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Novel Enteric Microsphere of Beclomethasone Dipropionate With Colon Delivery and Enhancement of Anti-Inflammatory Effects
Publication Year: 2025 Source: Biopharm Drug Dispos PMID: 40202075
The present study aimed to develop a novel colon-targeting microsphere of beclomethasone dipropionate (cMS/BDP) with enhanced pharmacological effect of BDP in the colon. cMS/BDP was prepared using Eudragit((R)) S-100 by the emulsion solvent diffusion method, and its physicochemical properties were characterized. A pharmacokinetic study was conducted to assess systemic exposure …
Iron deficiency should not be accepted in patients with inflammatory bowel disease - a Scandinavian expert opinion
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40202208 DOI: 10.1080/00365521.2025.2487907
AIM: In this paper, we aim to explain the reason why iron deficiency (ID) is common in patients with inflammatory bowel disease (IBD), how to better apply diagnostic tools to uncover the state of ID as well as how to interpret the results, and not least, how to treat ID …
Clin-STAR Corner: Practice-Changing Advances at the Interface of Gastroenterology & Geriatrics
Publication Year: 2025 Source: J Am Geriatr Soc PMID: 40202331 DOI: 10.1111/jgs.19467
With nearly 60 million Americans aged 65 and older, gastrointestinal (GI) conditions are a leading cause of healthcare utilization in this population. Despite this, older adults remain underrepresented in GI clinical trials and research, limiting evidence-based care. This review highlights three pivotal studies addressing this gap: (1) proton pump inhibitors, …
Association of bile acid diarrhea with symptoms and disease activity in Crohn's disease: post-hoc clinical trial analysis of serum 7a-hydroxy-4cholestern-3-one, C4, in patients with active Crohn's disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 40202488
BACKGROUND AND AIMS: In Crohn's disease (CD), symptomatic and endoscopic assessments often show poor correlation. Bile acid malabsorption is a common comorbidity in these patients and often results in bile acid diarrhea (BAD). This post-hoc clinical trial analysis evaluated BAD presence and its association with symptoms and disease activity in …
Gut Feelings Matter: The Unresolved Questions of Irritable Bowel Syndrome-Like Symptoms in Inflammatory Bowel Disease in Remission
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40202869 DOI: 10.1093/ibd/izaf066
No Abstract
Role of Sishen pill in treating inflammatory bowel diseases through regulating the metabolism of memory Treg cells: An exploration based on the theory of benefiting source of fire and eliminating yin
Publication Year: 2025 Source: Pak J Pharm Sci PMID: 40203447
The incidence of inflammatory bowel diseases (IBDs) is increasing yearly and treatment options remain limited. Sishen Pill (SSP), a Chinese medicine, may aid IBD by impacting energy metabolism and immune response in memory Treg cells, though its exact mechanism remains unclear. This study was designed to investigate the SSP's mechanism …
Exploring the active components and mechanisms of chang-yan-ning granule in inflammation relief: Insights from serum pharmacochemistry and network pharmacology
Publication Year: 2025 Source: Pak J Pharm Sci PMID: 40203448
Chang-Yan-Ning granule (CYNG) is a traditional Chinese patent medicine used to treat ulcerative colitis (UC). In this study, we investigated the effect of CYNG on UC and its mechanism. In this study, the active components in CYNG drug serum were characterized by serum pharmacochemistry and network pharmacology was used to …
A case report of successful treatment of giant internal Iiliac artery aneurysm with endovascular stent graft placement
Publication Year: 2025 Source: Int J Surg Case Rep PMID: 40203626 DOI: 10.1016/j.ijscr.2025.111269
INTRODUCTION: Isolated Internal Iliac artery aneurysms are rare and asymptomatic condition that most of them are diagnosed incidentally. Due to the nonspecific symptoms of IIAAs, their deep anatomical location, and the probability of rupture, they can be fatal. Open surgery is the traditional treatment for IAAs, but open surgery can …
Effect of infectious bursal disease virus infection on the expression of immune checkpoint molecules in SPF chickens
Publication Year: 2025 Source: Vet Immunol Immunopathol PMID: 40203670 DOI: 10.1016/j.vetimm.2025.110933
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by infectious bursal disease virus (IBDV). Immune checkpoint molecules are vital for regulating immune equilibrium, preventing autoimmune responses, and controlling the scale and duration of immune reactions. These molecules are implicated in the immunosuppressive mechanisms initiated …
Implications of hippocampal excitatory amino acid transporter 2 in modulating anxiety and visceral pain in a mouse model of inflammatory bowel disease
Publication Year: 2025 Source: Biochim Biophys Acta Mol Basis Dis PMID: 40203955 DOI: 10.1016/j.bbadis.2025.167832
Inflammatory bowel disease (IBD) is characterized by chronic inflammation and significantly impairs quality of life through anxiety-like behaviors and visceral pain. Early evaluation of the risk of anxiety-like behaviors and visceral pain in IBD patients, along with targeted treatment, may benefit disease management. Visceral pain and anxiety-like behavior are often …
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