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Mycobiota and Antifungal Antibodies as Emerging Targets for the Diagnosis and Prognosis of Human Diseases
Publication Year: 2025 Source: J Fungi (Basel) PMID: 40278117
The human body is colonized by diverse microorganisms, with bacteria being the most extensively studied. However, fungi, collectively known as "the mycobiota," are increasingly recognized as integral components of the microbiota, inhabiting nearly all mucosal surfaces. Commensal fungi influence host immunity similarly to bacteria and contribute to other essential functions, …
Non-Adherence Rate to Oral Mesalamine in Ulcerative Colitis Patients: A Systematic Review with Meta-Analysis
Publication Year: 2025 Source: J Pers Med PMID: 40278302 DOI: 10.3390/jpm15040123
Background/Objectives: Ulcerative colitis (UC) is a part of inflammatory bowel disease (IBD) and it is characterized by colonic-mucosal chronic inflammation with intermittent clinical activity. Personalized medicine is becoming more and more a relevant method of approach in this field, and the identification of potential concerns in a single patient may …
Stored Intestinal Biopsies in Inflammatory Bowel Disease Research: A Danish Nationwide Population-Based Register Study
Publication Year: 2025 Source: J Pers Med PMID: 40278308 DOI: 10.3390/jpm15040129
Background. Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a complex inflammatory condition affecting the intestinal tract. Currently, immune-modulating treatments are inadequate for 30-50% of patients and often cause significant side effects, highlighting the urgent need for a personalized medicine approach. Real-world data and archived …
Endoscopic Therapy for Anastomotic Bleeding in Inflammatory Bowel Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40278991 DOI: 10.1007/s10620-025-09029-4
Lower gastrointestinal (GI) anastomotic bleeding in patients with inflammatory bowel disease (IBD) is rare but can be detrimental. Time and effective management is critical to prevent morbidity. Endoscopy has emerged as a minimally invasive and highly effective treatment modality for the management of this complication. However, endoscopic treatment for anastomotic …
Statin Use is Associated with a Less Severe Disease Course In Inflammatory Bowel Disease: A Nationwide Cohort Study 2006-2020
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40279326 DOI: 10.1093/ibd/izaf077
BACKGROUND: Statins reduce the risk of inflammatory bowel disease (IBD), however their effect on IBD disease progression is largely unknown. METHODS: We linked Swedish healthcare registers and performed a nationwide cohort study (2006-2020) of 19 788 adults (>/=18 years) with ulcerative colitis (UC) and 12 582 with Crohn's disease (CD). …
Lower Expression of SARS-CoV-2 Host Cell Entry Genes in the Intestinal Mucosa of IBD Patients With Quiescent or Mildly Active Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40279370 DOI: 10.1093/ibd/izaf079
BACKGROUND: Long-term immunosuppressive therapy typically increases the risk of viral infection, yet during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, inflammatory bowel disease (IBD) patients showed reduced severe coronavirus disease 2019 (COVID-19) susceptibility. This suggests potential overlapping molecular mechanisms between IBD and COVID-19 that warrant investigation. METHODS: From …
The protective role of 3-Indoleglyoxylic acid in Bisphenol S-induced intestinal barrier dysfunction via mitochondrial ROS-Mediated IL-17/CXCL10/TNF-α signaling
Publication Year: 2025 Source: Environ Int PMID: 40279686 DOI: 10.1016/j.envint.2025.109477
Bisphenol S (BPS) has become extensively used in the manufacturing of consumer products. BPS mainly enters the body through food and water, with oral exposure targeting the gastrointestinal tract. However, its safety profile remains contentious and warrants further investigation. In this study, we aimed to assess whether BPS exerts harmful …
A comprehensive review of small molecules, targets, and pathways in ulcerative colitis treatment
Publication Year: 2025 Source: Eur J Med Chem PMID: 40279769 DOI: 10.1016/j.ejmech.2025.117645
Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), poses significant clinical challenges because of its complex pathophysiology, long-term nature, and the limited efficacy of existing treatments. Small-molecule compounds, particularly those that are able to modulate inflammation-related signaling pathways and, in many cases, occur in nature, offer a promising alternative …
Specific MSI2 deletion maintains intestinal barrier integrity by down-regulating ILC3s-derived IL-17 a in mice with colitis
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40279942
BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease with an unknown cause. Previous studies have shown that Group 3 innate lymphoid cells (ILC3s) are crucial for maintaining intestinal mucosal immune homeostasis by producing key cytokines such as IL-22 and IL-17 A. While the RNA-binding protein Musashi-2 (MSI2) is recognized …
Geniposide via enema alleviates colitis by modulating intestinal flora and bile acid metabolites, inhibiting S100A8/S100A9/NF-κB, and promoting TGR5 inhibition of NLRP3 inflammasome
Publication Year: 2025 Source: Phytomedicine PMID: 40279965
BACKGROUND: Geniposide (GE) has potential efficacy in treating ulcerative colitis (UC). However, its reactivity can be affected by rapid degradation after oral administration. Furthermore, increasing oral doses may lead to hepatotoxicity. Thus, We used enema administration, characterized by smaller dose and higher localized concentration in the lesion, to improve the …
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