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Effect of invitation to colonoscopy versus faecal immunochemical test screening on colorectal cancer mortality (COLONPREV): a pragmatic, randomised, controlled, non-inferiority trial
Publication Year: 2025 Source: Lancet PMID: 40158525
BACKGROUND: Colonoscopy and the faecal immunochemical test are accepted strategies for colorectal cancer screening in the average-risk population (ie, people aged >/=50 years without personal or family history of colorectal cancer). In this trial, we aimed to compare whether invitation to screening with faecal immunochemical test was non-inferior to colonoscopy …
Artificial Intelligence-Enabled Clinical Trials in Inflammatory Bowel Disease: Automating and Enhancing Disease Assessment and Study Management
Publication Year: 2025 Source: Gastroenterology PMID: 40158739
Artificial intelligence (AI) will fundamentally improve how we perform clinical trials by addressing issues of standardizing disease scoring, improving the sensitivity and precision of activity and phenotype assessments, and automating laborious and time-consuming study functions. Progress in AI image analysis is quickly proving to replicate expert judgment in endoscopy, histology, …
Comments on "Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4(+) T Cells as Predictors for Response to Integrin α4β7-Blocking Therapy in Inflammatory Bowel Disease"
Publication Year: 2025 Source: Gastroenterology PMID: 40158741
No Abstract
Integrated network pharmacology and metabolomics analysis to reveal the potential mechanism of Ershen Wan in ameliorating ulcerative colitis
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40158827
ETHNOPHARMACOLOGICAL RELEVANCE: Ershen Wan (ESW), a classic traditional Chinese medicine (TCM) prescription composed of Psoralea corylifolia Linn. and Myristica fragrans Houtt., has been applied to treat gastrointestinal disorders in clinical practices for thousands of years. However, its potential molecular mechanism in alleviating ulcerative colitis (UC) remains to be elusive. AIM …
Unveiling the multifaceted benefits of Simiao Pill in ulcerative colitis: Integrative analysis of signaling pathways, gut microbiota, and lipid metabolism
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40158828
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disease, is characterized by a prolonged and recurrent course. The classical Traditional Chinese Medicine (TCM) formula Simiao Pill (SMP) has demonstrated unique and widespread therapeutic effects on diarrhea and other intestinal inflammation. However, its material basis and potential mechanisms of …
Bronchiectasis in Patients With Inflammatory Bowel Diseases: Prevalence, Predictors, and Clinical Characteristics
Publication Year: 2025 Source: Chest PMID: 40158846 DOI: 10.1016/j.chest.2025.03.014
BACKGROUND: Inflammatory bowel diseases (IBDs) are known to be associated with bronchiectasis (BE). However, data on patients with inflammatory bowel disease-related bronchiectasis (IBD-BE) are limited. RESEARCH QUESTION: What are the prevalence, risk factors, and clinical characteristics of IBD-BE? STUDY DESIGN AND METHODS: This was a single-center retrospective study including patients …
Causal Associations between Particulate Matter 2.5 (PM (2.5)), PM (2.5) Absorbance, and Inflammatory Bowel Disease Risk: Evidence from a Two-Sample Mendelian Randomization Study
Publication Year: 2025 Source: Biomed Environ Sci PMID: 40159170 DOI: 10.3967/bes2024.142
OBJECTIVE: Several epidemiological observational studies have related particulate matter (PM) exposure to Inflammatory bowel disease (IBD), but many confounding factors make it difficult to draw causal links from observational studies. The objective of this study was to explore the causal association between PM (2.5) exposure, its absorbance, and IBD. METHODS: …
Iron Deficiency in Adults: A Review
Publication Year: 2025 Source: JAMA PMID: 40159291 DOI: 10.1001/jama.2025.0452
No Abstract
Obesity and Clinical Characteristics of Inflammatory Bowel Disease
Publication Year: 2025 Source: Obes Facts PMID: 40159346 DOI: 10.1159/000545436
INTRODUCTION: The frequency of obesity and possible correlations with characteristics and outcome of inflammatory bowel disease (IBD) are undefined. Primary aim was to assess the body mass index (BMI) distribution in IBD patients in follow-up. Secondary aim was to compare clinical characteristics and course of IBD in normal weight versus …
Insights Into Disability and Disability Progression in People With Multiple Sclerosis Using Large-Scale Healthcare Data
Publication Year: 2025 Source: Eur J Neurol PMID: 40159595
BACKGROUND: Identifying predictors for disability progression is crucial for managing multiple sclerosis (MS). This study aims to explore levels of disability and informative factors for disability progression in people with MS (PwMS) using healthcare data without detailed clinical information. METHODS: We conducted a case-control/cohort study on data from Bavaria's largest …
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