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Genetic and environmental factors influencing Crohn's disease
Publication Year: 2025 Source: World J Gastrointest Surg PMID: 40162410
This editorial discusses Pellegrino and Gravina's essay. Crohn's disease (CD) is a complex and multifactorial disease that is influenced by a combination of genetic and environmental factors. While genetic factors play a key role in the development of the disease, environmental factors also play a significant role in influencing the …
Artificial Intelligence for Classification of Endoscopic Severity of Inflammatory Bowel Disease: A Systematic Review and Critical Appraisal
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40163659 DOI: 10.1093/ibd/izaf050
BACKGROUND: Endoscopic scoring indices for ulcerative colitis and Crohn's disease are subject to inter-endoscopist variability. There is increasing interest in the development of deep learning models to standardize endoscopic assessment of intestinal diseases. Here, we summarize and critically appraise the literature on artificial intelligence-assisted endoscopic characterization of inflammatory bowel disease …
The Impact of Endoscopic Healing on Disease-Related Outcomes in Patients With Ulcerative Proctitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40163674 DOI: 10.1093/ibd/izaf044
BACKGROUND AND AIMS: Ulcerative proctitis (UP) is a limited form of ulcerative colitis. While achieving endoscopic healing (EH) in ulcerative colitis improves long-term outcomes, the benefit of EH in UP is uncertain. This study aimed to assess the impact of EH on outcomes in UP. METHODS: This single-center retrospective study …
Ability of ChatGPT to Replace Doctors in Patient Education: Cross-Sectional Comparative Analysis of Inflammatory Bowel Disease
Publication Year: 2025 Source: J Med Internet Res PMID: 40163853 DOI: 10.2196/62857
BACKGROUND: Although large language models (LLMs) such as ChatGPT show promise for providing specialized information, their quality requires further evaluation. This is especially true considering that these models are trained on internet text and the quality of health-related information available online varies widely. OBJECTIVE: The aim of this study was …
Chemical structure and anti-inflammatory effects on intestinal epithelial cells of a novel mannogalactan purified from Typhonium giganteum Engl
Publication Year: 2025 Source: Carbohydr Res PMID: 40163911 DOI: 10.1016/j.carres.2025.109467
Inflammatory bowel disease (IBD) remains a pressing global health challenge due to its complex pathogenesis and limited treatment efficacy. Mannogalactans, abundant in certain algae and edible fungi, are recognized for their diverse biological functions, particularly their potent anti-inflammatory effects. Motivated by these findings, we hypothesized that Typhonium giganteum Engl. may …
[Update on diagnostics and therapies in inflammatory bowel diseases]
Publication Year: 2025 Source: Dtsch Med Wochenschr PMID: 40164092
No Abstract
[Advanced therapies: Un update on medical treamtent options in Crohn`s disease]
Publication Year: 2025 Source: Dtsch Med Wochenschr PMID: 40164094 DOI: 10.1055/a-2368-7173
No Abstract
[Update on drug therapy for ulcerative colitis]
Publication Year: 2025 Source: Dtsch Med Wochenschr PMID: 40164095 DOI: 10.1055/a-2368-7090
Ulcerative colitis (UC) is classified as a chronic inflammatory bowel disease (IBD) and can present in various degrees of severity. In addition to mild courses of the disease, such as uncomplicated proctitis, which can often be successfully treated with topical 5-ASA formulations, complicated courses can be observed, which can sometimes …
[Endoscopy in Inflammatory Bowel Diseases: From Proven to New]
Publication Year: 2025 Source: Dtsch Med Wochenschr PMID: 40164096
Inflammatory bowel diseases with the 2 main forms - ulcerative colitis and Crohn's disease - are chronic relapsing diseases of the gastrointestinal tract in which dysregulation of the intestinal immune system against commensal components of the microbiome leads to perpetuated intestinal inflammation based on a genetic predisposition. While in the …
[New and current therapeutic goals of chronic inflammatory bowel disease]
Publication Year: 2025 Source: Dtsch Med Wochenschr PMID: 40164097 DOI: 10.1055/a-2335-5901
Chronic inflammatory bowel diseases (IBD), such as Crohn's disease (MC) and ulcerative colitis (CU), are serious immune-mediated diseases that affect the gastrointestinal tract and represent a considerable burden for patients. In recent decades, the treatment of IBD has shifted from symptomatic control to more precise, long-term goals. Advances in IBD …
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