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Half-Pipe Melt Electrowritten Scaffolds Support Engineering of an Immunocompetent Hydrogel-Embedded Intestine-on-a-Chip
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40637282
In vitro models that mimic intestinal mucosal tissue inflammation and assess the sensitizing capacity of food proteins are essential for understanding food allergy mechanisms and improving safety assessments. Current 2D models lack spatial epithelial-immune cell interactions, including dendritic cell (DC) migration and DC-T cell crosstalk. Intestine-on-a-chip (IoC) models are used …
WEO Newsletter: The Impact of Artificial Intelligence on Management of Inflammatory Bowel Disease: An Expert Commentary
Publication Year: 2025 Source: Dig Endosc PMID: 40637816
No Abstract
Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism
Publication Year: 2025 Source: Proc Natl Acad Sci U S A PMID: 40638084
Excessive degradation of the colonic mucin layer by Bacteroides within the human gut microbiota drives inflammatory bowel disease (IBD) in mice. Bacterial carbohydrate sulfatases are key enzymes in gut colonization, and they are elevated in human IBD and correlate with disease severity. Selective inhibitors of carbohydrate sulfatases could function as …
Diversity, distribution, and population structure of Escherichia coli in the lower gastrointestinal tract of humans
Publication Year: 2025 Source: PLoS One PMID: 40638629
Several studies report the diversity, and population structure of Escherichia coli (E. coli) in the human gut, but most used faecal specimens as the source of E. coli for analysis. In the present study, we collected mucosal biopsies from three different locations: the terminal ileum, transverse colon, and rectum from …
Physiologically based pharmacokinetic model of IgG to predict mother-to-fetus transfer of ustekinumab in pregnant patients with inflammatory bowel disease
Publication Year: 2025 Source: J Pharm Sci PMID: 40639462
The placenta serves as a critical interface for maternal-fetal substance exchange, including the active transport of immunoglobulin G (IgG), which is essential for neonatal immune protection. While mechanisms of IgG transfer are well-studied, the impact of therapeutic monoclonal antibodies (mAbs) on placental IgG dynamics during pregnancy remains unclear. This study …
The roles of transient receptor potential vanilloid in autoimmune diseases
Publication Year: 2025 Source: Autoimmun Rev PMID: 40639777
The transient receptor potential vanilloid (TRPV) is a family of tetrameric cation channels, expressed in various tissues and cell types. It includes thermosensitive isoforms (TRPV1-4) and calcium-permeable members (TRPV5-6). In the context of autoimmune diseases, TRPV channels have been firmly established as pivotal regulators that bridge changes in the cellular …
Corrigendum to "Aronia melanocarpa (Michx.) Elliott. attenuates dextran sulfate sodium-induced inflammatory Bowel disease via regulation of inflammation-related signaling pathways and modulation of the gut microbiota" [J. Ethnopharmacol. 292(2022) 115190]
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40640027
No Abstract
COVID-19-associated multiple colonic perforations in a 6-month-old infant: a rare case report
Publication Year: 2025 Source: BMC Pediatr PMID: 40640811
BACKGROUND: While COVID-19 primarily manifests as a respiratory illness, gastrointestinal complications-including severe colitis and perforation-have been reported, particularly in adults. However, such presentations in infants remain exceedingly rare. CASE PRESENTATION: A 6-month-old infant presented with lethargy and poor feeding, initially diagnosed with sepsis. Subsequent testing confirmed COVID-19 positivity. During hospitalization, …
Prevalence of autoimmune diseases is strongly associated with average annual temperatures: systematic review and linear regression analysis
Publication Year: 2025 Source: BMC Rheumatol PMID: 40640896
BACKGROUND: The incidence of autoimmune diseases in cold environments has been a topic of interest due to the observed geographical patterns and potential environmental influences on disease development. We aimed to investigate the prevalence of five main autoimmune diseases in 201 countries according to average annual temperatures. METHODS: Linear regression …
Meta-Analysis: Intravenous Versus Subcutaneous Infliximab in Inflammatory Bowel Disease
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40641122
BACKGROUND: Subcutaneous infliximab may provide multiple benefits over intravenous formulations. However, there is uncertainty about the relative efficacy in inflammatory bowel disease (IBD). AIM: To evaluate the relative efficacy of intravenous versus subcutaneous infliximab in patients with IBD using clinical response, clinical remission, and endoscopic remission outcomes at 30- and …
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