccharide (CNP) after removing starch. CNP was isolated from chestnut, with its monosaccharide composition identified as rhamnose, mannose, fructose, glucuronic acid, ribose, and galacturonic acid. Animal experiments showed that CNP can significantly alleviate the inflammatory response induced by dextran sodium sulfate …
Implementing routine medical and mental health screening in children and adolescents with inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40264344 DOI: 10.1002/jpn3.70039
OBJECTIVES: Living with inflammatory bowel disease (IBD) can have a significant impact on children. Many children with IBD experience symptoms of anxiety or depression. Routine screening for mental health has been recommended. This preregistered study aimed to describe the implementation of patient-reported outcome measures (PROMs) in routine healthcare at an …
Predicting extra-musculoskeletal and peripheral manifestations and their role on biologic treatment in patients with axial spondyloarthritis: TReasure experience
Publication Year: 2025 Source: Arch Rheumatol PMID: 40264484 DOI: 10.46497/ArchRheumatol.2025.10670
OBJECTIVES: This study aimed to examine the frequency and associated factors of extra-musculoskeletal manifestations (EMMs) and peripheral manifestations in an axial spondyloarthritis (axSpA) cohort and their impact on the choice of first biologic treatment. PATIENTS AND METHODS: A total of 1,687 patients with axSpA (978 males, 709 females; mean age: …
Case Report: Macrophage activation syndrome due to multifocal tuberculosis in an immunocompromised patient
Publication Year: 2025 Source: F1000Res PMID: 40265046
No Abstract
Characterising functional redundancy in microbiome communities via relative entropy
Publication Year: 2025 Source: Comput Struct Biotechnol J PMID: 40265160 DOI: 10.1016/j.csbj.2025.03.012
Functional redundancy has been hypothesised to be at the core of the well-evidenced relation between high ecological microbiome diversity and human health. Here, we conceptualise and operationalise functional redundancy on a single-trait level for functionally annotated microbial communities, utilising an information-theoretic approach based on relative entropy that also allows for …
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