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The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs
Publication Year: 2025 Source: Rheumatology (Oxford) PMID: 40199504
No Abstract
Executive Summary: The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs
Publication Year: 2025 Source: Rheumatology (Oxford) PMID: 40199508
No Abstract
Adenosine-generating CD39(+) plasmablasts predispose to successful infliximab therapy in pediatric IBD
Publication Year: 2025 Source: Life Sci Alliance PMID: 40199584 DOI: 10.26508/lsa.202403055
B cells display several immunoregulatory mechanisms including the production of interleukin-10. Ectonucleotidases like CD39 and CD73 influence immune homeostasis by metabolizing eATP and generating immunosuppressive adenosine. The major objective was to examine the expression of those immunoregulatory molecules on B-cell subsets, and, more specifically, to determine their association with an …
Canine intestinal organoids as a platform for studying MHC class II expression in epithelial cells
Publication Year: 2025 Source: BMC Mol Cell Biol PMID: 40200149 DOI: 10.1186/s12860-025-00536-w
BACKGROUNDS: The interplay between intestinal epithelial cells (IECs), the immune system, and the gut microbiome is pivotal for maintaining gastrointestinal homeostasis and mediating responses to ingested antigens. IECs, capable of expressing Major Histocompatibility Complex (MHC) class II molecules, are essential in modulating immune responses, especially CD4 + T cells, in …
Probiotic Lactobacillus-Derived Extracellular Vesicles: Insights Into Disease Prevention and Management
Publication Year: 2025 Source: Mol Nutr Food Res PMID: 40200671
Bacterial extracellular vesicles (BEVs) have emerged as versatile and promising tools for therapeutic interventions across a spectrum of medical applications. Among these, Lactobacillus-derived extracellular vesicles (LDEVs) have garnered significant attention due to their diverse physiological functions and applications in health advancement. These LDEVs modulate host cell signaling pathways through the …
Role of phage therapy in acute gastroenteritis
Publication Year: 2025 Source: J Res Med Sci PMID: 40200968
The gut ecosystem, comprising the gut microbiota and its interactions, plays a crucial role in human health and disease. This complex ecosystem involves a diverse array of microorganisms such as viruses, fungi, and bacteria, collectively known as the gut microbiota. These microorganisms contribute to various functions, including nutrient metabolism and …
Pregnancy in Patients with Inflammatory Bowel Disease: A Narrative Review
Publication Year: 2025 Source: Visc Med PMID: 40201110 DOI: 10.1159/000539158
BACKGROUND: The incidence of inflammatory bowel diseases (IBDs) peaks in the fertile age of both women and men. There is a significant lack of knowledge regarding disease-specific aspects of guiding IBD patients through conception, pregnancy, and delivery in clinical routine. SUMMARY: Patients with IBD often remain voluntarily childless, primarily due …
Perspectives in clinical research on Azathioprine for steroid-dependent ulcerative colitis
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40201324
This study explores the application of Azathioprine in the treatment of ulcerative colitis (UC) and the challenges associated with its long-term use. While short-term studies demonstrate the efficacy of Azathioprine in steroid-dependent UC, long-term data on its risks, including malignancies, infections, and chronic toxicity, remain insufficient. Furthermore, the impact of …
NLRP3 Mediates NOXs-Induced Iron Overload and Inflammation but Not Oxidative Damage in Colons of DSS-Treated Mice
Publication Year: 2025 Source: J Inflamm Res PMID: 40201574 DOI: 10.2147/JIR.S509168
BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with chronic and recurrent characteristics caused by multiple reasons, including iron overload, intestinal inflammation, and barrier dysfunction. Here, we investigated the effects of chemical inhibition of NOXs and NLRP3 activity on colonic iron metabolism and inflammatory reactions in a murine …
Role of noncontrast enhanced abdominal ultrasound in the diagnostic assessment of pediatric inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40201985 DOI: 10.1002/jpn3.70044
OBJECTIVES: Assessment of small bowel involvement when diagnosing inflammatory bowel disease (IBD) delineates clinical subtype and disease extension. The gold standard for small bowel assessment is magnetic resonance enterography (MRE), but MRE is not always feasible for children. Standard, non-contrast enhanced abdominal ultrasound is an acceptable alternative. The study aimed …
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