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Infection toxicity assessment of tumor necrosis factor α inhibitors in the treatment of IBD: a real-world study based on the US food and drug administration adverse events reporting system (FAERS)
Publication Year: 2025 Source: Expert Opin Drug Saf PMID: 40156444 DOI: 10.1080/14740338.2025.2486309
BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) inhibitors are widely used to treat inflammatory bowel disease (IBD), but systematic risk assessment of infectious toxicity is still lacking. RESEARCH DESIGN AND METHODS: We used disproportional analysis to calculate infection-related risk signals for four TNF-alpha inhibitors and compared them with infection-related signals for …
Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice
Publication Year: 2025 Source: Dig Dis Sci PMID: 40156662 DOI: 10.1007/s10620-025-09008-9
BACKGROUND: Individuals with inflammatory bowel diseases experience an elevated risk of colorectal cancer driven by chronic inflammation. Current systemic immunosuppressive therapies often cause severe side effects. Live oral biotherapeutics are an emerging treatment modality that directly target the intestines. We have engineered a probiotic Saccharomyces boulardii strain that expresses targeting …
Comparative efficacy of pharmacologic interventions in ulcerative colitis: a network meta analysis
Publication Year: 2025 Source: Inflammopharmacology PMID: 40156676
INTRODUCTION: Ulcerative colitis is chronic inflammatory condition affecting the colon, necessitating remission inducing therapeutic interventions. With the emergence of newer more advanced options, their relative effectiveness remains unclear. This network meta-analysis (NMA) will compare the effectiveness of presently available biologics and small molecules in achieving and maintaining remission among patients …
Small Bowel Perforation in Roux-en-Y Gastric Bypass (RYGB) Secondary to Apolipoprotein A-IV (AApoA-IV) Type Amyloidosis
Publication Year: 2025 Source: Obes Surg PMID: 40156753 DOI: 10.1007/s11695-025-07814-8
BACKGROUND: ApoA-IV amyloidosis is a rare disease that involves the deposition of ApoA-IV protein aggregates in tissues. It commonly presents as cardiac or renal disease, but can, in rare cases, cause small bowel perforation. METHODS: This study describes a case of ApoA-IV type amyloidosis causing small bowel perforation after conversion …
Exploring the mechanism of Sinisan in the treatment of ulcerative colitis with depression based on UPLC-Q-Orbitrap-MS combined with network pharmacology, molecular docking, and experimental validation
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40157401
ETHNOPHARMACOLOGICAL RELEVANCE: SiniSan (SNS), a traditional formula from the Treatise on Typhoid Fever, has been shown in modern clinical practice to effectively treat both ulcerative colitis (UC) and depression, although the underlying mechanisms remain incompletely understood. AIM OF THE STUDY: This study employed UPLC-Q-Orbitrap-MS, network pharmacology, molecular docking, and experimental …
Evaluating the efficacy and safety of emodin, luteolin, and paeonol combination from Dahuang Mudan decoction in ameliorating ulcerative colitis
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40157404
ETHNOPHARMACOLOGICAL RELEVANCE: Dahuang Mudan Decoction is a classic Chinese medicine prescription for treating ulcerative colitis (UC). Previous studies have shown that Dahuang Mudan Decoction has preventive and therapeutic effects on mice with dextran sulfate sodium (DSS) induced colitis. AIM OF THE STUDY: The objective of this research endeavor was to …
Heavy Metals and Inflammatory Bowel Disease
Publication Year: 2025 Source: Gastroenterology PMID: 40157433 DOI: 10.1053/j.gastro.2025.03.018
No Abstract
Function and therapeutic potential of Amuc_1100, an outer membrane protein of Akkermansia muciniphila: A review
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40157674
The gut microbiota-derived protein Amuc_1100, a key outer membrane component of Akkermansia muciniphila, has emerged as a groundbreaking therapeutic agent with unique structural and functional properties. Amuc_1100 exerts multifaceted immune-metabolic effects through novel mechanisms, including modulation of TLR2/4 and JAK/STAT pathways. This review highlights its unique multi-component structure that enables …
Group 1 innate lymphoid cells and inflammatory macrophages exacerbate fibrosis in creeping fat through IFN-γ secretion
Publication Year: 2025 Source: J Gastroenterol PMID: 40158049
BACKGROUND: Creeping fat is a characteristic of Crohn's disease and impacts the disease course. We evaluated creeping fat formation, focusing on innate lymphoid cell-mediated fibrogenesis and its clinical significance. METHODS: Patients with inflammatory lesions in the ileum (the most commonly affected area), who underwent surgical resection at Osaka University or …
Regulatory role of CD177+ neutrophils in BMP signaling pathway and its implications for inflammatory bowel disease, sepsis, and intestinal tumors
Publication Year: 2025 Source: Transl Oncol PMID: 40158420 DOI: 10.1016/j.tranon.2025.102336
OBJECTIVES: Inflammatory bowel disease (IBD), sepsis, and intestinal tumors are major health threats. This study aimed to explore the regulatory role of CD177+ neutrophils in the BMP signaling pathway and its impact on the onset, progression, and treatment of these diseases. METHODS: Gene expression data from the Gene Expression Omnibus …
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