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Dunhuang Dabupi Decoction and its active components alleviate ulcerative colitis by activating glutathione metabolism and inhibiting JAK-STAT pathway in Drosophila and mice
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40164365
ETHNOPHARMACOLOGICAL RELEVANCE: Dabupi Decoction (DBPD) originates from the ancient Dunhuang medical literature "Fu Xing Jue Visceral to Drug law legend" for more than 1000 years, which has been extensively employed to treat various diseases related to the spleen and stomach. However, limited studies focus on the mechanism of DBPD against …
Treat-to-target of endoscopic remission in patients with inflammatory bowel disease in symptomatic remission on advanced therapies (QUOTIENT): rationale, design and protocol for an open-label, multicentre, pragmatic, randomised controlled trial
Publication Year: 2025 Source: BMJ Open Gastroenterol PMID: 40164445 DOI: 10.1136/bmjgast-2024-001615
INTRODUCTION: Targeted immunomodulators (eg, advanced therapies) effectively achieve symptomatic remission in patients with inflammatory bowel disease (IBD). However, ~25%-50% of patients with IBD achieving symptomatic remission with an advanced therapy may have continued endoscopically/radiologically active bowel inflammation, and it is uncertain whether changing alternative advanced therapies in asymptomatic patients with …
Publisher Correction: Fibrosis: cross-organ biology and pathways to development of innovative drugs
Publication Year: 2025 Source: Nat Rev Drug Discov PMID: 40164812
No Abstract
C1Q(+) TPP1(+) macrophages promote colon cancer progression through SETD8-driven p53 methylation
Publication Year: 2025 Source: Mol Cancer PMID: 40165182 DOI: 10.1186/s12943-025-02293-y
BACKGROUND: In many tumors, the tumor suppressor TP53 is not mutated, but functionally inactivated. However, mechanisms underlying p53 functional inactivation remain poorly understood. SETD8 is the sole enzyme known to mono-methylate p53 on lysine 382 (p53(K382me1)), resulting in the inhibition of its pro-apoptotic and growth-arresting functions. METHODS: We analyzed SETD8 …
A systematic review and network meta-analysis of the association between periodontitis and inflammatory bowel diseases
Publication Year: 2025 Source: BMC Oral Health PMID: 40165211 DOI: 10.1186/s12903-025-05830-9
OBJECTIVES: Several earlier studies have shown that IBD (including its two subtypes, ulcerative colitis (UC) and Crohn's disease (CD)) increases the risk of periodontal disease. This study aimed to evaluate the relevance among periodontitis and IBD subcategories. METHODS: This study was conducted based on PRISMA guidelines. The Web of Science, …
Panax notoginseng Saponins Alleviate Inflammatory Bowel Disease via Alteration of Gut Microbiota-Bile Acid Metabolism
Publication Year: 2025 Source: Am J Chin Med PMID: 40165428 DOI: 10.1142/S0192415X25500223
Bile acid metabolism mediated by gut microbiota is significantly related to immunity regulation that plays an important role in the development and treatment of inflammatory bowel disease (IBD). Our previous study has demonstrated that Panax notoginseng saponins (PNS) alleviate colitis due to the regulation of T helper 17/Regulatory T cells …
Prevalence and trend of anemia in children with inflammatory bowel disease: A national register-based cohort study
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40165528 DOI: 10.1002/jpn3.70029
OBJECTIVES: We determined the prevalence of anemia and its characteristics in children with newly diagnosed inflammatory bowel disease (IBD) and investigated its trend during follow-up. METHODS: An observational, multicenter cohort study of IBD children with anemia at the diagnosis enrolled in the Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition …
Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease
Publication Year: 2025 Source: Physiol Rep PMID: 40165585 DOI: 10.14814/phy2.70292
The field of extracellular vesicles (EVs) is advancing rapidly, and this review aims to synthesize the latest research connected to EVs and the gastrointestinal tract. We will address new and emerging roles for EVs derived from internal sources such as the pancreas and immune system and how these miniature messengers …
Letter: Exclusive Enteral Nutrition in Ulcerative Colitis-The Path Ahead Needs Careful Consideration. Authors' Reply
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40165623
No Abstract
Hermansky-Pudlak Syndrome Complicated by Crohn's Disease and Hidradenitis Suppurativa: A Case of Multisystem Immune Dysregulation
Publication Year: 2025 Source: ACG Case Rep J PMID: 40165941
Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder marked by defects in lysosomal function that can manifest with a granulomatous enterocolitis resembling Crohn's disease (CD). We present a 16-year-old adolescent boy with HPS-associated CD and hidradenitis suppurativa (HS), representing one of a few cases of HPS with concurrent CD …
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