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The Future of Telehealth-Based Psychological and Mind-Body Interventions for People With Inflammatory Bowel Disease: A Systematic Review
Publication Year: 2025 Source: J Dig Dis PMID: 40210221 DOI: 10.1111/1751-2980.13342
OBJECTIVES: People with inflammatory bowel disease (IBD) suffer from relapsing and remitting symptoms of gastrointestinal upset and are at substantial risk of experiencing comorbid mental distress symptoms. We aimed to conduct a systematic review of the evidence surrounding mental health telehealth interventions for IBD patients. METHODS: We searched EMBASE, MEDLINE, …
Accurate estimation of intraspecific microbial gene content variation in metagenomic data with MIDAS v3 and StrainPGC
Publication Year: 2025 Source: Genome Res PMID: 40210439
Metagenomics has greatly expanded our understanding of the human gut microbiome by revealing a vast diversity of bacterial species within and across individuals. Even within a single species, different strains can have highly divergent gene content, affecting traits such as antibiotic resistance, metabolism, and virulence. Methods that harness metagenomic data …
ETAD: a case series of endoscopic transanastomotic drainage of anastomotic leak by colonoscopy
Publication Year: 2025 Source: Surg Endosc PMID: 40210780
BACKGROUND: Transanal drain placement is the preferred treatment for coloanal and low colorectal anastomotic leaks (AL). Endoscopic placement of double-pigtail stents (DPS) has been described sparingly in the colorectal literature for more proximal AL. Our objective was to investigate the efficacy of endoscopic transanastomotic drain (ETAD) placement in leaks after …
Exploring the genetic components and multi-omics sources of inflammatory bowel disease from the perspective of autoimmune disorders
Publication Year: 2025 Source: Clin Rheumatol PMID: 40210785 DOI: 10.1007/s10067-025-07422-y
BACKGROUND: Inflammatory bowel disease (IBD) and autoimmune disorders result from immune system dysregulation. However, the genetic overlap between them remains unclear. Our study aimed to investigate the genetic mechanisms and structure of IBD from the perspective of autoimmune disorders. METHODS: The genetic correlation (rg) between traits can provide valuable information …
Balance between bile acid conjugation and hydrolysis activity can alter outcomes of gut inflammation
Publication Year: 2025 Source: Nat Commun PMID: 40210868 DOI: 10.1038/s41467-025-58649-x
Conjugated bile acids (BAs) are multi-functional detergents in the gastrointestinal (GI) tract produced by the liver enzyme bile acid-CoA:amino acid N-acyltransferase (BAAT) and by the microbiome from the acyltransferase activity of bile salt hydrolase (BSH). Humans with inflammatory bowel disease (IBD) have an enrichment in both host and microbially conjugated …
Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis
Publication Year: 2025 Source: Mol Med Rep PMID: 40211716
Ulcerative colitis (UC) is a non‑specific inflammatory bowel disease characterized by inflammation of the colonic and rectal mucosa and submucosa and has a globally increasing incidence. A compromised intestinal epithelial barrier function has been established as the primary etiological factor in UC, with necroptosis of intestinal epithelial cells exacerbating barrier …
The Posttraumatic Growth Process Experienced by Chinese Patients Newly Diagnosed With Crohn's Disease: A Longitudinal Descriptive Qualitative Study
Publication Year: 2025 Source: Res Nurs Health PMID: 40211891
Despite negative outcomes, being diagnosed with Crohn's disease, a chronic lifelong condition, may prompt individuals to undergo positive psychological and emotional growth. However, understanding the dynamic process of posttraumatic growth in Chinese patients with Crohn's disease remains unknown. Therefore, this study aims to longitudinally explore the posttraumatic growth process in …
The Impact of Antispasmodic Use on Abdominal Pain and Opioid Use in Inflammatory Bowel Disease: A Population-Based Study
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40211901 DOI: 10.1111/apt.70147
BACKGROUND: Patients with inflammatory bowel disease (IBD) are often prescribed antispasmodics for chronic abdominal pain. Large-scale data regarding efficacy and impact on clinical outcomes are lacking. AIM: To examine the association between antispasmodic use and outcomes of abdominal pain and opioid use before and after propensity matching key demographic and …
Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation
Publication Year: 2025 Source: Gut Microbes PMID: 40212016
Fusobacterium nucleatum (F. nucleatum) has emerged as a potential contributor to ulcerative colitis (UC) pathogenesis, although the specific mechanisms remain incompletely understood. This study demonstrates that F. nucleatum promotes colitis by disrupting intestinal barrier integrity, inducing apoptosis in epithelial cells, and modulating inflammatory pathways. Furthermore, we demonstrate that F. nucleatum …
The current state of pediatric gastroenterology in under-resourced nations
Publication Year: 2025 Source: Ann Med Surg (Lond) PMID: 40212147 DOI: 10.1097/MS9.0000000000003141
BACKGROUND: Pediatric gastroenterology (GI) care in low- and middle-income countries (LMICs) faces substantial challenges due to limited healthcare infrastructure, inadequate resources, and a shortage of specialized healthcare professionals. These challenges lead to delayed diagnoses and treatment, exacerbating the morbidity and mortality associated with pediatric GI diseases, which include both infectious …
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