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Metal ion coordinated tea polyphenol nanocoating for enhanced probiotic therapy in inflammatory bowel disease
Publication Year: 2025 Source: Biomaterials PMID: 40215650 DOI: 10.1016/j.biomaterials.2025.123323
Probiotics encapsulated with metal-phenolic networks (MPNs) present a promising approach for treating inflammatory bowel diseases (IBD). However, current MPN systems predominantly use tannic acid (TA) as the phenolic source, with limited exploration of other polyphenols, and face challenges in long-term stability and biocompatibility. Herein, three alternative tea polyphenols, gallic acid …
NUDT1 aggravates intestinal epithelial barrier injury through oxidative stress in ulcerative colitis
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40215769
BACKGROUND: Nudix hydrolase 1 (NUDT1) plays a crucial role in tumours, where it helps limit cellular damage caused by reactive oxygen species. However, the exact function of NUDT1 in ulcerative colitis (UC) is not well understood. METHODS: NUDT1 expression in the intestinal mucosal tissues of patients with UC was analysed …
Biochanin A mitigates colitis by inhibiting ferroptosis-mediated intestinal barrier dysfunction, oxidative stress, and inflammation via the JAK2/STAT3 signaling pathway
Publication Year: 2025 Source: Phytomedicine PMID: 40215818
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by intestinal barrier dysfunction, oxidative stress, and inflammation. Biochanin A (BCA) is a natural flavonoid found in various plants, known for its anti-inflammatory, antioxidant, and anticancer properties, while its therapeutic role in UC and potential mechanism remains unexplored. PURPOSE: …
L-Arginine and immune modulation: A pharmacological perspective on inflammation and autoimmune disorders
Publication Year: 2025 Source: Eur J Pharmacol PMID: 40216179
L- Arginine (2-Amino-5-guanidinovaleric acid, L-Arg) is a semi-essential amino acid that is mainly produced within the urea cycle. It acts as a key precursor in the synthesis of proteins, urea, creatine, prolamines (including putrescine, spermine, and spermidine), proline, and nitric oxide (NO). WhenL-Arg is metabolized, it produces NO, glutamate, and …
Low Protein Diet Exacerbates Experimental Mouse Models of Colitis through Epithelial Autonomous and Nonautonomous Mechanisms
Publication Year: 2025 Source: J Nutr PMID: 40216295 DOI: 10.1016/j.tjnut.2025.03.031
BACKGROUND: Patients with inflammatory bowel diseases (IBDs) are at risk of protein malnutrition due to increased protein loss or reduced dietary intake. The consequences of protein malnutrition on intestinal epithelial metabolism and disease progression remain poorly understood. OBJECTIVES: Given the critical role of the mechanistic target of rapamycin complex 1 …
A Bacteroides thetaiotaomicron genetic locus encodes activities consistent with mucin O-glycoprotein processing and N-acetylgalactosamine metabolism
Publication Year: 2025 Source: Nat Commun PMID: 40216766
The gut microbiota is a key modulator of human health and the status of major diseases including cancer, diabetes and inflammatory bowel disease. Central to microbiota survival is the ability to metabolise complex dietary and host-derived glycans, including intestinal mucins. The prominent human gut microbe Bacteroides thetaiotaomicron (B. theta) is …
Detecting microbial engraftment after FMT using placebo sequencing and culture enriched metagenomics to sort signals from noise
Publication Year: 2025 Source: Nat Commun PMID: 40216789
Fecal microbiota transplantation (FMT) has shown efficacy for the treatment of ulcerative colitis but with variable response between patients and trials. The mechanisms underlying FMT's therapeutic effects remains poorly understood but is generally assumed to involve engraftment of donor microbiota into the recipient's microbiome. Reports of microbial engraftment following FMT …
Nationwide study on clinical impact of early tumor necrosis factor-α inhibitors following first intestinal resection in biologics-naïve Crohn's disease patients
Publication Year: 2025 Source: Sci Rep PMID: 40216839
In Crohn's disease (CD) patients who have undergone surgery, postoperative recurrence remains a challenge, and there is a lack of investigation into the impact of early anti-tumor necrosis factor (TNF) therapy following surgery on clinical outcomes compared to late use of anti-TNF agents. Utilizing the Health Insurance Review and Assessment …
Predicting the risk of postoperative venous thromboembolism in rhinoplasty patients: a cohort study
Publication Year: 2025 Source: Thromb J PMID: 40217290 DOI: 10.1186/s12959-025-00712-0
BACKGROUND: Venous thromboembolism (VTE) is a rare complication following rhinoplasty surgery, with an occurrence rate generally estimated to be between 0.5% and 1%. In contrast, the occurrence rate of VTE in orthopedic surgeries, particularly in lower limb fracture surgeries, can reach as high as 10% or more. This significant difference …
Unveiling the influence of lipidomes on inflammatory bowel disease: a bidirectional mendelian randomization study
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40217472 DOI: 10.1186/s12876-025-03858-3
BACKGROUND: Plasma lipid homeostasis is pivotal in maintaining intestinal health. Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD) as distinct subtypes, manifests unique metabolic signatures. However, the specific roles of lipids in the pathogenesis and therapeutic targeting of IBD remain inadequately explored. This study aims to …
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