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Prostate Abscess Associated With Severe Constipation: A Rare Case
Publication Year: 2025 Source: Cureus PMID: 40213739
Severe constipation can cause ischemic bowel disease and other complications in older adults. However, its association with the formation of prostate abscesses has rarely been reported. An 80-year-old male recently presented to our center with syncope, dehydration, and constipation. Contrast-enhanced computed tomography (CT) revealed fecal impaction and a hypodense lesion …
Driving scientific progress and shaping the future of gastroenterology: a new start for our Journal, between innovation, growth and multidisciplinarity
Publication Year: 2025 Source: Minerva Gastroenterol (Torino) PMID: 40213823 DOI: 10.23736/S2724-5985.25.03940-3
No Abstract
Gut microbiota and epigenetic inheritance: implications for the development of IBD
Publication Year: 2025 Source: Gut Microbes PMID: 40213833 DOI: 10.1080/19490976.2025.2490207
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is considered significant global health concerns worldwide. Many studies have demonstrated that environmental and dietary factors influence the gut microbiota, which in turn orchestrates the host immune responses. These interactions are also involved in complex metabolic processes that contribute to …
A correspondence on higher life's essential 8 score is associated with reduced risk of related surgery and all-cause mortality among 3232 individuals with inflammatory bowel disease in a longitudinal cohort study
Publication Year: 2025 Source: Int J Surg PMID: 40214243
No Abstract
Evaluating the role of kynurenine/tryptophan ratio as an indicator of disease activity in Indian patients with inflammatory bowel disease. A case-control study
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40214291 DOI: 10.1080/00365521.2025.2491784
BACKGROUND: Tryptophan (T), an essential amino acid, is primarily metabolized ( approximately 90%) to kynurenine (K) by indoleamine 2,3-dioxygenase 1 (IDO1) mainly in intestinal cells. In inflammatory bowel disease (IBD), there is an increase in IDO1 activity which would increase Kynurenine levels and Kynurenine/Tryptophan (K/T) ratio. We hypothesize that alteration …
Somatostatin and Mannooligosaccharide Modified Selenium Nanoparticles with Dual-Targeting for Ulcerative Colitis Treatment
Publication Year: 2025 Source: ACS Nano PMID: 40214514 DOI: 10.1021/acsnano.5c00355
Inflammatory bowel disease (IBD) is a prevalent condition worldwide, characterized by complex etiologies, limited efficacy of clinical drug treatments, and potential adverse effects. In this study, we designed 269 nm selenium nanoparticles with double-cell targeting for ulcerative colitis treatment. Somatostatin (SST) and mannooligosaccharide (MOS) were employed to functionalize an Eucommia …
Oral Budesonide in Oncology: A Novel Approach to Managing Gastrointestinal Immune-Related Adverse Events
Publication Year: 2025 Source: Curr Treat Options Oncol PMID: 40214925
Budesonide is a potent topical glucocorticosteroid with limited systemic activity owing to its extensive hepatic first-pass metabolism following oral administration. Its efficacy and safety have been well-established in gastroenterology, particularly for inducing and maintaining remission in patients with inflammatory bowel diseases: mild-to-moderate ulcerative colitis, Crohn's disease and microscopic colitis. However, …
Probiotics: a promising future in the treatment of ulcerative colitis?
Publication Year: 2025 Source: Pharmacol Rep PMID: 40214948
Ulcerative colitis is an idiopathic and chronic inflammatory bowel disease, characterized by inflammation of the mucosa of the colon and rectum. Clinical manifestations commonly include abdominal pain, diarrhea (with or without hematochezia), and weight loss. The pathogenesis of ulcerative colitis is multifactorial, involving a combination of genetic predispositions and lifestyle …
Pediatric Autoimmune Pancreatitis: Clinical Findings and Outcomes in Sweden
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40215128 DOI: 10.1002/ueg2.70022
INTRODUCTION: Pediatric autoimmune pancreatitis (AIP) is a rare form of pancreatitis in children with poorly understood pathophysiology. It is a recognized risk factor for chronic pancreatitis in approximately 4% of pediatric cases. This study aims to describe the demographics, clinical characteristics, and outcomes of a large Swedish cohort of pediatric …
Prediction of postoperative recurrence of perianal fistulizing Crohn's disease by fecal calprotectin combined with serum miRNA6086
Publication Year: 2025 Source: J Int Med Res PMID: 40215410
ObjectivesThis study aimed to identify risk factors for postoperative recurrence in patients with perianal fistulizing Crohn's disease and assess the predictive value of fecal calprotectin and serum miRNA6086.MethodsFrom 105 patients with perianal fistulizing Crohn's disease, blood and fecal samples as well as clinical data were collected. Analysis of blood tests, …
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