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Wernicke Encephalopathy Associated with Crohn's Disease
Publication Year: 2025 Source: Acta Med Indones PMID: 40641204
Poorly controlled Crohn's disease is associated with several complications, including malabsorption of vitamins and minerals such as vitamin D, vitamin B12, and vitamin B1 (thiamine). Thiamine, among other vitamins, plays a crucial role in Adenosine Triphosphate formation as well as nerve propagation. Thiamine deficiency initially manifests as wet or dry …
Assessment of PredictSURE IBD Assay in a Multinational Cohort of Patients With Inflammatory Bowel Disease
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40641434
BACKGROUND AND AIMS: PredictSURE IBD is a prognostic blood test that classifies newly diagnosed, treatment-naive Inflammatory Bowel Disease (IBD) patients into 'IBDhi' (high-risk) or 'IBDlo' (low-risk) groups (risk of future aggressive disease). We evaluated this assay in a multinational cohort and explored the effect of concomitant corticosteroids on its discrimination. …
iACT4IBD: a randomised controlled trial of a brief online intervention based on acceptance and commitment therapy to improve wellbeing for adults with inflammatory bowel disease
Publication Year: 2025 Source: Front Digit Health PMID: 40641576
INTRODUCTION: Inflammatory bowel disease (IBD) is associated with high rates of depression and anxiety. Acceptance and Commitment Therapy (ACT) has demonstrated utility across different chronic health conditions, and online ACT interventions may potentially improve access to mental health support. METHODS: This study was a parallel two-arm randomised controlled trial that …
Crohn's & Colitis Foundation's Advanced Practice Provider Preceptorship in Inflammatory Bowel Disease: Addressing the Knowledge Gap
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40641823
BACKGROUND: Inflammatory bowel disease (IBD) management has become increasingly complex and specialized education for advanced practice providers (APPs) is limited. The Crohn's & Colitis Foundation's Advanced Practice Provider Preceptorship was developed to educate IBD APPs to minimize this knowledge gap. METHOD: APP applicants were chosen based on their limited IBD …
Real-World Clinical Effectiveness and Safety of Vedolizumab and Ustekinumab in Biologic-Naïve Patients With Early or Late Crohn's Disease: Results From the EVOLVE Expansion Study
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40641824
BACKGROUND: We evaluated the real-world effectiveness and safety of vedolizumab and ustekinumab as first-line biologics in patients with Crohn's disease (CD), by disease duration. METHODS: EVOLVE Expansion (ClinicalTrials.gov, NCT05056441) was a retrospective medical chart review study in Australia, Belgium, and Switzerland. Biologic-naive patients with CD (>/=18 years old) initiated first-line …
Influence of probiotics and deoxycholate on azathioprine transport in the PAMPA model: insights into pharmacomicrobiomics and interindividual variability in drug response
Publication Year: 2025 Source: Front Pharmacol PMID: 40642001
INTRODUCTION: Interindividual variability in drug response presents a major clinical challenge, necessitating a deeper understanding of contributing factors. While the role of gut microbiota, probiotics and bile acids in modulating drug metabolism, absorption, and bioavailability is increasingly recognized, their precise impact on variability remains an active area of research. Azathioprine, …
Baicalein from Scutellaria baicalensis mitigates oxidative stress through the IIS pathway in a C. elegans model of ulcerative colitis
Publication Year: 2025 Source: Front Pharmacol PMID: 40642017
INTRODUCTION: Ulcerative colitis (UC) is a chronic, nonspecific inflammatory bowel disease with limited therapeutic options. Baicalein, a phenolic flavonoid extracted from Scutellaria baicalensis, has been traditionally used in Chinese medicine for its potent anti-inflammatory, anti-tumor, and antiviral properties. This plant, known as Huang-Qin, is indigenous to East Asia and has …
IL-36/IL-36R signaling promotes CD4(+) T cell-dependent colitis via pro-inflammatory cytokine production
Publication Year: 2025 Source: Front Immunol PMID: 40642091
BACKGROUND: Inflammatory bowel disease (IBD) is a multifactorial, chronic disease that affects approximately 1.5 million people in the United States. Several important factors are implicated in the pathogenesis of IBD, one factor being dysregulation of the immune system. This dysregulation results in the accumulation and stimulation of innate and adaptive …
Clinical efficacy of laparoscopic cholecystectomy combined with percutaneous transhepatic gallbladder drainage in severe acute cholecystitis: an analysis of prognostic risk factors
Publication Year: 2025 Source: Front Surg PMID: 40642456
OBJECTIVE: To analyze the clinical efficacy of laparoscopic cholecystectomy (LC) combined with percutaneous transhepatic gallbladder drainage (PTGBD) in patients with acute critical cholecystitis. METHODS: One hundred patients diagnosed with severe acute cholecystitis were retrospectively selected and categorized into two groups based on the surgical approach: the joint group (n = …
The role of mitochondria-related proteins in inflammation and autoimmune diseases: a causal analysis using Mendelian randomization and colocalization
Publication Year: 2025 Source: Health Inf Sci Syst PMID: 40642590
BACKGROUND: Mitochondria are central to immune regulation, inflammation, and cellular metabolism. Growing evidence suggests that mitochondrial dysfunction contributes to autoimmune disease (AD) pathogenesis by modulating inflammatory pathways and immune cell function. However, the causal relationships between mitochondria-related proteins and ADs remain unclear. METHODS: We conducted a bidirectional two-sample Mendelian randomization …
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