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Identification of S100A9 as a target for diagnosis and treatment of Crohn's Disease after Vedolizumab treatment failure
Publication Year: 2025 Source: Immunol Lett PMID: 40280281
The vedolizumab medication is the treatment that precisely targets the gut for Crohn's Disease (CD). It can inhibit the migration of lymphocytes to the intestinal site despite the fact that a significant portion of the population continues to be ineffectively treated. In this study, peripheral blood leukocytes sampled from the …
Advanced therapy screening in inflammatory bowel disease and the impact of clinical nurse specialists: A retrospective analysis of electronic patient records
Publication Year: 2025 Source: Clin Med (Lond) PMID: 40280424 DOI: 10.1016/j.clinme.2025.100317
Advanced therapies (AT), encompassing biologics and small molecules, are a common and important treatment for inflammatory bowel disease (IBD). However, these treatments pose a risk of reactivating latent infections and therefore require pre-treatment infection screening, but compliance with this screening has previously been reported to be poor. Clinical nurse specialists …
Nancy histological index in ulcerative colitis: an interobserver study
Publication Year: 2025 Source: J Clin Pathol PMID: 40280743
The Nancy histological index (NHI) is a measure of disease activity within colorectal biopsies and a predictor of clinical outcome in ulcerative colitis (UC). We measured interobserver agreement (IOA) during NHI scoring of 20 colorectal biopsies in UC by 13 pathologists of varying grade and experience. The level of IOA …
Dietary targeting of TRPM8 rewires macrophage immunometabolism reducing colitis severity
Publication Year: 2025 Source: Cell Death Dis PMID: 40280909 DOI: 10.1038/s41419-025-07553-9
The interplay between diet, host genetics, microbiota, and immune system has a key role in the pathogenesis of inflammatory bowel disease (IBD). Although the causal pathophysiological mechanisms remain unknown, numerous dietary nutrients have been shown to regulate gut mucosal immune function, being effective in influencing innate or adaptive immunity. Here, …
Evaluation of Acute Severe Ulcerative Colitis Predictors for Steroid Therapy Refractoriness
Publication Year: 2025 Source: Dig Dis Sci PMID: 40188169 DOI: 10.1007/s10620-025-08982-4
BACKGROUND: One-third of patients presenting with acute severe ulcerative colitis (ASUC) are steroid-refractory and require either colectomy or rescue therapy. Timely identification of risk factors predictive of steroid non-response in ASUC patients is crucial for initiating early rescue therapy. AIM: To identify factors predicting steroid failure or colectomy in ASUC. …
Colonic epithelial-derived FGF1 drives intestinal stem cell commitment toward goblet cells to suppress inflammatory bowel disease
Publication Year: 2025 Source: Nat Commun PMID: 40188210 DOI: 10.1038/s41467-025-58644-2
Understanding the molecular mechanisms that regulate intestinal epithelial cell (IEC) renewal provides potential targets for inflammatory bowel disease (IBD). Growing evidence has highlighted the importance of epithelial signals in regulating intestinal stem cell (ISC) differentiation. However, it remains unclear which IEC-derived cytokines can precisely regulate ISC commitment toward specific mature …
Neutrophil-to-Lymphocyte Ratio, C-Reactive Protein, and Mean Platelet Volume in Differentiation of Ascites Causes
Publication Year: 2025 Source: Isr Med Assoc J PMID: 40188362
BACKGROUND: Ascites is a product of fluid accumulation within the peritoneal cavity. Underlying etiologies include cirrhosis, congestive heart failure (CHF), nephrotic syndrome, and malignancies. Patients with cirrhotic ascites are at increased risk for infections, especially spontaneous bacterial peritonitis (SBP), which is associated with high rates of morbidity and mortality. Ascites …
Correlation of serum trace elements with clinical features and gut microbiota in patients with Crohn's disease
Publication Year: 2025 Source: J Nutr Biochem PMID: 40188888
Changes of several trace elements have been reported to contribute to the pathogenesis of Crohn's disease (CD), which is associated with gut microbiota imbalance. This study aimed to investigate changes in trace elements in Chinese CD patients, and explore the correlation of trace element status with clinical features and gut …
Study on the ameliorative effect of marine fungus Hansfordia sinuosae extracellular polysaccharide on DSS-induced ulcerative colitis and depression-like behavior
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40188913
Colitis has become a public health problem in recent years due to its high incidence rate. The extracellular polysaccharides produced by microorganisms were reported to possess the ability to alleviate colitis. A mannan (HPA) was isolated from the fermented broth of the marine fungus Hansfordia sinuosae, and its effect on …
Genetic and immunological regulation of gut Microbiota: The Roles of TLRs, CLRs, and key proteins in microbial homeostasis and disease
Publication Year: 2025 Source: Gene PMID: 40189163 DOI: 10.1016/j.gene.2025.149469
The gut microbiota plays a crucial role in human health, influencing metabolism, immune regulation, and neurological function. This review examines the genetic and immunological mechanisms governing microbiota composition, with a focus on key pattern recognition receptors, including Toll-like receptors (TLRs), C-type lectin receptors (CLRs), and signaling proteins such as CARD9 …
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